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Ranolazine hydrochloride

Ranolazine hydrochloride structure

CAS No:
95635-56-6
Formula:
C24H33N3O4.2ClH
Chemical Name:
Ranolazine hydrochloride
Synonyms:
1-Piperazineacetamide,N-(2,6-dimethylphenyl)-4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]-,hydrochloride (1:2);1-Piperazineacetamide,N-(2,6-dimethylphenyl)-4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]-,dihydrochloride,(±)-;1-Piperazineacetamide,N-(2,6-dimethylphenyl)-4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]-,dihydrochloride;(±)-RS 43285-193;RS 43285;RS 43285-193;Ranolazine hydrochloride;Ranolazine dihydrochloride;110445-25-5;142387-98-2;94386-66-0
Categories:
Biochemical Engineering > Inhibitors

Description

Ranolazine(RS-43285) is an antianginal agent with antiarrhythmic properties that achieves its effects via a novel mechanism of action (inhibition of the late phase of the inward sodium current), without affecting heart rate or blood pressure (BP). IC50 value:Target: sodium-dependent calcium channelRanolazine is currently approved for use in chronic angina. The basis for this use is likely related to inhibition of late sodium channels with resultant beneficial downstream effects. Randomiz

An acetanilide and piperazine derivative that functions as a SODIUM CHANNEL BLOCKER and prevents the release of enzymes during MYOCARDIAL ISCHEMIA. It is used in the treatment of ANGINA PECTORIS.

Ranolazine hydrochloride Basic Attributes

Molecular Weight：

500.46

Exact Mass：

499.200470

HScode：

2942000000

Characteristics

PSA：

74.3

XLogP3：

3.86080

Appearance：

off-white solid

Melting Point：

164-166 °C

Boiling Point：

624.1ºC at 760 mmHg

Flash Point：

331.2ºC

Water Solubility：

H2O: 10 mg/mL, soluble

Storage Conditions：

Desiccate at RT

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

safety instructions：

22-24/25

RTECS Number：

TK7845370

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

Drug Information

MeSH：

A class of drugs that act by inhibition of sodium influx through cell membranes. Blockade of sodium channels slows the rate and amplitude of initial rapid depolarization, reduces cell excitability, and reduces conduction velocity. (See all compounds classified as Sodium Channel Blockers.)|Agents that affect the rate or intensity of cardiac contraction, blood vessel diameter, or blood volume. (See all compounds classified as Cardiovascular Agents.)

MeSH Entry Terms：

43285, RS

Ranolazine hydrochloride Use and Manufacturing

treatment of angina and congestive heart failure

Computed Properties

Molecular Weight:500.5
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:9
Exact Mass:499.2004620
Monoisotopic Mass:499.2004620
Topological Polar Surface Area:74.3
Heavy Atom Count:33
Complexity:531
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:3
Compound Is Canonicalized:Yes

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