 Home > Encyclopedia > Lapatinib ditosylate

Lapatinib ditosylate

Lapatinib ditosylate structure

CAS No:
388082-77-7
Formula:
C29H26ClFN4O4S.2C7H8O3S
Chemical Name:
Lapatinib ditosylate
Synonyms:
4-Quinazolinamine,N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-,4-methylbenzenesulfonate (1:2);4-Quinazolinamine,N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-,bis(4-methylbenzenesulfonate);Lapatinib ditosylate;GW 572016F;Tykerb
Categories:
Active Pharmaceutical Ingredients > Antineoplastic Agents

Description

Yellow Solid

A quinazoline derivative that inhibits EPIDERMAL GROWTH FACTOR RECEPTOR and HER2 (RECEPTOR, ERBB-2) tyrosine kinases. It is used for the treatment of advanced or metastatic breast cancer, where tumors overexpress HER2.

Lapatinib ditosylate Basic Attributes

Molecular Weight：

925.46

Exact Mass：

924.174

EC Number：

1312995-182-4

NSC Number：

727989

ATC Code：

L01XE07

HScode：

29420000

Characteristics

PSA：

240

XLogP3：

12.32880

Appearance：

Yellow solid

Melting Point：

240-2420C

Boiling Point：

750.7°C at 760 mmHg

Flash Point：

407.8ºC

Storage Conditions：

-20°C Freezer, Under Inert Atmosphere

Safety Information

safety instructions：

24/25

Precautionary statement(s)：

P201, P202, P260, P263, P264, P270, P273, P281, P308+P313, P314, P405, P501

Hazard Statements：

H360

Drug Information

Drug Indication：

Tyverb is indicated for the treatment of patients with breast cancer, whose tumours overexpress HER2 (ErbB2):in combination with capecitabine for patients with advanced or metastatic disease with progression following prior therapy, which must have included anthracyclines and taxanes and therapy with trastuzumab in the metastatic setting;in combination with trastuzumab for patients with hormone-receptor-negative metastatic disease that has progressed on prior trastuzumab therapy or therapies in combination with chemotherapy;in combination with an aromatase inhibitor for post-menopausal women with hormone-receptor-positive metastatic disease, not currently intended for chemotherapy. The patients in the registration study had not previously been treated with trastuzumab or an aromatase inhibitor. No data are available on the efficacy of this combination relative to trastuzumab in combination with an aromatase inhibitor in this patient population.|Drug: Lapatinibditosylate

MeSH：

Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)|Agents that inhibit PROTEIN KINASES. (See all compounds classified as Protein Kinase Inhibitors.)

MeSH Entry Terms：

GW 282974X

Lapatinib ditosylate Use and Manufacturing

Uses

Lapatinib Ditosylate (GW572016, GW2016, Tykerb, Tyverb) is a potent EGFR and ErbB2 inhibitor with IC50 of 10.8 and 9.2 nM, respectively.

Use Classification：

Human drugs -> Tyverb -> EMA Drug Category|Protein kinase inhibitors -> Human pharmacotherapeutic group|Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:753.3
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:12
Rotatable Bond Count:12
Exact Mass:752.1541476
Monoisotopic Mass:752.1541476
Topological Polar Surface Area:178
Heavy Atom Count:51
Complexity:1100
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Recommended Suppliers of Lapatinib ditosylate

Greenbo Biochem Contact Supplier

CN
5 YRS

Business licensed Certified factory

Manufactory Supplier of Active Pharm Ingredients,Chemical Catalyst,Pharmaceutical Intermediates,Flavors and Fragrances,Agrochemicals,Chemical Pesticides,Organic Intermediates,OLED Intermediates

Lapatinib ditosylate 99% white powder GB0311 Greenbo

CAS No.: 388082-77-7

Grade: Pharmaceutical Grade

Content: 99%

Inquiry
NATURE INDUSTRIAL LIMITED Contact Supplier

HK
2 YRS

Business licensed

Trader Supplier of Weight Loss Peptide,Reta,Tirz,Sema,5 Amino 1mq,Cosmetic raw material,API,SLU-PP-332,Orforglipron,Pharmaceutical intermediates,Aniracetam,Paraxanthine,AF710B,Clascoterone,TAK-653,PRL-8-53

Pharmaceutical Raw Material Lapatinib Ditosylate Powder Lapatinib Ditosylate

CAS No.: 388082-77-7

Grade: Pharmaceutical Grade

Content: 99%

Inquiry
Creative Enzymes Contact Supplier

US
6 YRS

Business licensed Certified factory

Manufactory Supplier of Coenzymes,Inhibito,Enzymes,Zymogens,Substrates

Lapatinib Ditosylate(Tykerb)

CAS No.: 388082-77-7

Content: 99%

Inquiry
Shandong Boyuan Pharmaceutical Co., Ltd. Contact Supplier

CN
5 YRS

Business licensed Certified factory

Manufactory Supplier of Terbinafine hydrochloride,Carboplatin,Pramipexole dihydrochloride Monohydrate,Cisatracurium Besylate,Rivaroxaban,Lenvatinib,Febuxostat,Pemetrexed,Capecitabine,Oxaliplatin,Cisplatin,Ezetimibe,Mitiglinide Calcium,Lapatinib,Dasatinib,Osimertinib,Olaparib,Palbociclib,Lenalidomide,Bortezomib,Enzalutamide,Pemetrexed disodium heptahydrate,Ropivacaine HCL,Atracurium Besylate,Racecadotril,Apremilast,Vonoprazan Fumarate,Crisaborole,Rimegepant

Lapatinib ditosylate

CAS No.: 388082-77-7

Grade: Pharmaceutical Grade

Content: 99%

Inquiry