Tauroursodeoxycholic acid
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Tauroursodeoxycholic acid
structure -
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CAS No:
14605-22-2
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Formula:
C26H45NO6S
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Chemical Name:
Tauroursodeoxycholic acid
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Synonyms:
Ethanesulfonic acid,2-[[(3α,5β,7β)-3,7-dihydroxy-24-oxocholan-24-yl]amino]-;Taurine,N-(3α,7β-dihydroxy-5β-cholan-24-oyl)-;Tauroursodeoxycholic acid;Cholane,ethanesulfonic acid deriv.;2-[[(3α,5β,7β)-3,7-Dihydroxy-24-oxocholan-24-yl]amino]ethanesulfonic acid;3α,7β-Dihydroxy-5β-cholanoyltaurine;Ursodeoxycholyltaurine;UR 906;Taurolite;Taurursodiol;2-(3α,7β-dihydroxy-5β-cholan-24-amido)ethanesulfonic acid;Ursodoxicoltaurine;130656-42-7
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CAS No:
Description
Tauroursodeoxycholate is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.
Characteristics
132
2.10
White solid
1.2±0.1 g/cm3
173-175°C
496.4ºC at 760mmHg
214.2ºC
1.552
+15C to +30C
Safety Information
NONH for all modes of transport
2
22-24/25
KI7372500
P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501
H315
Tauroursodeoxycholic acid Use and Manufacturing
Tauroursodeoxycholate inhibits human cholangiocarcinoma growth via Ca2+-, PKC-, and MAPK-dependent pathways
Drug Function and Efficacy
It can increase the secretion of bile acid, leading to changes in the composition of bile acid and increasing its content in bile; it can inhibit the synthesis of cholesterol in the liver, reduce the amount of cholesterol and cholesterol ester in bile and the saturation index of cholesterol, thereby facilitating the gradual dissolution of cholesterol in bile.
Registered Holders
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Zhongshan Bailing Biotechnology Co., Ltd.
Active
China
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ICE SPA
Active
United States
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Sichuan MED-SHINE Pharmaceutical Co., Ltd.
Inactive
China
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