Tris(1,3-dichloro-2-propyl) phosphate

430.9

430.90

237-159-2

B1PRV4G0T0

DTXSID9026261

Viscous liquid|Clear liquid

2919900090

54.57000

1.79

Tris(1,3-dichloro-2-propyl)phosphate is a clear colorless viscous liquid. Generally a super-cooled liquid at room temperature but may occasionally solidify when held at low temperatures for prolonged periods. (NTP, 1992)

148 g/cm³ @ Temp: 25 °C

27 °C

236-237 °C @ Press: 5 Torr

249°C

1.497

H2O: <0.1 g/100 mL at 24 ºC

Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.

2.86X10-7 mm Hg at 25 deg C (est)

Mild odor

Henry's Law constant = 2.61X10-9 atm-cu m/mol at 25 °C (est)

178.56 Ų [M+H]+

Decomposes gradually when heated above 200 °C|Hydroxyl radical reaction rate constant = 1.81X10-11 cu cm/molec-sec at 25 °C (est)

Insoluble in water.

Esters, Sulfate Esters, Phosphate Esters, Thiophosphate Esters, and Borate Esters

TRIS(1,3-DICHLORO-2-PROPYL)PHOSPHATE hydrolyzes slowly when refluxed with an aqueous acid. Under alkaline conditions, it exhibits a slow cleavage. It has plasticizing properties and, as such, may soften or deteriorate certain plastics and elastomers (particularly vinyl-based resin, neoprene and natural rubbers). (NTP, 1992)

955 °F (NTP, 1992)

9

UN30829/PG3

20/21/22-36/37/38-51/53-38-20-40

26-36/37/39-61-36/37

UB1473000

Xn,N

Resistant to chlorination in aqueous soln; it has an extremely low rate of hydrolysis & resists attack by bases.

P273-P281

H351-H411

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal and plant life; and conformance with environmental and public health regulations..

Holleman JW; Health Effects of Haloalkyl Phosphate Flame Retardants and Potential Metabolic Products 40pp (1984) REPORT# ISS DOE/NBM-4006848. Tris(1,3-dichloro-2-propyl)phosphate and related compounds ... is reported.

This chemical is combustible. (NTP, 1992)

|Warning|H351: Suspected of causing cancer [Warning Carcinogenicity]|P201, P202, P281, P308+P313, P405, and P501|H351 (94.29%): Suspected of causing cancer [Warning Carcinogenicity]|P201, P202, P273, P281, P308+P313, P391, P405, and P501|Aggregated GHS information provided by 175 companies from 11 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. A water spray may also be used. (NTP, 1992)

SMALL SPILLS AND LEAKAGE: If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION. Then, use absorbent paper to pick up all liquid spill material. Your contaminated clothing and absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. STORAGE PRECAUTIONS: You should store this material under ambient temperatures. (NTP, 1992)

MINIMUM PROTECTIVE CLOTHING: If Tyvek-type disposable protective clothing is not worn during handling of this chemical, wear disposable Tyvek-type sleeves taped to your gloves. RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)|Some data suggesting breakthrough times /for butyl rubber and nitrile rubber/ of approximately an hour or more. /Organo-phosphorus cmpd/

SRP: The scientific literature for the use of contact lenses by industrial workers is inconsistent. The benefits or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

... Fyrol FR-2 can be irritating to the skin and the eyes ... .

Phosphoric acids, including tris(1,3-dichloro-2-propyl) phosphate, were detected in leachate from the Osaka North Port Sea-Based Solid Waste Disposal Site and in the surrounding seawater at a concentration range of 0.1 to 17.0 ug/L(1). Tris(1,3-dichloro-2-propyl) phosphate was detected in the effluent of samples taken from 11 Swedish sewage treatment plants in 2002 to 2003 at 0.13-0.34 ug/L, average 0.23 ug/L. Tris(1,3-dichloro-2-propyl) phosphate was detected in the sewage sludge from these same STPs at 0.0033-0.260 ug/L(2). Tris(1,3-dichloro-2-propyl) phosphate was detected 77.5% of the time in upstream, downstream, and effluent samples from 10 wastewater treatment plants located throughout the United States at a median concentration of 0.2 ug/L, maximum concentration 0.48 ug/L(3). Tris(1,3-dichloro-2-propyl) phosphate was detected in 4 of 4 samples taken at a site 100 yards downstream from where WWTP effluent is discharged into the Assunpink Creek (in the vicinity of Trenton, New Jersey) in 2004 at 110-320 ng/L and in 4 of 4 samples taken at a site two miles further downstream at 54-170 ng/L(4).

URBAN/SUBURBAN: Tris(1,3-dichloro-2-propyl) phosphate was detected in the ambient air of Kitakyushu, Japan in 1983 at 0.0047 ug/cu m(1).|INDOOR AIR: Tris(1,3-dichloro-2-propyl) phosphate was detected in 6 of 12 indoor air samples from locations in and around Zurich (Switzerland), including 3 offices, 2 furniture stores, 3 electronics stores, a theater, and 3 cars, at 23-260 ng/cu m(1). Tris(1,3-dichloro-2-propyl) phosphate was detected in 2 of 29 indoor air samples from various locations in Sweden at 5-7 ng/cu m(2). Tris(1,3-dichloro-2-propyl) phosphate was detected in indoor air environments in Tokyo, Japan: In 18 houses sampled, tris(1,3-dichloro-2-propyl) phosphate concentration ranged from 0-0.60 ng/cu m. In 14 office buildings sampled, tris(1,3-dichloro-2-propyl) phosphate concentration ranged from 0-8.7 ng/cu m. In a newly constructed home in Tokyo, Japan, the indoor air concentration of tris(1,3-dichloro-2-propyl) phosphate was 1.3 ng/cu m. In addition, the migration rate of tris(1,3-dichloro-2-propyl) phosphate was measured as 0.28 ug/sq m-hour from computer monitors(3). Tris(1,3-dichloro-2-propyl) phosphate was detected in dust samples obtained from different private residences (houses) located in the northwest of Spain at an average concentration (ug/g) of 0.35 ug/g(4).

Tris(1,3-dichloro-2-propyl) phosphate was detected in soft polyurethane foam samples at levels of 4.5-10.2 ug/g(1).

LD50 Rat dermal >2000 mg/kg bw|LC50 Rat inhalation >5,220 mg/cu m/ 4hr|LD50 Rat oral <1898-2933 mg/kg bw|LD50 Rat oral >2000 mg/kg bw|For more Non-Human Toxicity Values (Complete) data for TRIS(1,3-DICHLORO-2-PROPYL) PHOSPHATE (8 total), please visit the HSDB record page.

/AQUATIC SPECIES/ After 20 launderings, 37% of flame retardant was lost from polyester sleepwear. Fyrol fr-2 released from unlaundered sleepwear to water at 30 ppm caused death to goldfish within 3 hr. It remained stable in water for 24 hr.

Tris(1,3-dichloro-2-propyl) phosphate's production and use as a flame retardant in plastics and as a secondary plasticizer(1) and former use as a flame retardant in children's sleepwear(2) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 1100(SRC), determined from a log Kow of 3.65(2) and a regression-derived equation(3), indicates that tris(1,3-dichloro-2-propyl) phosphate is expected to have slight mobility in soil(SRC). Volatilization of tris(1,3-dichloro-2-propyl) phosphate from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 2.6X10-9 atm-cu m/mole(SRC), using a fragment constant estimation method(4). Tris(1,3-dichloro-2-propyl) phosphate is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 2.9X10-7 mm Hg at 25 °C(SRC), determined from a fragment constant method(3). Utilizing the Japanese MITI test, 0-4% of the Theoretical BOD was reached in 4 weeks(5) indicating that biodegradation is not an important environmental fate process in soil(SRC).|AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 1100(SRC), determined from a log Kow of 3.65(2) and a regression-derived equation(3), indicates that tris(1,3-dichloro-2-propyl) phosphate is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(4) based upon an estimated Henry's Law constant of 2.6X10-9 atm-cu m/mole(SRC), developed using a fragment constant estimation method(5). Production data suggest that tris(1,3-dichloro-2-propyl) phosphate will be resistant to hydrolysis in most environmental waters(6). According to a classification scheme(7), a BCF range of 0.3-113 (2,8,9) suggests bioconcentration in aquatic organisms is low to moderate(SRC). Utilizing the Japanese MITI test, 0-4% of the Theoretical BOD was reached in 4 weeks(2) indicating that biodegradation is not an important environmental fate process in water(SRC).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), tris(1,3-dichloro-2-propyl) phosphate, which has an estimated vapor pressure of 2.9X10-7 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase tris(1,3-dichloro-2-propyl) phosphate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 21.3 hrs(SRC), calculated from its rate constant of 1.8X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Particulate-phase tris(1,3-dichloro-2-propyl) phosphate may be removed from the air by wet and dry deposition(SRC). Tris(1,3-dichloro-2-propyl) phosphate does not contain chromophores that absorb at wavelengths >290 nm(4) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC).

The rate constant for the vapor-phase reaction of tris(1,3-dichloro-2-propyl) phosphate with photochemically-produced hydroxyl radicals has been estimated as 18.1X10-12 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). Hydrolysis of phosphate esters is highly pH-dependent and they are generally resistant to hydrolysis in neutral or acidic water (pH 5.0-7.0), but readily degrade in more alkaline conditions (pH 9.0-9.5)(2). Product literature suggests that tris(1,3-dichloro-2-propyl) phosphate will be resistant to hydrolysis in most environmental waters (3). Tris(1,3-dichloro-2-propyl) phosphate does not contain chromophores that absorb at wavelengths >290 nm(4) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC).

12.02|BCFs of 3-5 and 77-113 were measured for tris(1,3-dichloro-2-propyl) phosphate using goldfish (Carassius auratus) and Japanese medaka (Oryzias latipes), respectively, which were exposed over 24 and 96 hr periods(1). A BCF of 50-89 was measured for tris(1,3-dichloro-2-propyl) phosphate using Japanese medaka (Oryzias latipes) which were exposed over a 38 day period(2). A BCF of 0.30-3.3 was measured for tris(1,3-dichloro-2-propyl) phosphate using carp (Cyprinus carpio)(3). According to a classification scheme(4), BCF values of zero to 30 are low and from 100 to 1,000 are high.

The Koc of tris(1,3-dichloro-2-propyl) phosphate is estimated as 1100(SRC), using a log Kow of 3.65(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that tris(1,3-dichloro-2-propyl) phosphate is expected to have slight mobility in soil.

The Henry's Law constant for tris(1,3-dichloro-2-propyl) phosphate is estimated as 2.61X10-9 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This Henry's Law constant indicates that tris(1,3-dichloro-2-propyl) phosphate is expected to be essentially nonvolatile from water and moist soil surfaces(2). Tris(1,3-dichloro-2-propyl) phosphate is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 2.9X10-7 mm Hg(SRC), determined from a fragment constant method(3).

GROUND WATER: Tris(1,3-dichloro-2-propyl) phosphate was detected in 12.2% of samples taken from 25 ground- and 49 surface-water sources used for public drinking water systems from 25 different US states and Puerto Rico; however, the detection level was always below the reporting limit of 0.5 ug/L(1). Tris(1,3-dichloro-2-propyl) phosphate was detected in 2.1% of groundwater samples from 47 sites in 18 different states as part of a US national reconnaissance program of water quality in the United States; however, all detections were below the reporting level(2).|DRINKING WATER: Tris(1,3-dichloro-2-propyl) phosphate was detected in 100% of 12 drinking water supplies from Great Lakes municipalities in Canada in 1980, at concentrations ranging from 0.4 to 15.7 ng/L during the month of Jan and from 0.1 to 4.6 ng/L for Aug(1). Tris(1,3-dichloro-2-propyl) phosphate was detected in drinking water from six eastern Ontario municipal water treatment plants in 1978 at 0.2-1.8 ng/L(2). Tris(1,3-dichloro-2-propyl) phosphate was detected in 14 of 29 municipal water supplies representing the major urban centers across Canada at 0.3-23.0 ng/L(3). Tris(1,3-dichloro-2-propyl) phosphate was detected in drainage basins drinking water supplies at mean concentrations of 0.0 ng/L for the Pacific Sea Board and the Columbia, 0.1 ng/L for the Atlantic Sea Board, 1.7 ng/L at Lake Winnipeg, 2.4 ng/L at Great lakes, and 3.1 ng/L for the St. Lawrence River. Tris(1,3-dichloro-2-propyl) phosphate was detected in the sources for these drainage basins at average levels of 3.7, 0.3, and 0.0 ng/L for rivers, lakes, and wells, respectively(3). Tris(1,3-dichloro-2-propyl) phosphate was detected in surface water from the river Ruhr (Germany) used for a drinking water works at 8.6-18 ng/L, average 13 ng/L(4). Tris(1,3-dichloro-2-propyl) phosphate was detected in the finished water after several purification steps at 1.2-2.4 ng/L, average 2.6 ng/L; elimination was attributed to activated carbon filtration as well as to a 10-15 day passage time through soil(4). Ozonization and multilayer filtration did not contribute to the removal of tris(1,3-dichloro-2-propyl) phosphate(4).|SURFACE WATER: Tris(1,3-dichloro-2-propyl) phosphate was detected in 12.9% of 85 samples from streams located throughout the United States in 1999-2000 at a median concentration of 0.1 ug/L, maximum concentration 0.16 ug/L(1). Tris(1,3-dichloro-2-propyl) phosphate was detected in 16.7% of 30 low-flow samples collected upstream and downstream of towns and cities in Iowa in 2001 at a maximum concentration of 0.4 ug/L; tris(1,3-dichloro-2-propyl) phosphate was not detected in any high-flow (n = 23) or normal-flow samples (n = 23) in the same study(2). Tris(1,3-dichloro-2-propyl) phosphate was detected in 100% of 12 samples of stream and raw water for a drinking-water-treatment facility in a heavy populated, highly urbanized drainage basin in the United States at a 0.06-0.25 ug/L(3). Tris(1,3-dichloro-2-propyl) phosphate was detected 2 of 6 agricultural runoff samples from fields irrigated with treated effluent in Ventura County, California in July 1999-April 2000(4). Tris(1,3-dichloro-2-propyl) phosphate was detected in both polluted areas and less-polluted areas of the Yodo River (Japan) from 1976 to 1990 at ca. 0.1-0.9 ug/L and ca. 0-0.7 ug/L, respectively, with the concentration gradually increasing from 1976-1987 and decreasing from 1988-1990(5). Tris(1,3-dichloro-2-propyl) phosphate was detected in three volcanic lakes located in Central Italy from June 2006-June 2007. The mean monthly range of concentration at all three lakes was 2-60 ng/L with the maximum occurring during the late summer to autumn months. Due to their location, the lakes lack emissaries and tributaries and sewage treatment plant inputs. Therefore, contamination can occur only via local anthropogenic activities or long-range transport and deposition from rainfall or runoff processes(6).|RAIN/SNOW/FOG: Tris(1,3-dichloro-2-propyl) phosphate was detected in snow samples taken from a road intersection in northern Sweden in 2003 at 12, 230, and 8 ng/kg snow at distances of 2, 100, and 250 m from the intersection respectively. Tris(1,3-dichloro-2-propyl) phosphate was detected in 3 of 3 snow samples taken from a Swedish municipal airport at 4-15 ng/kg snow in the same study(1).

Tris(1,3-dichloro-2-propyl) phosphate was tested for but not detected in market basket samples collected in grocery stores from 30 different sectors of the US(1).

According to the 2006 TSCA Inventory Update Reporting data, the number of persons reasonably likely to be exposed in the industrial manufacturing, processing, and use of tris(1,3-dichloro-2-propyl) phosphate is 100-999; the data may be greatly underestimated(1)|Occupational exposure to tris(1,3-dichloro-2-propyl) phosphate may occur through inhalation and dermal contact with this compound at workplaces where tris(1,3-dichloro-2-propyl) phosphate is produced or used. Monitoring and use data indicate that the general population may be exposed to tris(1,3-dichloro-2-propyl) phosphate via inhalation of ambient air, ingestion of drinking water and dermal contact with consumer products containing tris(1,3-dichloro-2-propyl) phosphate. (SRC)

Tris(1,3-dichloro-2-propyl) phosphate was detected in 34 of 123 extracts of human seminal plasma obtained from student donors(1). Tris(1,3-dichloro-2-propyl) phosphate was detected in 5 of 16 human adipose tissue samples obtained from cadavers at autopsy in the range of 0.5-110 ng/g(2).

C-labeled Fyrol FR-2 was readily absorbed from skin and GI tract of rats and rapidly distributed throughout body. Route of admin had little effect on distribution. Absorption and distribution were unaffected over dose range of 2 orders of magnitude.|Six hr after admin (94.4 umol/kg, iv) of u-(14)C-labeled tris(1,3-dichloro-2-propyl) phosphate, there were varying amt in liver, kidney, muscle, nucleic acids, and protein isolated from each tissue. Highest concn in liver. In each tissue, highest concn of bound radioactivity was in low mol wt RNA, with decr concn in protein, RNA, and DNA.|Five days after iv admin of (14)C-tris(1,3-dichloro-2-propyl) phosphate (TDCP) to sprague dawley rats, 92% of admin radiolabel was excreted; 54% in urine, 16% in feces, & 22% in expired air; 4% was recovered in the body. Less than 0.1% of admin dose was recovered as tris(1,3-dichloro-2-propyl) phosphate in excreta. TDCP was eliminated primarily by rapid metabolism whereas the slowly metabolized bis(1,3-dichloro-2-propyl)phosphate was eliminated by excretion. Major portion of radiolabel excreted in bile underwent enterohepatic recirculation.|In continuous flow test system tris(1,3-dichloro-2-propyl) phosphate was taken up rapidly by killifish reaching max on 1st day & levels were maintained until last day of exposure. Elimination was very fast.|For more Absorption, Distribution and Excretion (Complete) data for TRIS(1,3-DICHLORO-2-PROPYL) PHOSPHATE (7 total), please visit the HSDB record page.

Five days after iv admin of (14)C-tris(1,3-dichloro-2-propyl) phosphate to Sprague-Dawley rats, 22% was excreted in expired air as (14)CO2. Major urinary, fecal, and biliary metabolite was bis(1,3-dichloro-2-propyl)phosphate. Other metabolites include the mono ester, 1,3-dichloro-2-propyl phosphate, and 1,3-dichloro-2-propanol.|Tris(1,3-dichloro-2-propyl)phosphate (Tris-CP) was metabolized to products which were mutagenic for Salmonella typhimurium TA100 in the presence of liver microsomes from phenobarbital (PB) pretreated rats and reduced nicotinamide adenine dinucleotide. ...|TDCPP was rapidly metabolized in vitro by an NADPH-dependent microsomal mixed-function oxidase system & glutathione S-transferases from rat liver to BDCPP, 1,3-dichloro-2-propanol, 3-chloro-1,2-propanediol, & one metabolite which was probably a glutathione conjugate.

0.30 Days

SYMPTOMS: Symptoms of exposure to this compound may include irritation of the skin and respiratory tract, breathing difficulty and pulmonary edema. ACUTE/CHRONIC HAZARDS: This compound may cause irritation of the skin and respiratory tract. When heated to decomposition it emits toxic fumes of chlorine, phosphorus oxides and hydrogen chloride gas. This compound is a CHOLINESTERASE INHIBITOR. (NTP, 1992)

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, administer a slurry of activated charcoal in water and simultaneously call a hospital or poison control center. IMMEDIATELY transport the victim to a hospital. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

/SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on the left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Poisons A and B/|/SRP:/ Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Cover skin burns with dry sterile dressings after decontamination ... . /Poisons A and B/|/SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag valve mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Consider administering a beta agonist such as albuterol for severe bronchospasm ... . Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam or lorazepam ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Poisons A and B/

/HUMAN EXPOSURE STUDIES/ Organophosphate (OP) compounds, such as tris(1,3-dichloro-2-propyl) phosphate (TDCPP) and triphenyl phosphate (TPP), are commonly used as additive flame retardants and plasticizers in a wide range of materials. ... /Researchers/ explored relationships of TDCPP and TPP concentrations in house dust with hormone levels and semen quality parameters. /They/ analyzed house dust from 50 men recruited through a U.S. infertility clinic for TDCPP and TPP. Relationships with reproductive and thyroid hormone levels, as well as semen quality parameters, were assessed using crude and multivariable linear regression. TDCPP and TPP were detected in 96% and 98% of samples, respectively, with widely varying concentrations up to 1.8 mg/g. In models adjusted for age and body mass index, an interquartile range (IQR) increase in TDCPP was associated with a 3% [95% confidence interval (CI), 5% to 1%) decline in free thyroxine and a 17% (95% CI, 432%) increase in prolactin. There was a suggestive inverse association between TDCPP and free androgen index that became less evident in adjusted models. ... OP flame retardants may be associated with altered hormone levels and decreased semen quality in men. ...|/EPIDEMIOLOGY STUDIES/ During 1981 workers at a TDCPP manufacturing plant in the USA had their health assessed in physical exams. The health reports of 93 potentially exposed workers from the factory were compared with the health reports of 31 non-exposed workers who were matched for age, alcohol consumption and smoking habits. The 2 groups of workers were comparable with regard to chest X-ray results. Exposed workers had a 2-fold incr in the prevalence of "abnormal" EKG, but fewer exposed workers had a history of heart disease. There were no significant differences in any of the clinical chemistry parameters investigated. The prevalence of minor respiratory disease was slightly incr in exposed workers. The results of the study did not reveal any significantly incr morbidity in workers exposed to TDCPP.

Fyrol FR 2

All other chemical product and preparation manufacturing|2-Propanol, 1,3-dichloro-, 2,2',2''-phosphate: ACTIVE|Flame retardant formerly used in children's sleepwear; once considered as a potential replacement for/ tris(2,3-dibromo-1-propyl) phosphate/.|Fyrol /is/ trademark for series of phosphate flame retardant plasticizers.

Method: USGS-NWQL O-1433-01; Procedure: gas chromatography/mass spectrometry; Analyte: tri(dichloroisopropyl) phosphate; Matrix: filtered wastewater and natural-water samples; Detection Limit: 0.08 ug/L.|A fabric sample from children's pajamas was extracted in acetone and resulting extracts analyzed by nuclear magnetic resonance (nmr).|Food samples (meats, dairy products, fruits, and root vegetables) were anlayzed for various phosphate residues incl tris(1,3-dichloro-2-propyl) phosphate by gas chromatography equipped with flame photometric or nitrogen/phosphorus detectors.