Propiverine hydrochloride
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Propiverine hydrochloride
structure -
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CAS No:
54556-98-8
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Formula:
C23H29NO3.ClH
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Chemical Name:
Propiverine hydrochloride
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Synonyms:
Benzeneacetic acid,α-phenyl-α-propoxy-,1-methyl-4-piperidinyl ester,hydrochloride (1:1);Benzeneacetic acid,α-phenyl-α-propoxy-,1-methyl-4-piperidinyl ester,hydrochloride;Acetic acid,diphenylpropoxy-,1-methyl-4-piperidyl ester,hydrochloride;Propiverine hydrochloride;Mictonorm;P 4;P 4 (anticholinergic);Mictonetten;Pollarine;1-Methylpiperidin-4-yl 2,2-diphenyl-2-propoxyacetate hydrochloride
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CAS No:
Propiverine hydrochloride Basic Attributes
403.94
403.191437
DC4GZD10H3
172140
DTXSID1046847
2933399090
Characteristics
38.8
4.73410
white to beige
216-218 °C
494.7ºC at 760 mmHg
253ºC
H2O: soluble 5mg/mL, clear (warmed)
-20°C Freezer
LD50 in male, female mice, male, female rats (mg/kg): 36, 36, 22, 25 i.v.; 223, 283, 1632, 1411 s.c.; 410, 323, 1000, 1092 orally (Yamashita)
Safety Information
NONH for all modes of transport
3
37/38-41
26-39
AH3297000
Xi
P261-P280-P305 + P351 + P338
H315-H318-H335
|Danger|H315 (97.62%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P310, P312, P321, P332+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 42 companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Drug Information
Drugs that bind to but do not activate MUSCARINIC RECEPTORS, thereby blocking the actions of endogenous ACETYLCHOLINE or exogenous agonists. Muscarinic antagonists have widespread effects including actions on the iris and ciliary muscle of the eye, the heart and blood vessels, secretions of the respiratory tract, GI system, and salivary glands, GI motility, urinary bladder tone, and the central nervous system. (See all compounds classified as Muscarinic Antagonists.)|Agents that inhibit the actions of the parasympathetic nervous system. The major group of drugs used therapeutically for this purpose is the MUSCARINIC ANTAGONISTS. (See all compounds classified as Parasympatholytics.)|Drugs used in the treatment of urogenital conditions and diseases such as URINARY INCONTINENCE; PROSTATIC HYPERPLASIA; and ERECTILE DYSFUNCTION. (See all compounds classified as Urological Agents.)
alpha-diphenyl alpha-n-propoxyacetic acid-4(1-methylpiperidyl)ester
Propiverine hydrochloride Use and Manufacturing
Propiverine is used in treatment of urinary incontinence. Propiverine is an anticholinergic. It is used for the treatment of frequent urination, urgency and incontinence caused by neurogenic bladder, unstable bladder, bladder irritation (such as chronic cystitis and chronic prostatitis), and has good tolerance.
Computed Properties
Molecular Weight:403.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:8
Exact Mass:403.1914215
Monoisotopic Mass:403.1914215
Topological Polar Surface Area:38.8
Heavy Atom Count:28
Complexity:429
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes
Drug Function and Efficacy
Extract from the above information
Registered Holders
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Hebei Baiqi Pharmaceutical Co., Ltd.
Active
China
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Guizhou Shenqi Pharmaceutical Co., Ltd.
Active
China
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Tianjin Pacific CHEMICAL&PHARMACEUTICAL Co., Ltd.
Active
China
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