 Home > Encyclopedia > Sitagliptin phosphate

Sitagliptin phosphate

Sitagliptin phosphate structure

CAS No:
654671-78-0
Formula:
C16H15F6N5O.H3O4P
Chemical Name:
Sitagliptin phosphate
Synonyms:
1-Butanone,3-amino-1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-,(3R)-,phosphate (1:1);1,2,4-Triazolo[4,3-a]pyrazine,7-[(3R)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-,phosphate (1:1);MK 0431;MK 431;Sitagliptin phosphate;Januvia;Glactiv;790712-60-6
Categories:
Pharmaceutical Intermediates > Heterocyclic Compound

Description

White Solid

A pyrazine-derived DIPEPTIDYL-PEPTIDASE IV INHIBITOR and HYPOGLYCEMIC AGENT that increases the levels of the INCRETIN hormones GLUCAGON-LIKE PEPTIDE-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). It is used in the treatment of TYPE 2 DIABETES.

Sitagliptin phosphate Basic Attributes

Molecular Weight：

505.31

Exact Mass：

505.095

UNII：

494P4635I6

DSSTox ID：

DTXSID10215789

ATC Code：

A10BH01

HScode：

2933990090

Characteristics

PSA：

155

XLogP3：

1.72610

Appearance：

white solid

Melting Point：

215-217 °C

Boiling Point：

529.9ºC at 760 mmHg

Flash Point：

274.3ºC

Drug Information

Drug Indication：

For adult patients with type-2 diabetes mellitus, Januvia is indicated to improve glycaemic control:as monotherapy:in patients inadequately controlled by diet and exercise alone and for whom metformin is inappropriate due to contraindications or intolerance;as dual oral therapy in combination with:metformin when diet and exercise plus metformin alone do not provide adequate glycaemic control;a sulphonylurea when diet and exercise plus maximal tolerated dose of a sulphonylurea alone do not provide adequate glycaemic control and when metformin is inappropriate due to contraindications or intolerance;a peroxisome-proliferator-activated-receptor-gamma (PPARγ) agonist (i.e. a thiazolidinedione) when use of a PPARγ agonist is appropriate and when diet and exercise plus the PPARγ agonist alone do not provide adequate glycaemic control;a PPARγ agonist (i.e. a thiazolidinedione) when use of a PPARγ agonist is appropriate and when diet and exercise plus the PPARγ agonist alone do not provide adequate glycaemic control;as triple oral therapy in combination with:a sulphonylurea and metformin when diet and exercise plus dual therapy with these medicinal products do not provide adequate glycaemic control;a PPARγ agonist and metformin when use of a PPARγ agonist is appropriate and when diet and exercise plus dual therapy with these medicinal products do not provide adequate glycaemic control.Januvia is also indicated as add-on to insulin (with or without metformin) when diet and exercise plus stable dose of insulin do not provide adequate glycaemic control.

MeSH：

Compounds that suppress the degradation of INCRETINS by blocking the action of DIPEPTIDYL-PEPTIDASE IV. This helps to correct the defective INSULIN and GLUCAGON secretion characteristic of TYPE 2 DIABETES MELLITUS by stimulating insulin secretion and suppressing glucagon release. (See all compounds classified as Dipeptidyl-Peptidase IV Inhibitors.)|Substances which lower blood glucose levels. (See all compounds classified as Hypoglycemic Agents.)|Peptides which stimulate INSULIN release from the PANCREATIC BETA CELLS following oral nutrient ingestion, or postprandially. (See all compounds classified as Incretins.)

MeSH Entry Terms：

0431, MK

Sitagliptin phosphate Use and Manufacturing

Uses

A trizolopyrazine dipeptidyl peptidase IV inhibitor. It has recently been approved for the therapy of type II diabetes. Sitagliptin is a trizolopyrazine dipeptidyl peptidase IV inhibitor. Sitagliptin has recently been approved for the therapy of type II diabetes.

Use Classification：

Human drugs -> Januvia -> EMA Drug Category|Drugs used in diabetes -> Human pharmacotherapeutic group|Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:505.31
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:14
Rotatable Bond Count:4
Exact Mass:505.09497466
Monoisotopic Mass:505.09497466
Topological Polar Surface Area:155
Heavy Atom Count:33
Complexity:616
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Recommended Suppliers of Sitagliptin phosphate

Hainan Flying International Trade Co., L Contact Supplier

CN
3 YRS

Business licensed

Trader Supplier of vitamin

99% High Value Purity Chemicals API Sitagliptin Phosphate powder 654671-78-0

CAS No.: 654671-78-0

Grade: Food grade

Content: 99%

Inquiry
Xi'an Honest BioEngr Co.,Ltd. Contact Supplier

CN
3 YRS

Business licensed

Trader Supplier of Estradiol,Progesterone,GS441524,4-Butylresorcinol,DeoxyArbutin,Coenzyme Q10,Piracetam,Pregabalin,Ketoprofen,omeprazole,Fullerene C60,Melatonin,Nicotinamide riboside chloride,lactoferrin,Tylosin tartrate,Gentamycin Sulfate,Levamisole HCl,Praziquantel,Ivermectin,GA3,Pepsin,MT2,5 amino 1MQ,selank,semax

99% pure high quality raw material Sitagliptin Phosphate CAS 654671-78-0 with Best Price

CAS No.: 654671-78-0

Grade: Pharmaceutical Grade

Content: 99%

Inquiry
Henan Lihao Chem Plant Limited Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of PVC resin,pvc paste resin,melamine

Sitagliptin Phosphate 99% see COA Kanbei kanbei

CAS No.: 654671-78-0

Grade: Industrial Grade

Content: 99%

Inquiry
chemtour Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of amino acid derivatives,pharmaceutical intermediates,oligonucleotide reagent

Sitagliptin phosphate-EP

CAS No.: 654671-78-0

Grade: Pharmaceutical Grade

Content: 99%

Inquiry
Beton Nutrition Corporation Contact Supplier

CN
3 YRS

Business licensed

Trader Supplier of olive leaf extract,ginger extract,ginseng extract,Black garlic extract,Echinacea purpurea extract,Horse Chestnut Extract,Pueraria extract,Andrographis Extract,citrus aurantium extract,quercetin,Rutin,chlorogenic acid,Curcumin,Apigenin

Sitagliptin phosphate CAS :654671-78-0 with high purity

CAS No.: 654671-78-0

Grade: Pharmaceutical Grade

Content: 99.9%

Inquiry