MOPSO

white crystalline powder

Examples of the Good's buffer include, but are not limited to, ...2-morpholinoethanesulfonic acid (MES), N-(2-acetamide) iminodiacetic acid (ADA), piperazine-N, N'-bis(2-ethanesulfonic acid) (PIPES), N-(2-acetamide)-2-aminoethanesulfonic acid (ACES), 3-morpholino-2-hydroxypropanesulfonic acid (MOPSO), 3-morpholinopropanesulfonic acid (MOPS), N-[tris(hydroxymethyl)methyl]-2-aminoethanesulfonic acid (TES), 2-[4-(2-hydroxyethyl)-1-piperazinyl]ethanesulfonic acid (HEPES), ...(1) dehydration cyclization Diethanolamine was added to the reaction kettle, the first diethanolamine temperature rose to 55 , And then add concentrated sulfuric acid, dropping concentrated sulfuric acid when the reactor temperature to be controlled at 57.5 , After the dropwise addition, the temperature was raised to 200 to 240 C, And add sulfuric acid and catalyst:Ni, Cu and MoO3, the mass ratio of Ni, Cu and MoO3 is 1: 3: 4 stirring reaction 750min; (3) filtration, distillationThe neutralized reaction solution was cooled to room temperature and then filtered to remove sodium sulfate. A 1.5% solution of 45% sodium hydroxide was added and the filtrate was mixed and subjected to distillation to collect the fraction. The temperature of the control columnAt 132 C and 162 C; (4) synthesisThe ratio of morpholine to sodium 2-hydroxypropanesulfonate was 1: 1.2, stirred and heated under reflux for 3.5 h. (5) chromatographyThe reaction solution was cooled to room temperature and subjected to sodium ion exchange resin chromatography using 100 g of a strongly acidic styrene cation exchange resin; (6)Eluted with 5% aqueous ammonia, concentrated in vacuo, adjusted to pH = 5.0 with glacial acetic acid, diluted with 10 volumes of ethanol, precipitated as a white solid, filtered, washed with ethanol and dried in vacuo.EXAMPLE 6 3-(N-morpholino)-2-hydroxypropyl sulfonic acid A mixture of 174.24 gms (2 moles) of morpholine, 300 cc. of water and 196.5 gms (1 mole) of sodium-3-chloro-2-hydroxypropyl sulfonate is charged to a 1-liter, 2-neck flask equipped with stirrer and condenser. The suspension is stirred vigorously and refluxed for 3 hours. After cooling to about 25° C., the solution is passed through a column of Dowex 50 in order to remove sodium cations and form the free acid. The elude from the column, containing the product, is evaporated to a thick oil under vacuum. Upon diluting with alcohol, the product, in the form of a zwitterion, crystallizes readily. The product is filtered, washed with alcohol and dried. The yield is 160 gms of a white material melting at 280° C. with decomposition. Analysis of the product indicates a carbon content of 37.38percent, a hydrogen content of 6.74percent, and a nitrogen content of 6.24percent. The calculated values are carbon, 37.3percent; hydrogen, 6.7percent; and nitrogen, 6.2percent. The pKa of this product at 20° C. is 6.95.

Molecular Weight:225.27
XLogP3:-4.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:4
Exact Mass:225.06709375
Monoisotopic Mass:225.06709375
Topological Polar Surface Area:95.4
Heavy Atom Count:14
Complexity:254
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes