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(-)-Bergenin

(-)-Bergenin structure

CAS No:
477-90-7
Formula:
C14H16O9
Chemical Name:
(-)-Bergenin
Synonyms:
Pyrano[3,2-c][2]benzopyran-6(2H)-one,3,4,4a,10b-tetrahydro-3,4,8,10-tetrahydroxy-2-(hydroxymethyl)-9-methoxy-,(2R,3S,4S,4aR,10bS)-;Bergenin;Pyrano[3,2-c][2]benzopyran-6(2H)-one,3,4,4a,10b-tetrahydro-3,4,8,10-tetrahydroxy-2-(hydroxymethyl)-9-methoxy-,[2R-(2α,3β,4α,4aα,10bβ)]-;α-Resorcylic acid,4-methoxy-2-[tetrahydro-3,4,5-trihydroxy-6-(hydroxymethyl)pyran-2-yl]-,δ-lactone;(2R,3S,4S,4aR,10bS)-3,4,4a,10b-Tetrahydro-3,4,8,10-tetrahydroxy-2-(hydroxymethyl)-9-methoxypyrano[3,2-c][2]benzopyran-6(2H)-one;Ai Cha Su;Corylopsin;Vakerin;Peltophorin;Cuscutin;Ardisic acid B;Bergenit;NSC 661749;(-)-Bergenin;Bergeninum;Bengenin;1391-25-9;12262-00-9;22550-81-8
Categories:
Cosmetic Ingredient > Skin Conditioning

Description

Bergenin, a polyphenol, is a potent antinarcotic agent with antioxidant action. IC50 value: < 2.5 μM (antiplasmodial) [3]Target:In vitro: The naloxone-precipitated withdrawal symptom (jumping frequency) was significantly ameliorated (50% of control group) by administration of bergenin (20 mg/kg) in morphine-treated mice. Furthermore, morphine-induced down-regulation of glutathione (GSH) contents was reversed by bergenin administration in the frontal cortex and liver [2].In vivo: Bergenin

Bergenin is a trihydroxybenzoic acid. It has a role as a metabolite.

(-)-Bergenin Basic Attributes

Molecular Weight：

328.27

Exact Mass：

328.27

EC Number：

1308068-626-2

UNII：

L84RBE4IDC

DSSTox ID：

DTXSID4048141

HScode：

29329990

Characteristics

PSA：

146

XLogP3：

-1

Appearance：

the loose white needle crystal powder or crystalline

Density：

1.6±0.1 g/cm3

Melting Point：

238 °C

Boiling Point：

658.9ºC at 760 mmHg

Flash Point：

250.7±25.0 °C

Refractive Index：

1.655

Storage Conditions：

-20°C

Vapor Pressure：

2.92E-18mmHg at 25°C

Specific rotation：

D18 -37.7° (c = 1.96 in ethanol); D24 -45.3° (c = 0.51 for anhydr in water)

Collision Cross Section：

168.3 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

36/37/38-20/21/22

safety instructions：

26-36

RTECS Number：

UQ0337200

Marks：

Xi,Xn

Precautionary statement(s)：

P261-P305 + P351 + P338

Hazard Statements：

H315-H319-H335

GHS Classification：

|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 39 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH Entry Terms：

bergenin

(-)-Bergenin Use and Manufacturing

Methods of Manufacturing

Take the crude powder of crude medicine (Astragalus or Iris) and dip it with 95% ethanol. The resulting ethanol solution is concentrated to recover ethanol. The concentrated solution is added with concentrated ammonia to pH 9-10 to precipitate the crude bergenin. The crude product is dissolved in ethanol, decolorized with activated carbon, and recrystallized to obtain the finished product of bergenin, calculated as crude drugs, with a yield of 1.5%.

Uses

A herbal remedy with antioxidant, antimicrobial and antiinflammatory properties.

Computed Properties

Molecular Weight:328.27
XLogP3:-1
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:2
Exact Mass:328.07943208
Monoisotopic Mass:328.07943208
Topological Polar Surface Area:146
Heavy Atom Count:23
Complexity:458
Defined Atom Stereocenter Count:5
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Extract from the above information

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Bergenin
Manufacturer	Yunnan Baiyao Group Dali Pharmaceutical Co., Ltd.

Compound Bergenia tablets
Ingredients	This product is a compound preparation, the components are: each tablet contains 125 mg of bergenin and 2 mg of chlorpheniramine maleate.
Indication	Not yet clear.
Specifications	Bergenin 0.125g, Chlorpheniramine Maleate 2mg

Compound Bergenia tablets
Ingredients	This product is a compound preparation, the components are: each tablet contains 125 mg of bergenin and 2 mg of chlorpheniramine maleate.
Indication	Not yet clear.
Specifications	Bergenin 0.125g, Chlorpheniramine Maleate 2mg
Manufacturer	Yunnan Mingjing Pharmaceutical Co., Ltd.

See More Related Drugs

Recommended Suppliers of (-)-Bergenin

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China Most Professional Factory Supply High Qulity Bengenin CAS 477-90-7

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Grade: Pharmaceutical Grade

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Factory 99% Bergenia Extract Powder Bergenin CAS 477-90-7

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Grade: Pharmaceutical grade

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Professional Plant Extract Manufacturer CAS 477-90-7 98% Bengenin

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Content: 0.00%

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Guide of (-)-Bergenin

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Drug Function and Efficacy
Related Drugs
Recommended Suppliers
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(-)-Bergenin

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