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2,2-Dimethylthiazolidine

2,2-Dimethylthiazolidine structure

CAS No:
19351-18-9
Formula:
C5H11NS
Chemical Name:
2,2-Dimethylthiazolidine
Synonyms:
Thiazolidine,2,2-dimethyl-;2,2-Dimethylthiazolidine;2,2-Dimethyl-1,3-thiazolidine;2,2-Dimethyltetrahydrothiazole
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

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2,2-Dimethylthiazolidine Basic Attributes

Molecular Weight：

117.21

Exact Mass：

117.21

EC Number：

242-980-4

DSSTox ID：

DTXSID3051832

HScode：

2934999090

Characteristics

PSA：

37.3

XLogP3：

0.9

Appearance：

Colorless liquid

Density：

1.0±0.1 g/cm3

Boiling Point：

61 °C @ Press: 15 Torr

Flash Point：

55°C

Refractive Index：

1.477

Vapor Pressure：

1.5mmHg at 25°C

Safety Information

Hazard category：

Transport codes：

1993

hazard class code：

10-36/37/38-25

safety instructions：

16-26-36/37/39-45

RTECS Number：

XJ5565700

Marks：

Precautionary statement(s)：

P210, P233, P234, P240, P241, P242, P243, P264, P270, P280, P301+P312, P302+P352, P303+P361+P353, P305+P351+P338, P312, P321, P322, P330, P332+P313, P337+P313, P361, P362, P363, P370+P378, P390, P403+P235, P404, P405, P501

Hazard Statements：

H226

GHS Classification：

|Danger|H226 (82.54%): Flammable liquid and vapor [Warning Flammable liquids]|P210, P233, P234, P240, P241, P242, P243, P264, P270, P280, P301+P312, P302+P352, P303+P361+P353, P305+P351+P338, P312, P321, P322, P330, P332+P313, P337+P313, P361, P362, P363, P370+P378, P390, P403+P235, P404, P405, and P501|Aggregated GHS information provided by 63 companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH Entry Terms：

2,2-dimethylthiazolidine

2,2-Dimethylthiazolidine Use and Manufacturing

Methods of Manufacturing

A process for the preparation of 2, 2-dimethyltetrahydrothiazole comprising the steps of:1) Refining: 450 kg of 95percent cysteamine hydrochloride and 450 kg of ethanol were injected at a 1: 1 ratioInto the reactor, cooling crystallization, rejection filter solid phase for pure cysteamine hydrochloride 405kg, obtainedLiquid phase distillation recovery of ethanol 425kg;2) Neutralization: 1350 kg of cyclohexane, 405 kg of pure cysteamine hydrochloride and 430 kg of acetoneInto the reactor, adding liquid caustic soda 405kg to neutral; which liquid alkali accounted for in water285 kg, NaOH 120 kg;3) azeotropic dehydration: the reactor temperature rose to 78 , reflux azeotropic dehydration, anti-heatShould be 10 hours;4) filtration: the end of the reaction, cooling to 33 , 182kg filter salt;5) Distillation: The filtrate was distilled to recover 1225 kg of cyclohexane and 230 kg of acetone;Acetone solvent distillation are carried out in the reactor; distillation and condensation are water-cooled plus frozen saltWater freezing;6) Rectification: distillation of the remaining crude oil distillation column distillation products 2, 2 - dimethyl tetrahydrothiophene348 kg.

Manufacturing Info：

Thiazolidine, 2,2-dimethyl-: ACTIVE

Computed Properties

Molecular Weight:117.22
XLogP3:0.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Exact Mass:117.06122053
Monoisotopic Mass:117.06122053
Topological Polar Surface Area:37.3
Heavy Atom Count:7
Complexity:70.5
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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2,2-Dimethylthiazolidine

CAS No.: 19351-18-9

Grade: Industrial Grade

Content: 99%

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