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Bilobalide

Bilobalide structure

CAS No:
33570-04-6
Formula:
C15H18O8
Chemical Name:
Bilobalide
Synonyms:
4H,5aH,9H-Furo[2,3-b]furo[3′,2′:2,3]cyclopenta[1,2-c]furan-2,4,7(3H,8H)-trione,9-(1,1-dimethylethyl)-10,10a-dihydro-8,9-dihydroxy-,(3aS,5aR,8R,8aS,9R,10aS)-;4H,5aH,9H-Furo[2,3-b]furo[3′,2′:2,3]cyclopenta[1,2-c]furan-2,4,7(3H,8H)-trione,9-(1,1-dimethylethyl)-10,10a-dihydro-8,9-dihydroxy-,[5aR-(3aS*,5aα,8β,8aS*,9α,10aα)]-;4H,5aH,9H-Furo[2,3-b]furo[3′,2′:2,3]cyclopenta[1,2-c]furan-2,4,7(3H,8H)-trione,9α-tert-butyl-10,10aβ-dihydro-8α,9-dihydroxy-,(-)-;(3aS,5aR,8R,8aS,9R,10aS)-9-(1,1-Dimethylethyl)-10,10a-dihydro-8,9-dihydroxy-4H,5aH,9H-furo[2,3-b]furo[3′,2′:2,3]cyclopenta[1,2-c]furan-2,4,7(3H,8H)-trione;Bilobalide;Bilobalid;(-)-Bilobalide
Categories:
Biochemical Engineering > Chinese Herbs

Description

Bilobalide is a biologically active terpenic trilactone present in Ginkgo biloba. An increasing number of studies have demonstrated its neuroprotective effects.IC50 Value: 3.33 (pIC50 Value) [1]Target: neuroprotectivein vitro: Inhibition by BB and GB was abolished in mutant receptors containing T6'S and S12'A substitutions, but their potencies were enhanced (42- and 125-fold, respectively) in S2'A mutant receptors [1]. BB enhanced the secretion of α-secretase-cleaved soluble amyloid prec

Bilobalide is a terpenoid trilactone found in extracts of Ginkgo biloba.

Bilobalide Basic Attributes

Molecular Weight：

326.3

Exact Mass：

326.30

EC Number：

608-892-9

UNII：

M81D2O8H7U

HScode：

29322090

Characteristics

PSA：

119.36000

XLogP3：

-0.45

Appearance：

White solid

Density：

1.6±0.1 g/cm3

Melting Point：

>300°

Boiling Point：

651.7±55.0 °C at 760 mmHg

Flash Point：

247.5±25.0 °C

Refractive Index：

1.606

Storage Conditions：

−20°C

Specific rotation：

57820 -64.3° (c = 2 in acetone)

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

safety instructions：

24/25

RTECS Number：

LV1665000

Drug Information

MeSH Entry Terms：

(-)-bilobalide

Computed Properties

Molecular Weight:326.30
XLogP3:-0.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:1
Exact Mass:326.10016753
Monoisotopic Mass:326.10016753
Topological Polar Surface Area:119
Heavy Atom Count:23
Complexity:650
Defined Atom Stereocenter Count:6
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Related Drugs

Ginkgo Leaf Drops
Ingredients	Each milliliter is labeled to contain 9.6 mg of ginkgo flavonoids, 2.4 mg of terpenes, ginkgo lactones, and ginkgo biloba.
Indication	Drug interactions may occur if used with other drugs. Please consult your doctor or pharmacist for details.
Specifications	36ml (drops)
Manufacturer	Shandong Xianhe Pharmaceutical Co., Ltd.

Ginkgo biloba extract tablets
Ingredients	Each tablet contains 4 mg of ginkgo leaf extract, including 9.6 mg of ginkgo flavonoids and 2.4 mg of terpene lactones (ginkgolides and bilobalide).
Indication	Each tablet contains 4 mg of ginkgo leaf extract, including 9.6 mg of ginkgo flavonoids and 2.4 mg of terpene lactones (ginkgolides and bilobalide).
Specifications	40mg x 10 tablets x 2 plates film coated

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Guide of Bilobalide

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Computed Properties
Related Drugs
Recommended Suppliers
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Bilobalide

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