Clodronate sodium
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Clodronate sodium
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CAS No:
22560-50-5
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Formula:
CH4Cl2O6P2.2Na
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Chemical Name:
Clodronate sodium
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Synonyms:
Phosphonic acid,P,P′-(dichloromethylene)bis-,sodium salt (1:2);Phosphonic acid,(dichloromethylene)di-,disodium salt;Phosphonic acid,(dichloromethylene)bis-,disodium salt;Sodium (dichloromethylene)diphosphonate;Disodium (dichloromethane)diphosphonate;Disodium (dichloromethylene)diphosphonate;(Dichloromethylene)diphosphonate disodium;Dichloromethylenediphosphonic acid disodium salt;Sodium clodronate;BM 06011;Clodronate sodium;Disodium clodronate;Lodronate;Ostac;Dichloromethylenebisphosphonic acid disodium salt;Diphosfonal;Clodronate disodium salt;Bonefos;Clasteon;Mebonat;DClMDP;Difoafonal;Clodronic acid disodium salt;Loron;Ossiten;Disodium (dichloromethylene)bisphosphonate;Clodronate disodium
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CAS No:
Description
Clodronic acid (Clodronate) disodium salt, a first-generation bisphosphonate, is orally active osteoclastic bone resorption inhibitor. Clodronic acid disodium salt can be used in high bone turnover states, Paget’s disease and osteolytic bone metastases[1][2][3].
Clodronic acid disodium salt is the disodium salt of clodronic acid. It inhibits bone resorption and soft tissue calcification, and is used (generally as the tetrahydrate) as an adjunct in the treatment of severe hypercalcaemia associated with malignancy, and in the management of osteolytic lesions and bone pain associated with skeletal metastases. It has a role as a bone density conservation agent. It is an organic sodium salt and a one-carbon compound. It contains a clondronate(2-).|A diphosphonate which affects calcium metabolism. It inhibits bone resorption and soft tissue calcification.
Clodronate sodium Basic Attributes
288.86
287.849915
245-078-9
Y05R4GCQ1H
DTXSID3045225|DTXSID40237035
2931900090
Safety Information
NONH for all modes of transport
3
SZ7640700
|Warning|H373 (100%): Causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]|P260, P273, P314, P391, and P501|Aggregated GHS information provided by 27 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H302 (80%): Harmful if swallowed [Warning Acute toxicity, oral]|P201, P202, P261, P264, P270, P271, P273, P281, P301+P312, P304+P312, P304+P340, P308+P313, P312, P330, P391, P405, and P501|Aggregated GHS information provided by 5 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Drug Information
Agents that inhibit BONE RESORPTION and/or favor BONE MINERALIZATION and BONE REGENERATION. They are used to heal BONE FRACTURES and to treat METABOLIC BONE DISEASES such as OSTEOPOROSIS. (See all compounds classified as Bone Density Conservation Agents.)
Acid, Clodronic
Clodronate sodium Use and Manufacturing
A bisphosphonate antiresorptive agent; bone resorption inhibitor.
Computed Properties
Molecular Weight:288.85
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:2
Exact Mass:287.8499057
Monoisotopic Mass:287.8499057
Topological Polar Surface Area:121
Heavy Atom Count:13
Complexity:206
Covalently-Bonded Unit Count:3
Compound Is Canonicalized:Yes
Drug Function and Efficacy
This product is a bone metabolism regulator that can enter the hydroxyapatite crystals in the bone matrix. When osteoclasts dissolve the crystals, the drug is released, which can inhibit the activity of osteoclasts and indirectly inhibit bone resorption through osteoblasts.
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