 Home > Encyclopedia > Tesmilifene

Tesmilifene

Tesmilifene structure

CAS No:
98774-23-3
Formula:
C19H25NO
Chemical Name:
Tesmilifene
Synonyms:
Ethanamine,N,N-diethyl-2-[4-(phenylmethyl)phenoxy]-;Triethylamine,2-(α-phenyl-p-tolyloxy)-;N,N-Diethyl-2-[4-(phenylmethyl)phenoxy]ethanamine;N,N-Diethyl-2-(p-benzylphenoxy)ethylamine;DPPE;Tesmilifene;2-(4-Benzylphenoxy)-N,N-diethylethanamine
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

N,N-diethyl-2-[4-(phenylmethyl)phenoxy]ethanamine is a diarylmethane.|Tesmilifene is a novel potentiator of chemotherapy which, when added to doxorubicin, achieved an unexpected and very large survival advantage over doxorubicin alone in a randomized trial in advanced breast cancer.

Tesmilifene Basic Attributes

Molecular Weight：

283.415

Exact Mass：

283.41

UNII：

I43T3ID6G2

DSSTox ID：

DTXSID1045661

Characteristics

PSA：

12.5

XLogP3：

5.04

Appearance：

Transparent, colorless liquid

Density：

1.0±0.1 g/cm3

Boiling Point：

397.0±30.0 °C at 760 mmHg

Flash Point：

116.8±26.9 °C

Refractive Index：

1.543

Drug Information

Drug Indication：

Intended for the treatment of various forms of cancer.

MeSH：

Drugs that bind to but do not activate histamine receptors, thereby blocking the actions of histamine or histamine agonists. Classical antihistaminics block the histamine H1 receptors only. (See all compounds classified as Histamine Antagonists.)|Drugs or agents which antagonize or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system. (See all compounds classified as Platelet Aggregation Inhibitors.)

Metabolism/Metabolites：

Hepatic

Mechanism of Action：

Although the exact mechanism of action is not known, one study (PMID: 16413681) proposes that tesmilifene may be an activating p-gp substrate, which enables the p-gp pump to extrude typical p-gp substrates (such as anthracyclines or taxanes) more efficiently. This process consumes ATP, since the p-gp is absolutely, and highly dependent on ATP hydrolysis. The mechanism of cell death is likely to result not from the presence of chemotherapy inside the cell (in fact the chemotherapy is extruded) but, directly or indirectly, from the enhanced consumption of ATP. The ATP may be consumed below a threshold necessary for survival, or, (more likely) the enhanced ATP production required to maintain ATP levels may result in the generation of reactive oxygen species (ROS) to an extent that overwhelms the cell’s ability to inactivate them. The result would be additional cell death, but only in the mdr+ population. The doxorubicin would continue to act on the drug sensitive remainder of the cell population, but without the help of tesmilifene.

MeSH Entry Terms：

(2-(4-benzylphenoxy)ethyl)diethylamine

Computed Properties

Molecular Weight:283.4
XLogP3:4.6
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:8
Exact Mass:283.193614421
Monoisotopic Mass:283.193614421
Topological Polar Surface Area:12.5
Heavy Atom Count:21
Complexity:250
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of Tesmilifene

LEADER BIOCHEMICAL GROUP Contact Supplier

CN
8 YRS

Business licensed Certified factory

Manufactory Supplier of Biochemicals Ingredients,Vitamin Amino Acid Ingredients,Cosmestic Ingredients,Pharma Chemicals,Organic Fine Chemicals,Food Nutrient Ingredients,Natural Plant Ingredients,APIS Intermidiates,Daily Chemicals,Agricultural Chemicals,Surfactant Chemicals,Ultraviolet Absorbents,Antioxidant Ingredients,Scientific Research Chemical,Flavors and Fragrances Chemicals

China Largest Manufacturer Supply High Purity Ponazuril CAS 98774-23-3

CAS No.: 98774-23-3

Grade: Pharmaceutical Grade

Content: 99%

Inquiry
Changzhou Xuanming Pharmaceutical Techno Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of Peptides,Chemicals,API,Additives

High Cost Performance Tesmilifene 98774-23-3

CAS No.: 98774-23-3

Grade: Pharmaceutical Grade

Content: 99%

Inquiry