Dorzolamide hydrochloride
-
Dorzolamide hydrochloride
structure -
-
CAS No:
130693-82-2
-
Formula:
C10H16N2O4S3.ClH
-
Chemical Name:
Dorzolamide hydrochloride
-
Synonyms:
4H-Thieno[2,3-b]thiopyran-2-sulfonamide,4-(ethylamino)-5,6-dihydro-6-methyl-,7,7-dioxide,hydrochloride (1:1),(4S,6S)-;4H-Thieno[2,3-b]thiopyran-2-sulfonamide,4-(ethylamino)-5,6-dihydro-6-methyl-,7,7-dioxide,monohydrochloride,(4S-trans)-;4H-Thieno[2,3-b]thiopyran-2-sulfonamide,4-(ethylamino)-5,6-dihydro-6-methyl-,7,7-dioxide,monohydrochloride,(4S,6S)-;L 671152;MK 507;Trusopt;Dorzolamide hydrochloride;(S,S)-(-)-5,6-Dihydro-4-ethylamino-6-methyl-4H-thieno[2,3-b]thiopyran-2-sulfonamide-7,7-dioxide monohydrochloride;Biosopt;(4S,6S)-4-(Ethylamino)-5,6-dihydro-6-methyl-4H-thieno-[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide hydrochloride;206984-09-0
- Categories:
-
CAS No:
Description
Dorzolamide Hcl(L671152 Hcl; MK507 Hcl) is an anti-glaucoma agent, which is a carbonic anhydrase inhibitor.Target: carbonic anhydrase (CA)Dorzolamide hydrochloride is a carbonic anhydrase inhibitor. It is an anti-glaucoma agent, and acts by decreasing the production of aqueous humour [1]. Glaucoma was induced in the right eye of adult Wistar rats by episcleral venous occlusion. One experimental group was administered dorzolamide hydrochloride 2%-timolol 0.5% combination eye drops, while
Characteristics
151
4.66680
1.53 g/cm3
283-285 °C
575.8°C at 760 mmHg
302ºC
Refrigerator
D24 -8.34° (c = 1 in methanol)
Safety Information
NONH for all modes of transport
XJ9095163
P260, P264, P270, P301+P312, P314, P330, P501
H302
Dorzolamide hydrochloride Use and Manufacturing
(4S-trans)-4-(N-ethylamino)-5, 6-dihydro-6-methyl-4H-thien-(2, 3-b)-thiopyran-2-sulfonamide-7, 7-dioxide Hydrochloride [0145] [CHEMMOL-00030] [0146] 0.55 g (0.0017 mol) of (4S-trans)-4-(N-ethylamino)-5, 6-dihydro-6-methyl-4H-thien-(2, 3-b)-thiopyran-2-sulfonamide-7, 7-dioxide are dissolved in 25 ml of ethyl acetate, and the pH is set to 1 with hydrochloric acid. The crude product is concentrated to dryness obtaining 0.62 g (95percent) of the title product with a rotary power of [α]D=-8.3° (c=1, methanol).Example 7 Preparation of 5, 6-Dihydro-4H-4-ethylamino-6-methylthieno[2, 3-b]thiopyran-2- sulfonamide-7, 7-dioxide hydrochloride(a) Dorzolamide di-p-toluyl-L-tartrate salt as prepared in example 6 (44.26 gms, 0.085 moles) was taken in ethyl acetate (557.0 ml), basified with saturated sodium bicarbonate solution. Reaction mass was stirred for 15 minutes at 25°C to 3O
An inhibitor of carbonic anhydrase.
Recommended Suppliers of Dorzolamide hydrochloride
-
![China]()
CN
5 YRS
Business licensed Certified factoryManufactory Supplier of Dichloromethane,Linocaine hydrochloride -
![China]()
CN
5 YRS
Business licensedDistributor Supplier of DIMETHYL SULFOXIDE,NMP,MMTInquiryUnit Price: $1100-1300 /KG FOBCAS No.: 130693-82-2Content: 99% -
![India]()
IN
1 YR
Business licensed Certified factoryManufactory Supplier of atorvastatin,dorzolamide,montelukast -
![China]()
CN
4 YRS
Business licensedTrader Supplier of Semaglutide,Tirzepatide,API,EnzymeInquiryCAS No.: 130693-82-2Grade: Pharmaceutical GradeContent: 99.5%
Latest News on Dorzolamide hydrochloride
- BMS Over $900 Million to Help Develop Potential 'Best-in-class' SHP2 Inhibitors
- AbbVie's blockbuster product for atopic dermatitis, Upadacitinib, has been approved for marketing in the EU and Japan
- Designing peptide inhibitors for possible COVID-19 treatments
- Chinese scientists discover the inhibitors of SARS-CoV-2
Learn More Other Chemicals
-
4H-1-Benzopyran-4-one, 2-[4-[3-(dibutylamino)propoxy]-3,5-dimethylbenzoyl]-, hydrochloride (1:1)
67652-33-9
-
Cyclopropanecarboxylic acid, 1-amino-2-ethenyl-, ethyl ester, hydrochloride (9CI)
681807-60-3
-
CYCLOPENTYL-(3,4,5-TRIMETHOXY-BENZYL)-AMINE HYDROCHLORIDE
1052525-88-8
-
2-Cyclopropylbenzenemethanamine hydrochloride Formula
118184-64-8
-
Des[4-(2-cycloproylMethoxy)] Betaxolol Hydrochloride Formula
464877-45-0
-
Ethanamine, 2-(decylthio)-, hydrochloride (1:1) Formula
36362-09-1
-
4,7-Dichloro-2-propylquinoline hydrochloride Structure
1204812-22-5
-
6,7-Dichloro-4-hydrazino-2-methylquinoline hydrochloride Structure
1170377-12-4
-
What is 2,8-Diazaspiro[4.5]decan-1-one, 2-[(4-bromophenyl)methyl]-, hydrochloride (1:1)
832710-56-2
-
What is 6,7-Dichloro-4-hydrazinoquinoline hydrochloride
1171843-02-9