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Hypoxanthine

Hypoxanthine structure

CAS No:
68-94-0
Formula:
C5H4N4O
Chemical Name:
Hypoxanthine
Synonyms:
6H-Purin-6-one,1,9-dihydro-;Hypoxanthine;6H-Purin-6-one,1,7-dihydro-;1,9-Dihydro-6H-purin-6-one;Purin-6(3H)-one;9H-Purin-6(1H)-one;Sarcine;Sarkin;Sarkine;Purin-6(1H)-one;6-Hydroxypurine;6-Oxopurine;6-Hydroxy-1H-purine;9H-Purin-6-ol;Purin-6-ol;3H-Purin-6-ol;Hypoxanthine enol;1H,7H-Hypoxanthine;NSC 129419;NSC 14665;1H,9H-Hypoxanthine;1H-Purin-6(9H)-one;1,9-Dihydro-purin-6-one;480-99-9;6535-89-3;25991-09-7;25991-08-6;25991-07-5;39464-17-0;39464-15-8;184856-40-4;51953-23-2;184856-41-5
Categories:
Biochemical Engineering > Plant Extracts

Description

Hypoxanthine, a purine derivative, is a potential free radical generator and could be used as an indicator of hypoxia.

Solid

Hypoxanthine is a purine nucleobase that consists of purine bearing an oxo substituent at position 6. It has a role as a fundamental metabolite. It is an oxopurine, a purine nucleobase and a nucleobase analogue. It derives from an adenine.|Hypoxanthine is a purine and a reaction intermediate in the metabolism of adenosine and in the formation of nucleic acids by the salvage pathway.|Hypoxanthine is a purine-based organic compound in human muscle tissues, Hypoxanthine is formed during purine catabolism as a product of xanthine oxidase action on xanthine, and occasionally is found as a constituent of nucleic acids. The potent anti-inflammatory and cytoprotective effects of purines may be mediated by cell surface adenosine receptors. Hypoxanthine protects against oxidant-induced cell injury by inhibiting activation of nuclear poly(ADP-ribose) polymerase (PARP). (NCI04)|A purine and a reaction intermediate in the metabolism of adenosine and in the formation of nucleic acids by the salvage pathway.

Hypoxanthine Basic Attributes

Molecular Weight：

136.11

Exact Mass：

136.11

BRN：

5811

EC Number：

200-697-3

UNII：

2TN51YD919

NSC Number：

14665

DSSTox ID：

DTXSID8045983

NCI Thesaurus Code：

C29105

HScode：

2933990090

Characteristics

PSA：

70.1

XLogP3：

-1.1

Appearance：

Colorless to yellow to brown, darken on storage with no loss of purity powder

Density：

1.7±0.1 g/cm3

Melting Point：

150 °C (decomp)

Boiling Point：

533.4°C at 760 mmHg

Flash Point：

287.0±24.6 °C

Refractive Index：

1.816

Water Solubility：

Practically insoluble in water;1 M NaOH: 25 mg/mL

Storage Conditions：

2-8°C

Toxicity：

LD50 intraperitoneal in mouse: 750mg/kg

Collision Cross Section：

127.1 Å² [M+H]+ [CCS Type: DT, Method: single field calibrated with Agilent tune mix (Agilent)]|135.79 Å² [M+H]+ [CCS Type: DT, Method: stepped-field]|138.88 Å² [M+Na]+ [CCS Type: DT, Method: stepped-field]|126.38 Å² [M-H]- [CCS Type: DT, Method: stepped-field]|120 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine]|127.2 Å² [M+H]+ [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|134.4 Å² [M+Na]+ [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|116.9 Å² [M-H]- [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|134.4 Å² [M+Na-2H]- [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|123.1 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]|135 Å² [M-2H+Na]-

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

36/37/38-22-40

safety instructions：

22-24/25-37/39-26-36

RTECS Number：

UP0791000

Marks：

Hazard note：

Harmful

Stability/Shelf Life：

Stable under normal temperatures and pressures.

Precautionary statement(s)：

P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501

Hazard Statements：

H315

GHS Classification：

|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 11 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH Entry Terms：

Hypoxanthine

Hypoxanthine Use and Manufacturing

Methods of Manufacturing

Ethyl cyanoacetate, sodium ethoxide, and thiourea are cyclized to obtain 2-mercapto-4-amino-6-hydroxypyrimidine, which is then nitrosated, reduced, eliminated, and cyclized to produce 6-hydroxypurine.

Uses

A naturally occurring purine derivative. Pharmaceuticals, Intermediates & Fine Chemicals

Manufacturing Info：

6H-Purin-6-one, 1,9-dihydro-: ACTIVE

Computed Properties

Molecular Weight:136.11
XLogP3:-0.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Exact Mass:136.03851076
Monoisotopic Mass:136.03851076
Topological Polar Surface Area:70.1
Heavy Atom Count:10
Complexity:190
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Ethyl cyanoacetate

Ammonium acetate

Drug Function and Efficacy

Hypoxanthine is an important substance involved in human life activities. It can improve the body's material metabolism and energy metabolism, accelerate the repair of damaged tissues, and promote the restoration of normal physiological functions of pathological cells and hypoxic tissues. Hypoxanthine, in combination with small molecule peptides and amino acids, can promote the body's metabolism.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Compound brain peptide ganglioside injection
Ingredients	This product is a compound preparation, a sterile aqueous solution made by mixing healthy rabbit muscle extract and pig brain extract. Its main components are polypeptides, various gangliosides, hypoxanthine, etc. Each 1ml contains 3.2mg polypeptide, 50μg ganglioside (calculated as sialic acid), and 0.125mg hypoxanthine. Excipients: water for injection.
Indication	It should not be used together with amino acid infusion.
Specifications	2 ml
Manufacturer	Samira Pharmaceutical Group Company Limited

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Guide of Hypoxanthine

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Material
Drug Function and Efficacy
Related Drugs
Recommended Suppliers
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Hypoxanthine

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