Hexamethylene diisocyanate Safety Data Sheets

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SAFETY DATA SHEETS

According to the UN GHS revision 8

Version: 1.0

Creation Date: July 15, 2019

Revision Date: July 15, 2019

SECTION 1: Identification

1.1 GHS Product identifier

Product name	Hexamethylene diisocyanate

1.2 Other means of identification

Product number	-
Other names	hexamethylene-1,6-diisocyanate; 1,6-diisocyanato-hexan; 1,6-diisocyanato hexane

1.3 Recommended use of the chemical and restrictions on use

Identified uses	One of the main uses of hexamethylene diisocyanate is as a polymerizing agent in polyurethane spray paint formulations and coatings (e.g., automobile paint). Hexamethylene diisocyanate is used in the preparation of dental materials, contact lenses, and medical adsorbents.
Uses advised against	no data available

1.4 Supplier's details

Company	Echemi.com
Address	Echemi.com
Telephone	Echemi.com

1.5 Emergency phone number

Emergency phone number	Echemi.com
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

SECTION 2: Hazard identification

2.1 Classification of the substance or mixture

Skin irritation, Category 2

Eye irritation, Category 2

Skin sensitization, Category 1

Acute toxicity - Category 3, Inhalation

Specific target organ toxicity â single exposure, Category 3

Respiratory sensitization, Category 1

2.2 GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Danger
Hazard statement(s)	H315 Causes skin irritation H319 Causes serious eye irritation H317 May cause an allergic skin reaction H331 Toxic if inhaled H335 May cause respiratory irritation H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled
Prevention	P264 Wash ... thoroughly after handling. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P272 Contaminated work clothing should not be allowed out of the workplace. P271 Use only outdoors or in a well-ventilated area. P284 [In case of inadequate ventilation] wear respiratory protection.
Response	P302+P352 IF ON SKIN: Wash with plenty of water/... P321 Specific treatment (see ... on this label). P332+P317 If skin irritation occurs: Get medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P333+P317 If skin irritation or rash occurs: Get medical help. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P316 Get emergency medical help immediately. P319 Get medical help if you feel unwell. P342+P316 If experiencing respiratory symptoms: Get emergency medical help immediately.
Storage	P403+P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

2.3 Other hazards which do not result in classification

no data available

SECTION 3: Composition/information on ingredients

3.1 Substances

Chemical name	Common names and synonyms	CAS number	EC number	Concentration
Hexamethylene diisocyanate	Hexamethylene diisocyanate	822-06-0	212-485-8	100%

SECTION 4: First-aid measures

4.1 Description of necessary first-aid measures

If inhaled

Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.

Following skin contact

Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention .

Following eye contact

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Following ingestion

Rinse mouth. Refer for medical attention .

4.2 Most important symptoms/effects, acute and delayed

Excerpt from ERG Guide 156 [Substances - Toxic and/or Corrosive (Combustible / Water-Sensitive)]: TOXIC; inhalation, ingestion or contact (skin, eyes) with vapors, dusts or substance may cause severe injury, burns or death. Contact with molten substance may cause severe burns to skin and eyes. Reaction with water or moist air will release toxic, corrosive or flammable gases. Reaction with water may generate much heat that will increase the concentration of fumes in the air. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution. (ERG, 2016)

4.3 Indication of immediate medical attention and special treatment needed, if necessary

Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. Isocyanates, aliphatic thiocyanates, and related compounds

SECTION 5: Fire-fighting measures

5.1 Suitable extinguishing media

If material on fire or involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not bur or burns with difficulty.) use water in flooding quantities as fog. Use foam, dry chemical, or carbon dioxide. Keep run-off water out of sewers and water sources.

5.2 Specific hazards arising from the chemical

Excerpt from ERG Guide 156 [Substances - Toxic and/or Corrosive (Combustible / Water-Sensitive)]: Combustible material: may burn but does not ignite readily. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water. (ERG, 2016)

5.3 Special protective actions for fire-fighters

Use powder, carbon dioxide.

SECTION 6: Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Evacuate danger area! Consult an expert! Personal protection: complete protective clothing including self-contained breathing apparatus. Ventilation. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

6.2 Environmental precautions

Evacuate danger area! Consult an expert! Personal protection: complete protective clothing including self-contained breathing apparatus. Ventilation. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

6.3 Methods and materials for containment and cleaning up

Environmental considerations: Air spill: Apply water spray or mist to knock down vapors.

SECTION 7: Handling and storage

7.1 Precautions for safe handling

NO open flames. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

7.2 Conditions for safe storage, including any incompatibilities

Separated from incompatible materials and food and feedstuffs. See Chemical Dangers. Cool. Dry. Keep in the dark. Ventilation along the floor.Isocyanates are transported in railroad tank cars, tank trucks, tanks in ships, containers, and drums. They are stored in steel tanks and processed in steel equipment. For long-term storage stainless steel is recommended. To avoid contamination by atmospheric moisture, a dry air or inert gas blanket is essential. Isocyanates

SECTION 8: Exposure controls/personal protection

8.1 Control parameters

Occupational Exposure limit values

TLV: 0.005 ppm as TWA.MAK: 0.035 mg/m3, 0.005 ppm; peak limitation category: I(1); sensitization of respiratory tract and skin (SAH); pregnancy risk group: D

Biological limit values

no data available

8.2 Appropriate engineering controls

Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.

8.3 Individual protection measures, such as personal protective equipment (PPE)

Eye/face protection

Wear face shield or eye protection in combination with breathing protection.

Skin protection

Protective gloves.

Respiratory protection

Use ventilation, local exhaust or breathing protection.

Thermal hazards

no data available

SECTION 9: Physical and chemical properties and safety characteristics

Physical state	Hexamethylene diisocyanate is a colorless crystalline solid. Toxic by ingestion and is strongly irritating to skin and eyes. It is used to make nylon.
Colour	Liquid
Odour	Sharp, pungent odor
Melting point/freezing point	-46Â°C(lit.)
Boiling point or initial boiling point and boiling range	82-85Â°C/0.1mmHg
Flammability	Class IIIB Combustible Liquid: Fl.P. at or above 200Â°F.
Lower and upper explosion limit/flammability limit	no data available
Flash point	135Â°C
Auto-ignition temperature	454Â°C
Decomposition temperature	no data available
pH	no data available
Kinematic viscosity	no data available
Solubility	Reacts with water (NTP, 1992)
Partition coefficient n-octanol/water	log Kow = 3.20 (est)
Vapour pressure	0.05 mm Hg ( 25 Â°C)
Density and/or relative density	1.047g/mLat 20Â°C(lit.)
Relative vapour density	5.81 (Air = 1)
Particle characteristics	no data available

SECTION 10: Stability and reactivity

10.1 Reactivity

The substance polymerizes under the influence of temperatures above 93Â°C. On combustion, forms toxic and corrosive fumes including nitrogen oxides and hydrogen cyanide (see ICSC 0492). Decomposes on contact with water. This produces amine and polyureas. Reacts violently with acids, alcohols, amines, bases and oxidants. This generates fire and explosion hazard. Attacks copper.

10.2 Chemical stability

no data available

10.3 Possibility of hazardous reactions

HEXAMETHYLENE DIISOCYANATE reacts with water. Base-catalyzed reactions of this compound with alcohols may be explosively violent in the absence of diluting solvents. This chemical is incompatible with strong bases, amines, acids and strong oxidizers. It is also incompatible with metal compounds and surface active materials. (NTP, 1992).

10.4 Conditions to avoid

no data available

10.5 Incompatible materials

Base-catalyzed reactions of isocyanates such as hexamethylene diisocyanate with alcohols should generally be carried out in inert solvents. Such reactions in the absence of solvents often occur with explosive violence.

10.6 Hazardous decomposition products

When heated to decomposition it emits toxic fumes of /nitrogen oxides/.

SECTION 11: Toxicological information

Acute toxicity

Oral: LD50 Mouse oral 350 mg/kg
Inhalation: LC50 Rat (male) inhalation 40 ppm/1 hr.
Dermal: no data available

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available

Carcinogenicity

no data available

Reproductive toxicity

No information is available on the reproductive or developmental effects of hexamethylene diisocyanate in humans. There was no effect on male or female reproductive organs in one rat inhalation study.

STOT-single exposure

The substance is severely irritating to the eyes. The substance is irritating to the skin and respiratory tract. Inhalation may cause asthmatic reactions.

STOT-repeated exposure

Repeated or prolonged contact may cause skin sensitization. Repeated or prolonged inhalation may cause asthma. See Notes.

Aspiration hazard

A harmful contamination of the air will be reached rather slowly on evaporation of this substance at 20Â°C; on spraying or dispersing, however, much faster.

SECTION 12: Ecological information

12.1 Toxicity

Toxicity to fish: no data available
Toxicity to daphnia and other aquatic invertebrates: no data available
Toxicity to algae: no data available
Toxicity to microorganisms: no data available

12.2 Persistence and degradability

no data available

12.3 Bioaccumulative potential

Hexamethylene diisocyanate reacts readily with water to form amines and polyureas(1-3); therefore, bioconcentration of monomeric hexamethylene diisocyanate in aquatic organisms is not expected to be an important environmental fate process(SRC).

12.4 Mobility in soil

Hexamethylene diisocyanate reacts readily with water to form amines and polyureas(1-3); therefore, adsorption of monomeric hexamethylene diisocyanate in soil is not expected to be an important environmental fate process(SRC).

12.5 Other adverse effects

no data available

SECTION 13: Disposal considerations

13.1 Disposal methods

Product

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

SECTION 14: Transport information

14.1 UN Number

ADR/RID: UN2206 (For reference only, please check.)

IMDG: UN2206 (For reference only, please check.)

IATA: UN2206 (For reference only, please check.)

14.2 UN Proper Shipping Name

ADR/RID: ISOCYANATES, TOXIC, N.O.S. or ISOCYANATE SOLUTION, TOXIC, N.O.S. (For reference only, please check.)

IMDG: ISOCYANATES, TOXIC, N.O.S. or ISOCYANATE SOLUTION, TOXIC, N.O.S. (For reference only, please check.)

IATA: ISOCYANATES, TOXIC, N.O.S. or ISOCYANATE SOLUTION, TOXIC, N.O.S. (For reference only, please check.)

14.3 Transport hazard class(es)

ADR/RID: 6.1 (For reference only, please check.)

IMDG: 6.1 (For reference only, please check.)

IATA: 6.1 (For reference only, please check.)

14.4 Packing group, if applicable

ADR/RID: II (For reference only, please check.)

IMDG: II (For reference only, please check.)

IATA: II (For reference only, please check.)

14.5 Environmental hazards

ADR/RID: No

IMDG: No

IATA: No

14.6 Special precautions for user

no data available

14.7 Transport in bulk according to IMO instruments

no data available

SECTION 15: Regulatory information

15.1 Safety, health and environmental regulations specific for the product in question

Chemical name	Common names and synonyms	CAS number	EC number
Hexamethylene diisocyanate	Hexamethylene diisocyanate	822-06-0	212-485-8
European Inventory of Existing Commercial Chemical Substances (EINECS)			Listed.
EC Inventory			Listed.
United States Toxic Substances Control Act (TSCA) Inventory			Listed.
China Catalog of Hazardous chemicals 2015			Listed.
New Zealand Inventory of Chemicals (NZIoC)			Listed.
Philippines Inventory of Chemicals and Chemical Substances (PICCS)			Listed.
Vietnam National Chemical Inventory			Listed.
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC)			Listed.
Korea Existing Chemicals List (KECL)			Listed.

SECTION 16: Other information

Information on revision

Creation Date	July 15, 2019
Revision Date	July 15, 2019

Abbreviations and acronyms

CAS: Chemical Abstracts Service
ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
IMDG: International Maritime Dangerous Goods
IATA: International Air Transportation Association
TWA: Time Weighted Average
STEL: Short term exposure limit
LC50: Lethal Concentration 50%
LD50: Lethal Dose 50%
EC50: Effective Concentration 50%

References

IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Other Information

The symptoms of asthma often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation are therefore essential.Anyone who has shown symptoms of asthma due to this substance should avoid all further contact.Anyone who has shown skin sensitization due to this substance should avoid all further contact.Workers exposed to this compound may also be sensitized to other isocyanates.The odour warning when the exposure limit value is exceeded is insufficient.Do NOT take working clothes home.

Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.

Hexamethylene diisocyanate is included in Organic Reagents category.