 Home > Encyclopedia > Vardenafil hydrochloride

Vardenafil hydrochloride

Vardenafil hydrochloride structure

CAS No:
224785-91-5
Formula:
C23H32N6O4S.ClH
Chemical Name:
Vardenafil hydrochloride
Synonyms:
Imidazo[5,1-f][1,2,4]triazin-4(1H)-one,2-[2-ethoxy-5-[(4-ethyl-1-piperazinyl)sulfonyl]phenyl]-5-methyl-7-propyl-,hydrochloride (1:1);Piperazine,1-[[3-(1,4-dihydro-5-methyl-4-oxo-7-propylimidazo[5,1-f][1,2,4]triazin-2-yl)-4-ethoxyphenyl]sulfonyl]-4-ethyl-,monohydrochloride;Levitra;Vardenafil hydrochloride;1437791-29-1
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

Vardenafil Hcl is a PDE5 inhibitor used for treating erectile dysfunction.Target: PDE5Vardenafil specifically inhibited the hydrolysis of cGMP by PDE5 with an IC50 of 0.7 nM (6.6 nM). In contrast, the IC50 of vardenafil for PDE1 was 180 nM; for PDE6, 11 nM; for PDE2, PDE3 and PDE4, more than 1000 nM. Relative to PDE5, the ratios of the IC50 for PDE1 were 257 (60), for PDE6 16 (7.4). Vardenafil significantly enhanced the SNP-induced relaxation of human trabecular smooth muscle at 3 nM (10

Vardenafil hydrochloride Basic Attributes

Molecular Weight：

525.065

Exact Mass：

524.197266

EC Number：

607-088-5

Characteristics

PSA：

118

XLogP3：

3.82900

Appearance：

White to Off-White Cyrstalline Solid

Melting Point：

214-216ºC

Boiling Point：

692.2ºC at 760 mmHg

Flash Point：

372.5ºC

Water Solubility：

In water, 3.5 mg/L at 25 °C /Estimated/

Vapor Pressure：

3.4X10-19 mm Hg at 25 °C /Estimated/

Safety Information

Precautionary statement(s)：

P264, P270, P301+P312, P330, P501

Hazard Statements：

H302

Vardenafil hydrochloride Use and Manufacturing

A selective phsphodiesterase type 5 (PDE5) inhibitor A phsphodiesterase 5 inhibitor.

Drug Function and Efficacy

Vardenafil increases the release of local endogenous nitric oxide in the corpus cavernosum under sexual stimulation by inhibiting phosphodiesterase type 5 (PDE5) that degrades cGMP in the human corpus cavernosum, thereby enhancing the natural response to sexual stimulation.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Vardenafil Hydrochloride Tablets
Ingredients	The main ingredient of this product is vardenafil hydrochloride.
Indication	CYP inhibitors: Vardenafil is primarily metabolized by the liver enzyme system via cytochrome P450 (CYP) isoenzyme 3A4, with CYP3A5 and CYP2C isoenzymes playing a role in its metabolism. Therefore, inhibitors of these enzymes may reduce the clearance of vardenafil.
Specifications	10 mg

Vardenafil Hydrochloride Tablets
Ingredients	Vardenafil hydrochloride. Molecular weight: C23H32N6O4S.HCL.3H2O
Indication	Drug interactions may occur if used with other drugs. Please consult your doctor or pharmacist for details.
Specifications	20mg

Vardenafil Hydrochloride Tablets
Ingredients	The main ingredient of this product is vardenafil hydrochloride.
Indication	CYP inhibitors: Vardenafil is primarily metabolized by the liver enzyme system via cytochrome P450 (CYP) isoenzyme 3A4, with CYP3A5 and CYP2C isoenzymes playing a role in its metabolism. Therefore, inhibitors of these enzymes may reduce the clearance of vardenafil.
Specifications	20 mg

See More Related Drugs

Registered Holders

Yangling Jitai Pharmaceutical Co., Ltd.

China
Active
Shanghai SynTheAll Pharmaceutical Co., Ltd.

China
Active
Guangzhou Greensyn Pharma Co., Ltd.

China
Active

See More Registered Holders