Propazine Safety Data Sheets

Carcinogenicity, Category 2

Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1

If inhaled

Following skin contact

Following eye contact

Following ingestion

no data available

Combustible. Gives off irritating or toxic fumes (or gases) in a fire. Heating will cause rise in pressure with risk of bursting.

Use water spray, foam, powder, carbon dioxide.

Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.

Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.

Evacuate persons not wearing protective equipment from area of spill or leak until clean-up is complete. Remove all ignition sources. Collect powdered material in the most convenient and safe manner and deposit in sealed containers. Ventilate area after clean-up is complete. It may be necessary to contain and dispose of this chemical as a hazardous waste. If material or contaminated runoff enters waterways, notify downstream users of potentially contaminated waters. Contact your Department of Environmental Protection or your regional office of the federal EPA for specific recommendations. If employees are required to clean-up spills, they must be properly trained and equipped. OSHA 1910.120(q) may be applicable.

NO open flames. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Provision to contain effluent from fire extinguishing. Store in an area without drain or sewer access.Do not contaminate water, food or feed by storage or disposal. ... Store product in original container only, away from other pesticides, fertilizer, food for feed. Propazine 4L

Occupational Exposure limit values

Biological limit values

Eye/face protection

Skin protection

Respiratory protection

Thermal hazards

Decomposes on heating and on burning. This produces toxic gases of nitrogen oxides and chlorine.

Very stable over several yr of shelf life, with only slight sensitivity to light & extreme temp which would occur normally

NONFLAMMABLE.

no data available

no data available

When heated to decomposition it emits toxic fumes of nitroxides and Cl-.

Acute toxicity

• Oral: LD50 Rat oral > 7000 mg/kg
• Inhalation: LC50 Rabbit inhalation 2.04 mg/l/4 hr Milogard 80W
• Dermal: LD50 Rat percutaneous > 3100 mg/kg

Skin corrosion/irritation

Serious eye damage/irritation

Respiratory or skin sensitization

Germ cell mutagenicity

Carcinogenicity

Reproductive toxicity

STOT-single exposure

STOT-repeated exposure

Aspiration hazard

• Toxicity to fish: LC50 Lepomis macrochirus (bluegill sunfish) > 100 mg/L for 96 hr /Technical; Conditions of bioassay not specified
• Toxicity to daphnia and other aquatic invertebrates: EC50; Species: Daphnia magna (Water flea, <24 hr); Conditions: freshwater, static, 21 deg C; Concentration: 8600 ug/L for 24 hr; Effect: intoxicaiton, immobilization /96-99.9% purity
• Toxicity to algae: no data available
• Toxicity to microorganisms: no data available

AEROBIC: In soil, microbial degradation of propazine occurs, with hydrolysis of the chlorine atom to give hydroxypropazine, dealkylation of both substituted amino groups, presumably followed by ring opening and decomposition(1). The half-life in soil is approximately 80-100 days(1). Propazine was 36-64% degraded in a series of aerobic soil beds over a 54 week incubation period and 5.7-75% degraded in a series of anaerobic/aerobic cycled soil beds over a 54 week incubation period(2). In lab tests, no 14-CO2 release was observed in 16 weeks from a silt loam soil treated with propazine labeled with 14-C in the triazine ring(3). Two to fourteen months time has been reported as the time required for decomposition of propazine applied at "normal" application rates in soil(4); however, it was not reported whether this refers to total degradation of parent herbicide as well as active metabolites(SRC). The half-lives for degradation (purportedly mainly soil-catalyzed hydrolysis) of propazine in Hatzenbuhl soil at pH 4.8 and Neuhofen soil at pH 6.5 are 62 and 127 days, respectively(5). It has been reported that s-triazines which are similar in structure to propazine can be utilized by certain soil microorganisms as a source of energy(6).

An estimated BCF of 17 was calculated in fish for propazine(SRC), using a log Kow of 2.93(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

An avg Koc of 154 was calculated for propazine from 33 soils(1) and an avg Koc of 160 was calculated from 54 soils(2). The Koc of propazine in 4 European soils was measured in the range of 84-500(3). According to a classification scheme(4), this Koc data suggests that propazine is expected to have moderate mobility in soil.

no data available

Product

Contaminated packaging

no data available

no data available

Information on revision

Abbreviations and acronyms

• CAS: Chemical Abstracts Service
• ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
• RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
• IMDG: International Maritime Dangerous Goods
• IATA: International Air Transportation Association
• TWA: Time Weighted Average
• STEL: Short term exposure limit
• LC50: Lethal Concentration 50%
• LD50: Lethal Dose 50%
• EC50: Effective Concentration 50%

References

• IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
• HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
• IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
• eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
• CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
• ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
• ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
• Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
• ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Other Information

Health effects of exposure to the substance have not been investigated adequately.