9-Fluorenylmethyl chloroformate
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9-Fluorenylmethyl chloroformate
structure -
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CAS No:
28920-43-6
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Formula:
C15H11ClO2
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Chemical Name:
9-Fluorenylmethyl chloroformate
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Synonyms:
Carbonochloridic acid,9H-fluoren-9-ylmethyl ester;Formic acid,chloro-,fluoren-9-ylmethyl ester;Fluorene-9-methanol,chloroformate;9-Fluorenylmethoxycarbonyl chloride;9-Fluorenylmethyl chloroformate;AminoTag;9-Fluorenylmethyl chlorocarbonate;9H-Fluoren-9-ylmethyl chloroformate;FMOC chloride;Fluorenylmethyl chloroformate;FmocCl;(9H-Fluoren-9-ylmethoxy)carbonyl chloride;9H-Fluoren-9-ylmethyl carbonochloridate;Chloroformic acid 9-fluorenylmethyl ester;86088-58-6;1489258-40-3
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CAS No:
9-Fluorenylmethyl chloroformate Basic Attributes
258.7
258.70
2279177
249-313-6
9PLB0BTT90
DTXSID10183116
29159020
Characteristics
26.3
4.3
White to very pale yellow Crystalline Powder
1.3±0.1 g/cm3
62-63 °C
393.9ºC at 760 mmHg
143.6±11.4 °C
1.612
dioxane: 0.1 g/mL, clear, colorless
2-8°C
2.06E-06mmHg at 25°C
Safety Information
II
6.1
UN 3261 8/PG 2
3
34-20/21/22
26-36/37/39-45-27
LQ6250000
C,T
Stable under normal temperatures and pressures.
P280-P305 + P351 + P338-P310
H314
|Danger|H302 (16.88%): Harmful if swallowed [Warning Acute toxicity, oral]|P260, P261, P264, P270, P271, P280, P301+P312, P301+P330+P331, P303+P361+P353, P304+P312, P304+P340, P305+P351+P338, P310, P312, P321, P330, P363, P405, and P501|Aggregated GHS information provided by 77 companies from 13 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Drug Information
Substances used for the detection, identification, analysis, etc. of chemical, biological, or pathologic processes or conditions. Indicators are substances that change in physical appearance, e.g., color, at or approaching the endpoint of a chemical titration, e.g., on the passage between acidity and alkalinity. Reagents are substances used for the detection or determination of another substance by chemical or microscopical means, especially analysis. Types of reagents are precipitants, solvents, oxidizers, reducers, fluxes, and colorimetric reagents. (From Grant and Hackh's Chemical Dictionary, 5th ed, p301, p499) (See all compounds classified as Indicators and Reagents.)
1-(9-fluorenyl)methyl chloroformate
9-Fluorenylmethyl chloroformate Use and Manufacturing
With stirring, 12.8g of 9-fluorenyl methanol was slowly added dropwise to the cooled phosgene-dichloromethane solution (7.12g of phosgene dissolved in 75ml of dichloromethane), and the reaction was allowed to stand for 4h after 1h. The solvent and excess phosgene were distilled off under reduced pressure to obtain 16 g of crude product. After recrystallization from ether, 14.5g of finished product was obtained with a yield of 86%.
Reagent for the introduction of Fmoc-amino-protecting group, which is stable towards acids but is readily cleaved under mildly basic non-hydrolytic conditions.
Computed Properties
Molecular Weight:258.70
XLogP3:4.3
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:258.0447573
Monoisotopic Mass:258.0447573
Topological Polar Surface Area:26.3
Heavy Atom Count:18
Complexity:296
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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