Bilobalide
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Bilobalide
structure -
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CAS No:
33570-04-6
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Formula:
C15H18O8
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Chemical Name:
Bilobalide
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Synonyms:
4H,5aH,9H-Furo[2,3-b]furo[3′,2′:2,3]cyclopenta[1,2-c]furan-2,4,7(3H,8H)-trione,9-(1,1-dimethylethyl)-10,10a-dihydro-8,9-dihydroxy-,(3aS,5aR,8R,8aS,9R,10aS)-;4H,5aH,9H-Furo[2,3-b]furo[3′,2′:2,3]cyclopenta[1,2-c]furan-2,4,7(3H,8H)-trione,9-(1,1-dimethylethyl)-10,10a-dihydro-8,9-dihydroxy-,[5aR-(3aS*,5aα,8β,8aS*,9α,10aα)]-;4H,5aH,9H-Furo[2,3-b]furo[3′,2′:2,3]cyclopenta[1,2-c]furan-2,4,7(3H,8H)-trione,9α-tert-butyl-10,10aβ-dihydro-8α,9-dihydroxy-,(-)-;(3aS,5aR,8R,8aS,9R,10aS)-9-(1,1-Dimethylethyl)-10,10a-dihydro-8,9-dihydroxy-4H,5aH,9H-furo[2,3-b]furo[3′,2′:2,3]cyclopenta[1,2-c]furan-2,4,7(3H,8H)-trione;Bilobalide;Bilobalid;(-)-Bilobalide
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CAS No:
Description
Bilobalide is a biologically active terpenic trilactone present in Ginkgo biloba. An increasing number of studies have demonstrated its neuroprotective effects.IC50 Value: 3.33 (pIC50 Value) [1]Target: neuroprotectivein vitro: Inhibition by BB and GB was abolished in mutant receptors containing T6'S and S12'A substitutions, but their potencies were enhanced (42- and 125-fold, respectively) in S2'A mutant receptors [1]. BB enhanced the secretion of α-secretase-cleaved soluble amyloid prec
Bilobalide is a terpenoid trilactone found in extracts of Ginkgo biloba.
Characteristics
119.36000
-0.45
White solid
1.6±0.1 g/cm3
>300°
651.7±55.0 °C at 760 mmHg
247.5±25.0 °C
1.606
−20°C
57820 -64.3° (c = 2 in acetone)
Computed Properties
Molecular Weight:326.30
XLogP3:-0.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:1
Exact Mass:326.10016753
Monoisotopic Mass:326.10016753
Topological Polar Surface Area:119
Heavy Atom Count:23
Complexity:650
Defined Atom Stereocenter Count:6
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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