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Tildipirosin

Tildipirosin structure

CAS No:
328898-40-4
Formula:
C41H71N3O8
Chemical Name:
Tildipirosin
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

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Description

Tildipirosin, a long-acting macrolide, has antibiotic activity.

Tildipirosin is a veterinary antibiotic.

Tildipirosin Basic Attributes

Molecular Weight：

734.018

Exact Mass：

733.524109

UNII：

S795AT66JB

ATC Code：

QJ01FA

Characteristics

PSA：

132.24000

XLogP3：

4.70

Density：

1.2±0.1 g/cm3

Boiling Point：

846.8±65.0 °C at 760 mmHg

Flash Point：

465.9±34.3 °C

Refractive Index：

1.557

Safety Information

GHS Classification：

|Warning|H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]|P201, P202, P260, P261, P272, P280, P281, P302+P352, P308+P313, P314, P321, P333+P313, P363, P405, and P501|Aggregated GHS information provided by 12 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H317: May cause an allergic skin reaction [Warning Sensitization, Skin]|P261, P272, P280, P302+P352, P321, P333+P313, P363, and P501

Drug Information

Drug Indication：

40-mg/ml solution for injection for pigsTreatment and metaphylaxis of swine respiratory disease (SRD) associated with Actinobacillus pleuropneumoniae, Pasteurella multocida, Bordetella bronchiseptica and Haemophilus parasuis sensitive to tildipirosin.The presence of the disease in the herd should be confirmed before metaphylaxis is implemented.180-mg/ml solution for injection for cattleFor the treatment and prevention of bovine respiratory disease (BRD) associated with Mannheimia haemolytica, Pasteurella multocida and Histophilus somni sensitive to tildipirosin.The presence of the disease in the herd should be confirmed before preventive treatment.

MeSH Entry Terms：

20,23-dipiperidinyl-mycaminosyl-tylonolide

Tildipirosin Use and Manufacturing

Uses

Tildipirosin is a novel 16-membered-ring macrolide used in veterinary medicine. Tildipirosin treat bacterial pathogens including Mannheimia haemolytica and Pasteurella multocida that cause respiratory tract infections in cattle and swine. Tildiprosin is a semi-synthetic antibiotic derived from a tylosin derivative by iodination and reaction with piperidine. The introduction of a third basic moiety into the tylosin core provides a wider spectrum of antibiotic action than the dibasic analogues such as tilmicosin, in particular good protection against Pasteurella in livestock. Tildipirosin’s interaction with the ribosomal site of action differs from that of tylosin and tilmicosin.

Use Classification：

Veterinary drugs -> Zuprevo -> EMA Drug Category|Antiinfectives for systemic use -> Veterinary pharmacotherapeutic group|Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients

Computed Properties

Molecular Weight:734.0
XLogP3:4.3
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:11
Rotatable Bond Count:9
Exact Mass:733.52411623
Monoisotopic Mass:733.52411623
Topological Polar Surface Area:132
Heavy Atom Count:52
Complexity:1170
Defined Atom Stereocenter Count:12
Defined Bond Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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