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Fenspiride hydrochloride

Fenspiride hydrochloride structure

CAS No:
5053-08-7
Formula:
C15H20N2O2.ClH
Chemical Name:
Fenspiride hydrochloride
Synonyms:
1-Oxa-3,8-diazaspiro[4.5]decan-2-one,8-(2-phenylethyl)-,hydrochloride (1:1);1-Oxa-3,8-diazaspiro[4.5]decan-2-one,8-phenethyl-,monohydrochloride;1-Oxa-3,8-diazaspiro[4.5]decan-2-one,8-(2-phenylethyl)-,monohydrochloride;Fenspiride hydrochloride;JP 428;8-Phenethyl-1-oxa-3,8-diazaspiro[4.5]decan-2-one hydrochloride;Decaspiride;Fluiden;Viarespan;NAT 333;Decaspir;Tegencia;NDR 5998A;Pneumorel;Erespal
Categories:
Biochemical Engineering > Inhibitors

Description

Fenspiride Hcl is an α adrenergic and H1 histamine receptor antagonist.IC50 value:Target: Adrenergic receptor; H1 receptorFenspiride hydrochloride is a bronchodilator with anti-inflammatory properties. Fenspiride hydrochloride inhibits mucus secretion and reduces the release of tachykinins at a prejunctional level. Fenspiride hydrochloride also may be an antagonist at α adrenergic and H1 histamine receptors.

Fenspiride hydrochloride Basic Attributes

Molecular Weight：

296.79

Exact Mass：

296.12900

EC Number：

225-752-9

UNII：

832NBX878V

NSC Number：

757825

DSSTox ID：

DTXSID3045770

Characteristics

PSA：

41.6

XLogP3：

2.87220

Appearance：

white powder

Density：

1.19g/cm3

Melting Point：

235-238°C (dec.)

Boiling Point：

474.3ºC at 760mmHg

Flash Point：

240.6ºC

Water Solubility：

>44.5 [ug/mL]

Storage Conditions：

Refrigerator

Toxicity：

LD50 i.v. in mice: 106 mg/kg; orally in rats: 437 mg/kg (LeDouarec)

Collision Cross Section：

148.9 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

20/21/22

safety instructions：

RTECS Number：

RO0375000

Marks：

Precautionary statement(s)：

P280

Hazard Statements：

H302-H312-H332

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P312, P322, P330, P363, and P501|Aggregated GHS information provided by 42 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Agents that cause an increase in the expansion of a bronchus or bronchial tubes. (See all compounds classified as Bronchodilator Agents.)

MeSH Entry Terms：

3612 S

Fenspiride hydrochloride Use and Manufacturing

Bronchodilator with anti-inflammatory properties. Inhibits mucus secretion and reduces the release of tachykinins at a prejunctional level by its anti-muscarinic action. It also may be an antagonist at α adrenergic and H1 histamine receptors.

Computed Properties

Molecular Weight:296.79
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:296.1291556
Monoisotopic Mass:296.1291556
Topological Polar Surface Area:41.6
Heavy Atom Count:20
Complexity:318
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Recommended Suppliers of Fenspiride hydrochloride

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

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Fenspiride hydrochloride

CAS No.: 5053-08-7

Content: 99.00%

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Xiamen Eagle Chemical Corporation Contact Supplier

CN
2 YRS

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Fenspiride Hcl

Unit Price: $1.1 /KG EXW

CAS No.: 5053-08-7

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Content: 99%

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