Buflomedil pyridoxal phosphate
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Buflomedil pyridoxal phosphate
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CAS No:
104018-07-7
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Formula:
C25H35N2O10P
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Chemical Name:
Buflomedil pyridoxal phosphate
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CAS No:
Drug Information
Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)
2,4,6-trimethoxyphenyl-3-pyrrolidine propyl ketone
Computed Properties
Molecular Weight:554.5
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:12
Rotatable Bond Count:12
Exact Mass:554.20293232
Monoisotopic Mass:554.20293232
Topological Polar Surface Area:165
Heavy Atom Count:38
Complexity:622
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes
Drug Function and Efficacy
It is decomposed into two highly biologically active substances, pyridoxal phosphate and buflomedil, in the body. Compared with buflomedil hydrochloride, pyridoxal phosphate promotes the absorption and utilization of buflomedil in the body. The two have a synergistic effect and enhance the function of inhibiting platelet aggregation. Pyridoxal phosphate participates in the biological metabolism of proteins as a coenzyme of transaminase; it promotes the conversion of cysteine in the damaged vascular endothelium into harmless cystathionine. Buflomedil inhibits α-receptor dilation of microvessels; increases the deformability of red blood cells; blocks calcium ion channels; and reduces tissue oxygen consumption. It can effectively improve the blood and nutrient supply of diseased tissues in the body and accelerate the repair of damaged tissues.
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