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Home > Encyclopedia > N,O-Bis(trimethylsilyl)acetamide

N,O-Bis(trimethylsilyl)acetamide

N,O-Bis(trimethylsilyl)acetamide structure

N,O-Bis(trimethylsilyl)acetamide 

structure
  • CAS No:

    10416-59-8

  • Formula:

    C8H21NOSi2

  • Chemical Name:

    N,O-Bis(trimethylsilyl)acetamide

  • Synonyms:

    Ethanimidic acid,N-(trimethylsilyl)-,trimethylsilyl ester;Acetimidic acid,N-(trimethylsilyl)-,trimethylsilyl ester;N,O-Bis(trimethylsilyl)acetamide;BSA;Bis(trimethylsilyl)acetamide;BSiA;Bis(trimethylsilyl)acetimidate;O,N-Bis(trimethylsilyl)acetamide;LS 7270;N-(Trimethylsilyl)ethanimidic acid trimethylsilyl ester;N-(Trimethylsilyl)acetimidic acid trimethylsilyl ester;Dynasylan BSA;N,O-Di(trimethylsilyl)acetamide;N,O-Bis-trimethylsilylacetoamide

  • Categories:

    Pharmaceutical Intermediates  >  Bulk Drug Intermediates

Description

Clear to yellowish clear liquid liquid which is soluble in many nonpolar and polar aprotic solvents. The trimethylsilyl group is a frequently utilized monofunctional blocking group for protic organic and inorganic materials. As it eliminated during the silylation is neutral acetamide, N,O-Bis(trimethylsilyl)acetamide can be preferably used for substrates which are acid- or base-sensitive. N,O-bis(trimethylsilyl)-acetamide is an effective silylating agent.

N,O-Bis(trimethylsilyl)acetamide Basic Attributes

203.43

203.43

1306669

233-892-7

DTXSID5051525

29310095

Characteristics

21.59000

3.16

Light yellow or beige to brown Crystalline Powder, Crystals and/or Chunks

0.832 g/cm3

-24 °C

71-73 °C @ Press: 35 Torr

53 °F

n 20/D 1.417(lit.)

Miscible with many nonpolar and polar aprotic solvents.

0-6°C

10 hPa (50 °C)

LD50 orally in Rabbit: 1580 mg/kg

Safety Information

II

8

UN 2920 8/PG 2

3

10-14-22-34-40-20/21/22-11

26-36/37/39-45-7/8-43A-36-30-23-16-7/9

AK3000000

C,Xn,F

Stable under normal temperatures and pressures.

P280-P305 + P351 + P338-P310

H226-H302-H314

|Danger|H226 (97.78%): Flammable liquid and vapor [Warning Flammable liquids]|P210, P233, P240, P241, P242, P243, P260, P264, P270, P280, P301+P312, P301+P330+P331, P303+P361+P353, P304+P340, P305+P351+P338, P310, P321, P330, P363, P370+P378, P403+P235, P405, and P501|Aggregated GHS information provided by 90 companies from 9 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

N,O-bis(trimethylsilyl)acetamide

N,O-Bis(trimethylsilyl)acetamide Use and Manufacturing

Uses

Powerful silylation reagent for a wide range of functional groups under mild conditions

Ethanimidic acid, N-(trimethylsilyl)-, trimethylsilyl ester: ACTIVE

Computed Properties

Molecular Weight:203.43
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:203.11616736
Monoisotopic Mass:203.11616736
Topological Polar Surface Area:21.6
Heavy Atom Count:12
Complexity:177
Undefined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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