2-Bromo-7-iodo-9H-fluorene

4a (2.500 g, 10.2 mmol), IA. Synthesis of Intermediate 20 [0204] A 3-neck flask was charged with 2-bromofluorene (100 g) and acetic acid (2100 g). The contents were heated to 40-45° C. and agitated for approximately 30 minutes to obtain a clear solution. After adjusting the internal temperature to 20-30° C., 20percent (v/v) aq. HA. Synthesis of Intermediate 20 [0240] A 3-neck flask was charged with 2-bromofluorene (100 g) and acetic acid (2100 g). The contents were heated to 40-45° C. and agitated for approximately 30 minutes to obtain a clear solution. After adjusting the internal temperature to 20-30° C., 20percent (v/v) aq. HCompound D (40g, 0.16mop, iodine (16.9g, 0.066mop, iodic acid (6.89g, 0.039moq were added to the two-neck flask. distilled water (30mp, acetic acid (600mL), and sulfuric acid (14.4mL) were added and the mixture was slimed at 85C for 4 hoots. Upon completion of the reaction, the mixture was completely cooled to room temperature and washed with acetic acid and distilled water. Pure Compound E (49g, 82percent) was obtained by filtration.EXAMPLE 7 4.0 g of 2-bromofluorene was added, dispersed in 175 mL of glacial acetic acid, 16 mL of 20percent sulfuric acid, 0.7 g of potassium iodate, 2.24 g of elemental iodine, The reaction was heated at 80 ° C for 24 hours. Close the heating, ice bath cooling reaction, add cold water 165mL dilution reaction mixture, filter, filter cake with tap water to the filtrate colorless.The resulting solid was collected, dried overnight at 60 ° C, 40 mL of a 10: 1 (by volume) mixture of dichloromethane and methanol, 60 ° C oil bath heating under the mixing beating 1 hour, Natural cooling overnight, pumping filter, The solid was vacuum dried at 60 ° C overnight to give compound 2 as a white solid (4.37 g).

Molecular Weight:371.01
XLogP3:4.9
Exact Mass:369.88541
Monoisotopic Mass:369.88541
Heavy Atom Count:15
Complexity:243
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes