10,11-Dihydro-alpha-methyl-10-oxo-dibenzo[b,f]thiepin-2-acetic acid
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![10,11-Dihydro-alpha-methyl-10-oxo-dibenzo[b,f]thiepin-2-acetic acid structure](https://file.echemi.com/fileManage/upload/canonicalSmiles/20220812/551e91fafd95463085be24374d302e51.png "10,11-Dihydro-alpha-methyl-10-oxo-dibenzo[b,f]thiepin-2-acetic acid")
10,11-Dihydro-alpha-methyl-10-oxo-dibenzo[b,f]thiepin-2-acetic acid
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CAS No:
74711-43-6
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Formula:
C17H14O3S
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Chemical Name:
10,11-Dihydro-alpha-methyl-10-oxo-dibenzo[b,f]thiepin-2-acetic acid
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Synonyms:
2-(6-oxo-5H-benzo[b][1]benzothiepin-3-yl)propanoic acid;Zaltoprofen/ 10,11-Dihydro-alpha-Methyl-10-oxo-dibenzo[b,f]thiepin-2-acetic acid;Zaltoprofen, >=99%;Salafapinon;Soleton;Dibenzo(B,F)thiepin-2-acetic acid, 10,11-dihydro-alpha-methyl-10-oxo-;Einecs 277-973-5;Zaltoprofen (unspecified)
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CAS No:
Description
Zaltoprofen(CN100) is an inhibitor of COX for treatment of arthritis. Target: COXZaltoprofen, a preferential COX-2 inhibitor, exhibited a potent inhibitory action on the nociceptive responses induced by a retrograde infusion of bradykinin into the right common carotid artery in rats. Zaltoprofen had a moderate inhibitory effect compared with those of the above-mentioned NSAIDs. the inhibitory effect of zaltoprofen on bradykinin-induced nociceptive responses is not explainable by the inhi
Zaltoprofen is an organic molecular entity.|A non-steroidal anti-inflammatory drug approved for use in Japan in 1993.
Off-White to Pale Yellow Solid
ChEBI: Zaltoprofen is an organic molecular entity.
10,11-Dihydro-alpha-methyl-10-oxo-dibenzo[b,f]thiepin-2-acetic acid Basic Attributes
298.36
298.36
277-973-5
DTXSID0049076
Off-White to Pale Yellow
2934.99.4400
Characteristics
79.7
3.5
1.329±0.06 g/cm3(Predicted)
129-1310C
500.5±50.0 °C(Predicted)
256.5±30.1 °C
1.656
Refrigerator
4.21±0.10(Predicted)
Keep in dark place,Sealed in dry,Room Temperature
Safety Information
HQ2526700
P264, P270, P301+P312, P330, P501
H302
|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
Drug Information
Zaltoprofen has known human metabolites that include (2S,3S,4S,5R)-3,4,5-trihydroxy-6-[2-(6-oxo-5H-benzo[b][1]benzothiepin-3-yl)propanoyloxy]oxane-2-carboxylic acid, 10-hydroxy-zaltoprofen, and Zaltoprofen S-oxide.
10,11-Dihydro-alpha-methyl-10-oxo-dibenzo[b,f]thiepin-2-acetic acid Use and Manufacturing
Anti-inflammatory activity resides in (S)-enantiomer.
Zaltoprofen is a non-steroidal anti-inflammatory drug. It inhibits bradykinin-induced pain responses without blocking bradykinin receptors.
Computed Properties
Molecular Weight:298.4
XLogP3:3.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:298.06636548
Monoisotopic Mass:298.06636548
Topological Polar Surface Area:79.7
Heavy Atom Count:21
Complexity:422
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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10,11-Dihydro-alpha-methyl-10-oxo-dibenzo[b,f]thiepin-2-acetic acid
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