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Navelbine

Navelbine structure

CAS No:
125317-39-7
Formula:
C45H54N4O8.2C4H6O6
Chemical Name:
Navelbine
Synonyms:
Aspidospermidine-3-carboxylic acid,4-(acetyloxy)-6,7-didehydro-15-[(2R,6R,8S)-4-ethyl-1,3,6,7,8,9-hexahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-,methyl ester,(2β,3β,4β,5α,12R,19α)-,(2R,3R)-2,3-dihydroxybutanedioate (1:2) (salt);C′-Norvincaleukoblastine,3′,4′-didehydro-4′-deoxy-,[R-(R*,R*)]-2,3-dihydroxybutanedioate (1:2) (salt);Vinorelbine ditartrate;KW 2307;Navelbine ditartrate;Vinorelbine tartrate;Navelbine;Nor-5′-anhydrovinblastine ditartrate;Aspidospermidine-3-carboxylic acid,4-(acetyloxy)-6,7-didehydro-15-[(2R,6R,8S)-4-ethyl-1,3,6,7,8,9-hexahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-,methyl ester,(2β,3β,4β,5α,12β,19α)-,(2R,3R)-2,3-dihydroxybutanedioate (1:2) (salt);3′,4′-Didehydro-4′-deoxy-C′-norvincaleukoblastine tartrate;892125-21-2
Categories:
Active Pharmaceutical Ingredients > Antineoplastic Agents

Description

Vinorelbine (ditartrate) is an anti-mitotic agent which inhibits the proliferation of Hela cells with IC50 of 1.25 nM.

A vinca alkaloid related to VINBLASTINE that is used as a first-line treatment for NON-SMALL CELL LUNG CANCER, or for advanced or metastatic BREAST CANCER refractory to treatment with ANTHRACYCLINES.

Navelbine Basic Attributes

Molecular Weight：

1079.11

Exact Mass：

1078.427002

EC Number：

1806241-263-5

DSSTox ID：

DTXSID5047825

HScode：

2942000000

Characteristics

PSA：

364

XLogP3：

0.44920

Appearance：

off-white powder

Density：

1.36g/cm3

Melting Point：

190 °C

Refractive Index：

1.675

Water Solubility：

H2O: 10 mg/mL

Storage Conditions：

2-8°C

Safety Information

Transport codes：

UN 1544PSN1 6.1 / PGII

wgk germany：

hazard class code：

safety instructions：

26-36

Marks：

GHS Classification：

|Danger|H301 (93.33%): Toxic if swallowed [Danger Acute toxicity, oral]|P201, P202, P260, P264, P270, P280, P281, P301+P310, P302+P352, P305+P351+P338, P308+P313, P314, P321, P330, P332+P313, P337+P313, P362, P405, and P501|Aggregated GHS information provided by 60 companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Agents obtained from higher plants that have demonstrable cytostatic or antineoplastic activity. (See all compounds classified as Antineoplastic Agents, Phytogenic.)|Agents that interact with TUBULIN to inhibit or promote polymerization of MICROTUBULES. (See all compounds classified as Tubulin Modulators.)

MeSH Entry Terms：

5' Nor anhydrovinblastine

Navelbine Use and Manufacturing

Uses

An antineoplastic

Use Classification：

Human drugs -> Rare disease (orphan)|Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:1079.1
Hydrogen Bond Donor Count:10
Hydrogen Bond Acceptor Count:23
Rotatable Bond Count:16
Exact Mass:1078.42704051
Monoisotopic Mass:1078.42704051
Topological Polar Surface Area:364
Heavy Atom Count:77
Complexity:1820
Defined Atom Stereocenter Count:11
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:3
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Extract from the above information

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Vinorelbine tartrate
Manufacturer	Zhejiang Hisun Pharmaceutical Co., Ltd.

Vinorelbine tartrate soft capsules
Specifications	20mg

Vinorelbine tartrate
Manufacturer	Qilu Pharmaceutical Co., Ltd.

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Registered Holders

MINAKEM HIGH POTENT

Belgium
Active
PIERRE FABRE MEDICAMENT

France
Active
Minsheng Group Shaoxing Pharmaceutical Co., Ltd.

China
Active

See More Registered Holders

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