 Home > Encyclopedia > Benfotiamine

Benfotiamine

Benfotiamine structure

CAS No:
22457-89-2
Formula:
C19H23N4O6PS
Chemical Name:
Benfotiamine
Synonyms:
Benzenecarbothioic acid,S-[2-[[(4-amino-2-methyl-5-pyrimidinyl)methyl]formylamino]-1-[2-(phosphonooxy)ethyl]-1-propen-1-yl] ester;Benzoic acid,thio-,S-ester with N-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-N-(4-hydroxy-2-mercapto-1-methyl-1-butenyl)formamide dihydrogen phosphate (ester);Benzenecarbothioic acid,S-[2-[[(4-amino-2-methyl-5-pyrimidinyl)methyl]formylamino]-1-[2-(phosphonooxy)ethyl]-1-propenyl] ester;Formamide,N-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-N-(4-hydroxy-2-mercapto-1-methyl-1-butenyl)-,S-benzoate O-(dihydrogen phosphate);N-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-N-(4-hydroxy-2-mercapto-1-methyl-1-butenyl)formamide S-benzoate O-phosphate;Benfotiamine;Benzoylthiamine monophosphate;Benzoylthiamine O-monophosphate;S-Benzoylthiamine monophosphate;S-Benzoylthiamine O-monophosphate;Biotamin;BTMP;Nitanevril;Neurostop;Vitanevril;Berdi;Betivina;Bietamine;Tabiomyl;Benfothiamine;8088CB;Milgamma;137-74-6
Categories:
Pharmaceutical Intermediates > Antipsychotics

Description

Benfotiamine is a synthetic S-acyl derivative of thiamine (vitamin B1); an antioxidant dietary supplement.IC50 value:Target: Benfotiamine, the lipid-soluble thiamine derivative used as a treatment for diabetic neuropathy, can inhibit three major pathways(the hexosamine pathway, the advanced glycation end product (AGE) formation pathway and the diacylglycerol (DAG)?protein kinase C (PKC) pathway）of hyperglycemic damage and prevent experimental diabetic retinopathy. Benfotiamine is a synth

Benfotiamine Basic Attributes

Molecular Weight：

466.45

Exact Mass：

466.45

EC Number：

245-013-4

UNII：

Y92OUS2H9B

DSSTox ID：

DTXSID3045433

ATC Code：

A - Alimentary tract and metabolism

Characteristics

PSA：

181

XLogP3：

3.84720

Appearance：

shinning black powder

Density：

1.4±0.1 g/cm3

Melting Point：

165 °C (decomp)

Boiling Point：

745.1°C at 760 mmHg

Flash Point：

404.4±35.7 °C

Refractive Index：

1.645

Storage Conditions：

2-8°C

Vapor Pressure：

2.55E-23mmHg at 25°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

20/21/22-36/37/38

safety instructions：

26-36

RTECS Number：

DH6910000

Marks：

Drug Information

MeSH：

Chemicals that bind to and remove ions from solutions. Many chelating agents function through the formation of COORDINATION COMPLEXES with METALS. (See all compounds classified as Chelating Agents.)|Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity. (See all compounds classified as Adjuvants, Immunologic.)

MeSH Entry Terms：

benfothiamine

Benfotiamine Use and Manufacturing

Vitamin B1 analog. Synthetic S-acyl derivative of Thiamine (T344185).

Computed Properties

Molecular Weight:466.4
XLogP3:0.5
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:10
Rotatable Bond Count:10
Exact Mass:466.10759264
Monoisotopic Mass:466.10759264
Topological Polar Surface Area:181
Heavy Atom Count:31
Complexity:697
Undefined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of Benfotiamine

BrightGene Health Technology Co., Ltd Contact Supplier

CN
4 YRS

Business licensed Certified factory

Manufactory Supplier of APIs,Veterinary,Cosmetic Ingredients,Peptides,intermediates,food ingredients

Factory Supply: Benfotiamine 99% White crystalline powder 22457-89-2 HolyPharm

CAS No.: 22457-89-2

Grade: Pharmaceutical Grade

Content: 99%

Inquiry
Dingwang Technology (Wuhan) Co., Ltd. Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of API,nutrition supplements,plant extract,peptide,HCG

Benfotiamine 98% white powder 22457-89-2 Senwayer

CAS No.: 22457-89-2

Grade: Pharmaceutical Grade

Content: 98%

Inquiry
Honour Enterprise Company Limited Contact Supplier

CN
4 YRS

Business licensed

Trader Supplier of Semaglutide,Tirzepatide,API,Enzyme

More than 15 years GMP Factory Suppy 99.5% Benfotiamine Medical Grade CAS22457-89-2

CAS No.: 22457-89-2

Grade: Pharmaceutical Grade

Content: 99.5%

Inquiry
Shaoxing Echem Biopharma Technology Co., Ltd. Contact Supplier

CN
4 YRS

Business licensed

Trader Supplier of Sodium glycocholate,Tetrahydrate Cocarboxylase,cholic acid,Sodium Cholate,Glycocholic acid,Cocarboxylase

Benfotiamine 1

CAS No.: 22457-89-2

Content: 98%

Inquiry
Beton Nutrition Corporation Contact Supplier

CN
3 YRS

Business licensed

Trader Supplier of olive leaf extract,ginger extract,ginseng extract,Black garlic extract,Echinacea purpurea extract,Horse Chestnut Extract,Pueraria extract,Andrographis Extract,citrus aurantium extract,quercetin,Rutin,chlorogenic acid,Curcumin,Apigenin

supply benfotiamine powder

CAS No.: 22457-89-2

Grade: Industrial Grade

Content: 98%

Inquiry