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Oxidized glutathione

Oxidized glutathione structure

CAS No:
27025-41-8
Formula:
C20H32N6O12S2
Chemical Name:
Oxidized glutathione
Synonyms:
Glycine,L-γ-glutamyl-L-cysteinyl-,bimol. (2→2′)-disulfide;Glutamine,N,N′-[dithiobis[1-[(carboxymethyl)carbamoyl]ethylene]]di-,L-;Glutamine,N,N′-[dithiobis[1-[(carboxymethyl)carbamoyl]ethylene]]di-;Glutathione-SSG;GSSG;Oxidized glutathione;Glutathione,disulfide;Glutathione,oxidized;Glutathione-S-S-glutathione;Oxidized L-glutathione;Glutathione disulphide;Sleep-promoting factor B;Oxiglutatione;Selenoglutathione;121-24-4;10421-65-5;87140-29-2;97908-42-4;371915-35-4;475558-84-0;1254121-37-3;1260488-58-1;2394733-76-5
Categories:
Cosmetic Ingredient > Skin Conditioning

Description

Glutathione oxidized is produced by the oxidation of glutathione which is a major intracellular antioxidant and detoxifying agent.

Solid

Glutathione disulfide is an organic disulfide and a glutathione derivative. It has a role as an Escherichia coli metabolite and a mouse metabolite. It is a conjugate acid of a glutathione disulfide(2-).|A GLUTATHIONE dimer formed by a disulfide bond between the cysteine sulfhydryl side chains during the course of being oxidized.|Oxiglutatione is the oxidized disulfide form of glutathione (GSH) with potential protective activity. Glutathione disulfide (GSSG) is reduced by glutathione reductase to GSH. GSSG and GSH together play important roles in numerous redox reactions, such as those involved in the detoxification of harmful substances and free radicals, and in reactions preventing oxidative damage in erythrocytes. Upon ocular administration in irrigation solution, glutathione disulfide may exert a beneficial effect on the intracellular redox state of glutathione, thereby protecting the integrity and barrier function of the corneal endothelial cells.

Oxidized glutathione Basic Attributes

Molecular Weight：

612.63

Exact Mass：

612.151978

EC Number：

248-170-7

UNII：

ULW86O013H

DSSTox ID：

DTXSID5048972

NCI Thesaurus Code：

C62624

HScode：

29309090

Characteristics

PSA：

368

XLogP3：

-9.1

Appearance：

Solid

Density：

1.7±0.1 g/cm3

Melting Point：

170-172 °C

Boiling Point：

1196.5°C at 760 mmHg

Flash Point：

544.3±37.1 °C

Refractive Index：

1.677

Water Solubility：

soluble

Storage Conditions：

2-8ºC

Vapor Pressure：

0mmHg at 25°C

Collision Cross Section：

224.7 Å² [M+H]+ [CCS Type: DT, Method: single field calibrated with Agilent tune mix (Agilent)]|227 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine]

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

R36/37/38

safety instructions：

S26-S36-S24/25

RTECS Number：

MC0556500

Marks：

Xi: Irritant;

Stability/Shelf Life：

Stable. Incompatible with strong oxidizing agents.

Precautionary statement(s)：

P264, P280, P302+P352, P305+P351+P338, P321, P332+P313, P337+P313, P362

Hazard Statements：

H315

GHS Classification：

|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 8 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH Entry Terms：

Disulfide, Glutathione

Oxidized glutathione Use and Manufacturing

Uses

L(-)-Glutathione is a biomarker for fatty liver disease. S,S'-Ethylenebis(glutathione) is a haloethane-glutathione conjugate formed via GSH transferases. S,S'-Ethylenebis(glutathione) formation is used to study the polymorphism in glutathione conjugation ac tivity of human erythrocytes towards ethylene dibromide.

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:612.6
XLogP3:-9.1
Hydrogen Bond Donor Count:10
Hydrogen Bond Acceptor Count:16
Rotatable Bond Count:21
Exact Mass:612.15196282
Monoisotopic Mass:612.15196282
Topological Polar Surface Area:368
Heavy Atom Count:40
Complexity:879
Defined Atom Stereocenter Count:4
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Guide of Oxidized glutathione

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Recommended Suppliers
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Oxidized glutathione

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