Aminoguanidine hydrochloride
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Aminoguanidine hydrochloride
structure -
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CAS No:
1937-19-5
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Formula:
CH7ClN4
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Chemical Name:
Aminoguanidine hydrochloride
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Synonyms:
Aminoguanadine hydrochloride 98%;Metformin Impurity 15(Aminoguanidine hydrochloride);Aminoguanadine hydrochloride;amino-guanidinhydrochloride;hydrazinecarboximidamidehydrochloride;carbazamidine monohydrochloride;AMINOGUANIDINE HYDROCHLORIDE, 98+%;AMINOGUANIDINE SALT
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CAS No:
Description
white to off-white crystals
Aminoguanidine is equipotent to L-NMMA and L-NNA as an inhibitor of iNOS. The IC50values for inhibition of mouse iNOS and rat nNOS are 5.4 and 160 μM, respectively. Aminoguanidine also inhibits induction of iNOS protein expression by endotoxin in rat macrophages. Aminoguanidine Hydrochloride is used in the synthetic preparation of highly selective and potent G-protein-coupled receptor kinase 2 (GRK2) inhibitor for potential treatment of heart failure.
Aminoguanidine hydrochloride has been reported in a study as inhibitor of animal nitric oxide (NO)-synthase. Crystal structure of aminoguanidine hydrochloride has been investigated by Fourier and least squares method. Its crystals were monoclinic and the guanidine part of the aminoguanidinium ion is planar.
Aminoguanidine hydrochloride Basic Attributes
110.54608
110.035927
3909606
217-707-7
TSCA listed
White to off-white
29280000
Characteristics
90.4
White to off-white Crystals
162-166 °C(lit.)
261.4°C at 760 mmHg
111.9ºC
506.7g/L at 20℃
Store at RT
0Pa at 25℃
Subcutaneous-rat LDL0: 2984 mg/kg
Not classified
Keep in dark place,Sealed in dry,Room Temperature
Safety Information
NONH for all modes of transport
3
Xi
26-36
ME8430000
Xi
Warehouse ventilated, low temperature and dry
P261-P305 + P351 + P338
36/37/38
Aminoguanidine hydrochloride Use and Manufacturing
a-Glucosidase inhibitor; hydroxyethyl derivative of 1-deoxynojirimycin
antitussive
Aminoguanidine hydrochloride may be employed as nitric oxide synthase (NOS) inhibitor to investigate its effect on the reduction of alveolar bone loss in ligature induced periodontitis in rats. It may be used in the synthesis of 5-guanylhydrazone derivatives, having antibacterial activity against antibacterial activity against bothEscherichia coliandStaphylococcus aureus.
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