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(-)-Tetrahydrocolumbamine

(-)-Tetrahydrocolumbamine structure

CAS No:
483-34-1
Formula:
C20H23NO4
Chemical Name:
(-)-Tetrahydrocolumbamine
Synonyms:
6H-Dibenzo[a,g]quinolizin-2-ol,5,8,13,13a-tetrahydro-3,9,10-trimethoxy-,(13aS)-;13aα-Berbin-2-ol,3,9,10-trimethoxy-;6H-Dibenzo[a,g]quinolizin-2-ol,5,8,13,13a-tetrahydro-3,9,10-trimethoxy-,(S)-;Isocorypalmine;Columbamine,tetrahydro-;(13aS)-5,8,13,13a-Tetrahydro-3,9,10-trimethoxy-6H-dibenzo[a,g]quinolizin-2-ol;Isocorypalmine,(-)-;(-)-Isocorypalmine;Columbamine,tetrahydro-,(-)-;l-Isocorypalmine;(-)-Tetrahydrocolumbamine;l-Tetrahydrocolumbamine;Alkaloid L,from Corydalis;O10-Methylstepholidine;Corydalis L;Tetrahydrocolumbamine;(S)-Tetrahydrocolumbamine;2-O-Desmethyl-L-THP;(13AS)-3,9,10-trimethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinolin-2-ol;483-33-0;1356-03-2;20504-94-3
Categories:
Organic Chemistry > Heterocyclic Ring

Description

(-)-Isocorypalmine, an alkaloid isolated from Corydalis chaerophylla, possesses antifungal activity[1].

(S)-tetrahydrocolumbamine is a berberine alkaloid consisting of columbamine having four extra hydrogens at positions 5, 8, 13 and 13a and (S)-configuration. It is a berberine alkaloid and an organic heterotetracyclic compound. It derives from a columbamine.

(-)-Tetrahydrocolumbamine Basic Attributes

Molecular Weight：

341.401

Exact Mass：

341.40

UNII：

MX470OL19D

HScode：

2933990090

Characteristics

PSA：

51.16000

XLogP3：

2.93

Density：

1.3±0.1 g/cm3

Melting Point：

144 °C

Boiling Point：

501.2±50.0 °C at 760 mmHg

Flash Point：

256.9±30.1 °C

Refractive Index：

1.640

Vapor Pressure：

1.14E-10mmHg at 25°C

Toxicity：

LD50 intravenous in mouse: 133mg/kg

Drug Information

MeSH Entry Terms：

tetrahydro-columbamine

(-)-Tetrahydrocolumbamine Use and Manufacturing

A metabolite of the isoquinoline alkaloid biosynthesis pathway.

Computed Properties

Molecular Weight:341.4
XLogP3:2.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:341.16270821
Monoisotopic Mass:341.16270821
Topological Polar Surface Area:51.2
Heavy Atom Count:25
Complexity:461
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of (-)-Tetrahydrocolumbamine

Shaanxi Dideu Medichem Co. Ltd Contact Supplier

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(S)-Isocorypalmine

CAS No.: 483-34-1

Grade: Industrial Grade

Content: 99%

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Guide of (-)-Tetrahydrocolumbamine

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Characteristics
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(-)-Tetrahydrocolumbamine

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