(4-Chloro-3-nitrophenyl)(4-fluorophenyl)methanone

1800 g of fluorobenzene and 2250 g of aluminum trichloride are added to the reaction flask, and the cooled acylation solution is added dropwise into the reaction flask, and the temperature is controlled at 25-30 DEG C. After the dropwise addition is completed. , Incubate at 25-30°C for 2 hours. After the reaction was completed, the reaction was added dropwise to 10 Kg of dilute hydrochloric acid (3.0percent concentration). During the process, the controlled temperature did not exceed 65° C. After stirring for 0.5 hours, the reaction was allowed to stand for stratification and the lower organic phase was retained. The organic phase was washed with 600 g of a 10percent strength aqueous sodium carbonate solution. The solvent o-dichlorobenzene was distilled off under reduced pressure, 5400 g of methanol was added to the residue, and the mixture was warmed to reflux. After stirring for 0.5 hours, the temperature was lowered and crystallized. After filtration and drying, the product (3) 2387 g was obtained. The purity was 98.7percent. The total yield is 95.7percent.

Molecular Weight:279.65
XLogP3:3.7
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:279.0098489
Monoisotopic Mass:279.0098489
Topological Polar Surface Area:62.9
Heavy Atom Count:19
Complexity:352
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes