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Zaltoprofen

Zaltoprofen structure

CAS No:
74711-43-6
Formula:
C17H14O3S
Chemical Name:
Zaltoprofen
Synonyms:
Dibenzo[b,f]thiepin-2-acetic acid,10,11-dihydro-α-methyl-10-oxo-;10,11-Dihydro-α-methyl-10-oxodibenzo[b,f]thiepin-2-acetic acid;CN 100;Zaltoprofen;CN 100 (antiphlogistic);Soleton;2-(10,11-Dihydro-10-oxodibenzo[b,f]thiepin-2-yl)propionic acid;2-(10-Oxo-10,11-dihydrodibenzo[b,f]thiepin-2-yl)propanoic acid;89482-00-8
Categories:
Biochemical Engineering > Inhibitors

Description

Zaltoprofen(CN100) is an inhibitor of COX for treatment of arthritis. Target: COXZaltoprofen, a preferential COX-2 inhibitor, exhibited a potent inhibitory action on the nociceptive responses induced by a retrograde infusion of bradykinin into the right common carotid artery in rats. Zaltoprofen had a moderate inhibitory effect compared with those of the above-mentioned NSAIDs. the inhibitory effect of zaltoprofen on bradykinin-induced nociceptive responses is not explainable by the inhi

Zaltoprofen is an organic molecular entity.|A non-steroidal anti-inflammatory drug approved for use in Japan in 1993.

Zaltoprofen Basic Attributes

Molecular Weight：

298.36

Exact Mass：

298.36

EC Number：

277-973-5

DSSTox ID：

DTXSID0049076

HScode：

2934999090

Characteristics

PSA：

79.7

XLogP3：

3.5

Density：

1.3±0.1 g/cm3

Melting Point：

130-133 °C

Boiling Point：

500.5°C at 760 mmHg

Flash Point：

256.5±30.1 °C

Refractive Index：

1.656

Storage Conditions：

Refrigerator

Safety Information

RTECS Number：

HQ2526700

Precautionary statement(s)：

P264, P270, P301+P312, P330, P501

Hazard Statements：

H302

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

Drug Information

Metabolism/Metabolites：

Zaltoprofen has known human metabolites that include (2S,3S,4S,5R)-3,4,5-trihydroxy-6-[2-(6-oxo-5H-benzo[b][1]benzothiepin-3-yl)propanoyloxy]oxane-2-carboxylic acid, 10-hydroxy-zaltoprofen, and Zaltoprofen S-oxide.

Zaltoprofen Use and Manufacturing

Anti-inflammatory activity resides in (S)-enantiomer.

Computed Properties

Molecular Weight:298.4
XLogP3:3.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:298.06636548
Monoisotopic Mass:298.06636548
Topological Polar Surface Area:79.7
Heavy Atom Count:21
Complexity:422
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Zaltoprofen

CAS No.: 74711-43-6

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