Pioglitazone N-oxide
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Pioglitazone N-oxide
structure -
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CAS No:
145350-09-0
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Formula:
C19H20N2O4S
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Chemical Name:
Pioglitazone N-oxide
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CAS No:
Characteristics
106
1.01
white solid
1.3±0.1 g/cm3
158-160ºC
666.3±50.0 °C at 760 mmHg
356.8±30.1 °C
1.640
Computed Properties
Molecular Weight:372.4
XLogP3:2.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:7
Exact Mass:372.11437830
Monoisotopic Mass:372.11437830
Topological Polar Surface Area:106
Heavy Atom Count:26
Complexity:496
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Drug Function and Efficacy
It reduces peripheral and hepatic insulin resistance, increases insulin-dependent glucose processing, and reduces hepatic glucose output; it is a highly selective agonist of peroxisome proliferator-activated receptor γ (PPARγ), activating PPARγ nuclear receptors in tissues such as fat, skeletal muscle and liver where insulin acts, regulating the transcription of insulin-responsive genes, and controlling the production, transport and utilization of blood glucose.
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