 Home > Encyclopedia > Foscarnet sodium

Foscarnet sodium

Foscarnet sodium structure

CAS No:
63585-09-1
Formula:
CH3O5P.3Na
Chemical Name:
Foscarnet sodium
Synonyms:
Phosphinecarboxylic acid,1,1-dihydroxy-,1-oxide,sodium salt (1:3);Phosphinecarboxylic acid,dihydroxy-,oxide,trisodium salt;Trisodium phosphonoformate;A 29622;Phosphonoformic acid trisodium salt;Foscarnet sodium;PFA;Triapten;EHB 776;Foscavir;Gefin;Trisodium phosphonatoformate;884236-24-2
Categories:
Active Pharmaceutical Ingredients > Synthetic Anti-infective Drugs

Description

ChEBI: The trisodium salt of phosphonoformic acid. It is used as an antiviral agent in the treatment of cytomegalovirus retinitis (CMV retinitis, an inflamation of the retina that can lead to blindness) and as an alternative to ganciclovir for AIDS patients who r quire concurrent antiretroviral therapy but are unable to tolerate ganciclovir due to haematological toxicity.

Trisodium phosphonoformate is the trisodium salt of phosphonoformic acid. It is used as an antiviral agent in the treatment of cytomegalovirus retinitis (CMV retinitis, an inflamation of the retina that can lead to blindness) and as an alternative to ganciclovir for AIDS patients who require concurrent antiretroviral therapy but are unable to tolerate ganciclovir due to haematological toxicity. It has a role as an antiviral drug. It is an organic sodium salt and a one-carbon compound. It contains a phosphonatoformate.|An antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpesviruses and HIV.

Foscarnet sodium Basic Attributes

Molecular Weight：

191.95

Exact Mass：

191.918

EC Number：

1312995-182-4

UNII：

8C5OQ81LWT

DSSTox ID：

DTXSID6023078

HScode：

2942000000

Characteristics

PSA：

103

XLogP3：

-0.61620

Appearance：

White or almost white crystalline powder

Melting Point：

>250 °C

Boiling Point：

490.7°C at 760 mmHg

Flash Point：

250.6ºC

Storage Conditions：

Store in original container in a cool dark place.

Toxicity：

LD50 i.p. in mice: 2000-4000 mmol/kg (Eriksson)

Safety Information

Packing level：

Transport codes：

UN 2811 6.1/PG 3

wgk germany：

hazard class code：

R36/37/38

safety instructions：

S26; S36

Marks：

Precautionary statement(s)：

P201, P202, P260, P281, P308+P313, P314, P405, P501

Hazard Statements：

H341

GHS Classification：

|Warning|H341 (100%): Suspected of causing genetic defects [Warning Germ cell mutagenicity]|P201, P202, P260, P281, P308+P313, P314, P405, and P501|Aggregated GHS information provided by 9 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly. (See all compounds classified as Antiviral Agents.)|Inhibitors of reverse transcriptase (RNA-DIRECTED DNA POLYMERASE), an enzyme that synthesizes DNA on an RNA template. (See all compounds classified as Reverse Transcriptase Inhibitors.)

MeSH Entry Terms：

Foscarnet

Foscarnet sodium Use and Manufacturing

Methods of Manufacturing

Method 1: In the absence of organic base, phosphorus trichloride and ethanol produce diethyl phosphite; in the presence of organic base, triethyl phosphite is obtained. After the reaction between triethyl phosphite and ethyl chloroformate at 160℃, the fractions of 148～150℃/2.40kPa are collected to obtain triethylphosphonate with a yield of 71%. And diethyl phosphite in anhydrous ether, in the presence of sodium metal, and ethyl chloroformate reaction at room temperature, can also get triethyl phosphonate, yield 80%. 21 parts of triethyl phosphonate were dissolved in 60 parts of water containing 24 parts of 50% sodium hydroxide and refluxed for 2 hours. After cooling overnight, 4.7 parts of sodium phosphonate hexahydrate were filtered, melting point> 250°C. Method 2: Newly prepared sodium cyanide was placed in carbon tetrachloride, and equimolar diethyl phosphite was added dropwise at about 10°C, and then reacted at 35°C for 3 hours. Filtration, concentration and distillation under reduced pressure to obtain diethyl cyanophosphate, yield 72%, boiling point 88～91℃/1.46kPa. It was refluxed with 40% sodium hydroxide for 2h, filtered, and recrystallized with water to obtain sodium foscarnet hexahydrate with a yield of 52% and a melting point of >250°C.

Uses

Inhibits viral DNA polymerase and reverse transcriptase. Antiviral.

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:191.95
Hydrogen Bond Acceptor Count:5
Exact Mass:191.91764294
Monoisotopic Mass:191.91764294
Topological Polar Surface Area:103
Heavy Atom Count:10
Complexity:103
Covalently-Bonded Unit Count:4
Compound Is Canonicalized:Yes

Material

Diethyl phosphite

Drug Function and Efficacy

Unspecified

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Sodium foscarnet

Foscarnet Sodium Glucose Injection
Ingredients	Sodium foscarnet
Specifications	100ml: 1.2g sodium foscarnet and 3g glucose

Sodium foscarnet
Specifications	————
Manufacturer	Jinan JINDA Pharmaceutical Chemistry Co., Ltd.

See More Related Drugs

Registered Holders

MAITHRI DRUGS PRIVATE LTD

United States
Active
CHEM WERTH INC

United States
Active
EMCURE PHARMACEUTICALS LTD

United States
Active

See More Registered Holders

Recommended Suppliers of Foscarnet sodium

Hangzhou KieRay Chem Co.,LTD Contact Supplier

CN
5 YRS

Business licensed Certified factory

Manufactory Supplier of fine chemicals,pharmaceutical materials

Foscarnet sodium

CAS No.: 63585-09-1

Grade: industrial Grade

Content: 98%

Inquiry
HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives

Foscarnet sodium

CAS No.: 63585-09-1

Content: 99.00%

Inquiry
Shandong Airuike Chemical Co., Ltd. Contact Supplier

CN
3 YRS

Business licensed

Trader Supplier of api,Intermediates,Organic Chemistry,Inorganic Chemistry,Daily Chemicals,Cosmetic Raw Materals,CATALYST AND AUXILIARY,FLAVORS AND FRAGRANCES,Chemical Pesticides,ADDITIVE

Foscarnet sodium CAS63585-09-1

CAS No.: 63585-09-1

Grade: Pharmaceutical Grade

Content: 99%

Inquiry