1,3-Benzenediamine, 4-methyl-, coupled with diazotized aniline, diazotized o(orp)-toluidine and m-phenylenediamine, acetates hydrochlorides Safety Data Sheets

no data available

If inhaled

Following skin contact

Following eye contact

Following ingestion

Exposure Routes: inhalation, skin absorption, ingestion, skin and/or eye contact Symptoms: Irritation eyes, skin, nose, throat; dermatitis; ataxia, tachycardia, nausea, vomiting, convulsions, respiratory depression; methemoglobinemia, cyanosis, headache, lassitude (weakness, exhaustion), dizziness, bluish skin; liver injury; [potential occupational carcinogen] Target Organs: Eyes, skin, respiratory system, blood, cardiovascular system, liver (NIOSH, 2016)

Special Hazards of Combustion Products: Toxic fumes are generated when heated. Behavior in Fire: Toxic gases are produced when heated to decomposition temperature. (USCG, 1999)

Wear self-contained breathing apparatus for firefighting if necessary.

Avoid dust formation. Avoid breathing mist, gas or vapours.Avoid contacting with skin and eye. Use personal protective equipment.Wear chemical impermeable gloves. Ensure adequate ventilation.Remove all sources of ignition. Evacuate personnel to safe areas.Keep people away from and upwind of spill/leak.

Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Do NOT wash away into sewer. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Then store and dispose of according to local regulations.

Spillage Disposal. Personal protection: chemical protection suit including self-contained breathing apparatus. Do not let this chemical enter the environment. Do not wash away into sewer. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Then store and dispose of according to local regulations.

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Well closed. Separated from oxidants and acids. Separated from food and feedstuffs. Store in an area without drain or sewer access. Do NOT store or transport in containers made from aluminium or copper and its alloys. Provision to contain effluent from fire extinguishing.PRECAUTIONS FOR "CARCINOGENS": Storage site should be as close as practical to lab in which carcinogens are to be used, so that only small quantities required for ... expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion-proof refrigerator or freezer (depending on chemicophysical properties ...) that bears appropriate label. An inventory ... should be kept, showing quantity of carcinogen & date it was acquired ... Facilities for dispensing ... should be contiguous to storage area. Chemical Carcinogens

Occupational Exposure limit values

Biological limit values

Eye/face protection

Skin protection

Respiratory protection

Thermal hazards

NIOSH considers toluenediamine to be a potential occupational carcinogen. Toluenediamine

Decomposes on heating. This produces toxic and corrosive fumes including nitrogen oxides. Reacts with oxidants and acids. This generates fire and explosion hazard. Attacks copper and its alloys and aluminium.

Readily becomes oxidized in neutral or alkaline soln to form dark products

If dry, it can be charged electrostatically by swirling, pneumatic transport, pouring, etc. Dust explosion possible if in powder or granular form, mixed with air.2,4-TOLUENEDIAMINE neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. May generate hydrogen, a flammable gas, in combination with strong reducing agents such as hydrides. Reacts vigorously with oxidizing agents (USCG, 1999).

no data available

STABILITY: This chemical is sensitive to air and moisture. It is sensitive to temperatures greater than 104 F. It is also sensitive to prolonged exposure to light. This compound readily becomes oxidized in neutral or alkaline solutions to form a dark product. Solutions of this chemical in water, DMSO, 95% ethanol or acetone should be stable for 24 hours under normal lab conditions.REACTIVITY: This compound may react with acids, acid chlorides, acid anhydrides, strong oxidizing agents and chloroformates. It is also incompatible with isocyanates. (NTP, 1992)

When heated to decomposition it emits toxic fumes of nitrogen oxides.

Acute toxicity

• Oral: LDLo Rat oral 500 mg/kg.
• Inhalation: no data available
• Dermal: no data available

Skin corrosion/irritation

Serious eye damage/irritation

Respiratory or skin sensitization

Germ cell mutagenicity

Carcinogenicity

Reproductive toxicity

STOT-single exposure

STOT-repeated exposure

Aspiration hazard

• Toxicity to fish: LC50; Species: Pimephales promelas (fathead minnow); Conditions: flow through bioassay with measured concentrations, 24.2 deg C, dissolved oxygen 6.5 mg/L, hardness 46.3 mg/L calcium carbonate, alkalinity 123 mg/L calcium carbonate, and pH 7.6; Concentration: 1420 mg/L for 96 hr
• Toxicity to daphnia and other aquatic invertebrates: EC50; Species: Daphnia magna (Water Flea) age <24 hr, Lake Langedam strain; Conditions: freshwater, static, 20 deg C, pH 7.8-8.0, hardness 250 mg/L CaCO3, dissolved oxygen 94-99%; Concentration: 12000 ug/L for 24 hr; Effect: intoxication, immobilization /98% purity
• Toxicity to algae: EC50; Species: Pseudokirchneriella subcapitata (Green Alga) exponential growth phase; Conditions: freshwater, static, 25 deg C, pH 6.0-7.5; Concentration: 78.1 ug/L for 96 hr (95% confidence interval: 60-100.7 ug/L); Effect: decreased population abundance /formulation
• Toxicity to microorganisms: no data available

AEROBIC: Toluene-2,4-diamine, present at 100 mg/L, reached 0% of its theoretical BOD in 2 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test(1). A decline of 45% in the theoretical organic carbon of toluene-2,4-diamine was observed after 4 hr exposure to activated sludge in a fill and draw apparatus(2). When incubated with a synthetic batch activated sludge acclimated to the 2,4- and 2-6-isomers, diaminotoluenes, present at 300 mg/L, were 80% biodegraded in 4 days(3). Toluene-2,4-diamine, (ring-labeled), produced 35% 14-CO2 evolution in 375 days using a soil inoculum in the shake flask test(4). Adsorption to soil is expected to attenuate biodegradation(5). Using an inoculum from a munitions manufacturing wastewater treatment plant in Radford, VA, toluene-2,4-diamine, present at 500 mg/L, yielded 41.1 mg COD, with each 0.55 mM addition being consumed within 2-4 days(6).

A BCF range of 1.9-3.3 was measured in fish for toluene-2,4-diamine, present at 1 mg/L, and orange-red killifish (Oryzias latipes) which were exposed over an 6-week period(1). According to a classification scheme(3), this BCF range suggests the potential for bioconcentration in aquatic organisms is low(SRC).

Using aerobic conditions with a Washington silt loam surface soil (21% sand; 60% silt; 19% clay; pH 5; 1.3% total organic carbon) from a farm field planted with a rotation of corn and soybeans near Bethehem, PA and a Freehold sandy loam soil (53% sand; 40% silt; 7% clay; pH 5.8; 1.6% total organic carbon) from the Rutgers Experimental Farm, Adelphia, NJ, the Koc of toluene-2,4-diamine were measured to be 1331 and 1346, respectively. Under anaerobic conditions, Koc values were 713 and 1054, respectively(1). According to a classification scheme(2), this estimated Koc value suggests that toluene-2,4-diamine is expected to have low mobility in soil. The estimated pKa of toluene-2,4-diamine is 5.35(3), indicating that this compound will exist partially in the cation form in the environment and cations generally adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(4). Aromatic amines are expected to bind strongly to humus or organic matter in soils due to the high reactivity of the aromatic amino group(5,6), suggesting that mobility may be much lower in some soils(SRC).

no data available

Product

Contaminated packaging

no data available

no data available

Information on revision

Abbreviations and acronyms

• CAS: Chemical Abstracts Service
• ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
• RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
• IMDG: International Maritime Dangerous Goods
• IATA: International Air Transportation Association
• TWA: Time Weighted Average
• STEL: Short term exposure limit
• LC50: Lethal Concentration 50%
• LD50: Lethal Dose 50%
• EC50: Effective Concentration 50%

References

• IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
• HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
• IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
• eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
• CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
• ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
• ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
• Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
• ECHA - European Chemicals Agency, website: https://echa.europa.eu/