Trospium chloride
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Trospium chloride
structure -
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CAS No:
10405-02-4
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Formula:
C25H30NO3.Cl
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Chemical Name:
Trospium chloride
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Synonyms:
Spiro[8-azoniabicyclo[3.2.1]octane-8,1′-pyrrolidinium],3-[(2-hydroxy-2,2-diphenylacetyl)oxy]-,chloride (1:1),(1α,3β,5α)-;Spiro[1αH,5αH-nortropane-8,1′-pyrrolidinium],3α-hydroxy-,chloride,benzilate;Spiro[8-azoniabicyclo[3.2.1]octane-8,1′-pyrrolidinium],3-[(hydroxydiphenylacetyl)oxy]-,chloride,(1α,3β,5α)-;Benzilic acid,ester with 3α-hydroxyspiro[1αH,5αH-nortropane-8,1′-pyrrolidinium] chloride;Azoniaspiro(3α-benziloyloxynortropane-8,1′-pyrrolidine) chloride;Trospium chloride;Azoniaspiro compound XVII;As XVII;Keptan;Spasmex;Spasmo 3;Spasmo-lyt;Relaspium;Sanctura;Sanctura XR;Trozyd;TAR 302-5018;1001323-19-8
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CAS No:
Description
White to Off-White Crystalline SolidTrosoium chloride, 3α-benziloyloxynortropane-8-spiro-1' -pyrrolidinium chloride, (Sanctura)was available in Europe for almost 20 years before gainingapproval in the United States in May 2004. Much likeoxybutynin, it too is a competitive antagonist for muscarinicreceptors and is used to manage overactive bladder. Thequaternary amine reduces the likelihood that this agent willcross the blood-brain barrier. In addition, it has a limitedmetabolic profile, largely
Characteristics
46.5
0.73250
white to off-white powder
255-257 °C
Very soluble in water, freely soluble in methanol, practically insoluble in methylene chloride.
-20°C Freezer
Soly in water: ~1 g/2 ml. LD50 in mice (mg/kg): 12.3 i.v. (Antweiler)
Trospium chloride Use and Manufacturing
Labeled Trospium, intended for use as an internal standard for the quantification of Trospium by GC- or LC-mass spectrometry.
Drug Function and Efficacy
Extract from the above information
Registered Holders
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MACLEODS PHARMACEUTICALS LTD
Active
India
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SIEGFRIED EVIONNAZ SA
Active
France
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PROCOS S.P.A.
Active
Italy
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