Ethyl 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate
-
![Ethyl 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate structure](https://file.echemi.com/fileManage/upload/canonicalSmiles/20220812/96727fd202da4fab9bd62321e8552279.png "Ethyl 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate")
Ethyl 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate
structure -
-
CAS No:
503614-91-3
-
Formula:
C27H28N4O5
-
Chemical Name:
Ethyl 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate
-
Synonyms:
1H-Pyrazolo[3,4-c]pyridine-3-carboxylic acid,4,5,6,7-tetrahydro-1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxo-1-piperidinyl)phenyl]-,ethyl ester;1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester;Ethyl 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate;Apixaban ethyl ester
- Categories:
-
CAS No:
Ethyl 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate Basic Attributes
488.54
488.54
700-890-7
DTXSID50623728
Safety Information
H412 (100%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]|P273, and P501|Aggregated GHS information provided by 3 companies from 1 notifications to the ECHA C&L Inventory.
Ethyl 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate Use and Manufacturing
Dissolve 15.7 g of apixaban intermediate IV in 160 mL of anhydrous dichloromethane.4.0 g of ground sodium hydroxide was added, and 8.4 g of 5-bromovaleryl chloride was added dropwise. After the addition was completed, 4.0 g of finely ground sodium hydroxide was added and the mixture was stirred at 30 to 35 C for 6 hours.Quench with water and extract with dichloromethane.The organic phase is used as a 10% sodium bicarbonate aqueous solution (the mass percentage refers to the mass of sodium bicarbonate as a percentage of the total mass of the aqueous sodium bicarbonate solution) and the mass percentage isA 15% saline wash (the mass percentage referred to the percentage of sodium chloride in the total mass of the saline solution) was dried over anhydrous sodium sulfate.It was filtered and concentrated in vacuo (25C-45C, -0.075 MPa--0.09 MPa). Ethyl acetate (96 mL) was added to the residue. After heating to 75C, the solution was slowly cooled to 15C-20C and stirred for 1 hour.Filtration, washing with ethyl acetate, suction drying, vacuum drying at -0.01 MPa to -0.1 MPa, 45C to 55C for 8 hours to 12 hours, yielded 9.52 g of apixaban intermediate V, yield 50.4%.Compound VII (20 g, 0.049 mol) was added to a 250 mL three-necked flask, Dry tetrahydrofuran (200 mL), Triethylamine (10.2 mL, 0.073 mol), Cooling to 0 C, 5-chlorovaleryl chloride (9.4 mL, 0.073 mol) was added in portions, After adding 60C reaction 2h.Then cooled to -10 C, sodium tert-butoxide (12.1 g, 0.16 mol) was added in portions, Join the process of controlling the temperature below 0C , After the addition was warmed to 50 C reaction 4h.The tetrahydrofuran was distilled off under reduced pressure, To the residue was added saturated sodium carbonate aqueous 200mL slurry, A solid precipitation, Filter products, Yellow solid, 9.45 g, m.p. 151-154 C, Yield 39.4%.
Computed Properties
Molecular Weight:488.5
XLogP3:3.6
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:7
Exact Mass:488.20597001
Monoisotopic Mass:488.20597001
Topological Polar Surface Area:94
Heavy Atom Count:36
Complexity:808
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Recommended Suppliers of Ethyl 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate
-
![Hongkong, China]()
HK
2 YRS
Business licensedTrader Supplier of Weight Loss Peptide,Reta,Tirz,Sema,5 Amino 1mq,Cosmetic raw material,API,SLU-PP-332,Orforglipron,Pharmaceutical intermediates,Aniracetam,Paraxanthine,AF710B,Clascoterone,TAK-653,PRL-8-53InquiryCAS No.: 503614-91-3Grade: Pharmaceutical GradeContent: 99% -
![Hongkong, China]()
HK
1 YR
Business licensedTrader Supplier of pharmaceutical intermediates,chemicalInquiryCAS No.: 503614-91-3Grade: pharmaceutical gradeContent: 99% -
![Taiwan, China]()
TW
5 YRS
Business licensed Certified factoryManufactory Supplier of API,SPECIALTY CHECMICALS,API INTERMEDIATEInquiryCAS No.: 503614-91-3Grade: Pharmaceutical GradeContent: 99.6% -
![China]()
CN
5 YRS
Business licensedTrader Supplier of PVC resin,pvc paste resin,melamineInquiryCAS No.: 503614-91-3Grade: Industrial GradeContent: 99% -
![China]()
CN
3 YRS
Business licensedTrader Supplier of CHEMICALS,REAGENTSInquiryCAS No.: 503614-91-3Grade: Pharmaceutical GradeContent: 99%
Latest News on Ethyl 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate
Learn More Other Chemicals
-
Cyclohexanecarboxylic acid, 1,3,4,5-tetrahydroxy-, ethyl ester, (1alpha,3R,4alpha,5R)- (9CI)
463325-95-3
-
Cyclopropanecarboxylic acid, 1-formyl-2-methyl-, ethyl ester (9CI)
260261-27-6
-
3-CYCLOPROPYL-2-METHYL-3-OXO-PROPIONIC ACID ETHYL ESTER
21741-37-7
-
Cyclopropanecarboxylic acid, 1-amino-2-phenyl-, ethyl ester, (1R,2R)-rel- (9CI) Formula
669058-57-5
-
Cyclopropanecarboxylic acid, 1-amino-2-ethenyl-, ethyl ester, (1R,2S)-rel- (9CI) Formula
213316-32-6
-
Cyclopropanecarboxylic acid, 1-amino-2-ethenyl-, ethyl ester, hydrochloride (9CI) Formula
681807-60-3
-
3-Cyclopentene-1-carboxylic acid, 1-(chlorocarbonyl)-, ethyl ester (9CI) Structure
76910-09-3
-
Cyclopropanecarboxylic acid, 2-propyl-, ethyl ester, (1R,2S)- (9CI) Structure
492468-18-5
-
What is Cyclopentanecarboxylic acid, 2-(formylhydrazono)-, ethyl ester, (Z)- (9CI)
163352-99-6
-
What is 2-[(2,6-Dichlorophenyl)sulfonyl]acetic acid ethyl ester
1154228-17-7
Ethyl 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate
SDSRequest for Quotation