2,5-Dinitrotoluene Safety Data Sheets

Acute toxicity - Category 3, Oral

Acute toxicity - Category 3, Dermal

Acute toxicity - Category 3, Inhalation

Germ cell mutagenicity, Category 2

Carcinogenicity, Category 1B

Specific target organ toxicity – repeated exposure, Category 2

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 2

Reproductive toxicity, Category 2

If inhaled

Following skin contact

Following eye contact

Following ingestion

no data available

Combustible. Gives off irritating or toxic fumes (or gases) in a fire. Finely dispersed particles form explosive mixtures in air.

Use water spray, powder, foam, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water. Combat fire from a sheltered position.

Consult an expert! Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Sweep spilled substance into sealable containers. Carefully collect remainder. Then store and dispose of according to local regulations.

Consult an expert! Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Sweep spilled substance into sealable containers. Carefully collect remainder. Then store and dispose of according to local regulations.

1) remove all ignition sources. 2) ventilate area of spill. 3) for small quantities, sweep onto paper or other suitable material & burn in suitable combustion chamber which allows burning in unconfined condition & is equipped with appropriate effluent gas cleaning device. large quantities may be reclaimed...if...not practical, dissolve in fuel oil & atomize in suitable combustion chamber equipped with appropriate effluent gas cleaning device. dinitrotoluene

NO open flames. Closed system, dust explosion-proof electrical equipment and lighting. Prevent deposition of dust. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Fireproof. Separated from strong oxidants, food and feedstuffs and incompatible materials. See Chemical Dangers. Well closed. Keep in a well-ventilated room. Store in an area without drain or sewer access. Provision to contain effluent from fire extinguishing.Normally stored as a molten liquid. Separate from strong oxidizers & reducing agents. Hot water coils should not exceed 194 deg F (90 deg C). Dinitrotoluenes

Occupational Exposure limit values

Biological limit values

Eye/face protection

Skin protection

Respiratory protection

Thermal hazards

NIOSH considers dinitrotoluene to be a potential occupational carcinogen. [50 mg/cu m] Dinitrotoluene

May explode on heating. Decomposes on heating. This produces toxic fumes including nitrogen oxides even in the absence of air. Reacts with strong oxidants. Reacts with reducing agents, strong bases, amines, zinc and tin.

no data available

Combustible material. /3,4-Dinitrotoluene/Dust explosion possible if in powder or granular form, mixed with air.

no data available

no data available

When heated to decomposition it emits toxic fumes of /nitrogen oxides/.

Acute toxicity

• Oral: LD50 Rat oral 707 mg/kg
• Inhalation: no data available
• Dermal: no data available

Skin corrosion/irritation

Serious eye damage/irritation

Respiratory or skin sensitization

Germ cell mutagenicity

Carcinogenicity

Reproductive toxicity

STOT-single exposure

STOT-repeated exposure

Aspiration hazard

• Toxicity to fish: LC50; Species: Pimephales promelas (Fathead Minnow) juvenile; Conditions: freshwater, static, 20 deg C, pH 7.2-8.6, hardness 26 mg/L CaCO3, alkalinity 45 mg/L CaCO3, dissolved oxygen 6.8 (4.7-9.2) mg/L; Concentration: 1300 ug/L for 96 hr /formulation
• Toxicity to daphnia and other aquatic invertebrates: EC50; Species: Daphnia magna (Water Flea) 1st instar larva; Conditions: freshwater, static, 20 deg C, pH 7.2-8.6, hardness 26 mg/L CaCO3, alkalinity 45 mg/L CaCO3, dissolved oxygen 8.8 mg/L; Concentration: 3400 ug/L for 48 hr; Effect: intoxication, immobilization /formulation
• Toxicity to algae: no data available
• Toxicity to microorganisms: no data available

AEROBIC: 2,5-Dinitrotoluene was not mineralized in water from a pond and from Waconda Bay; however, 2,5-dinitrotoluene was co-metabolized when 500 ppm of yeast extract were added to the water from these two sources(1). The rate of degradation with added yeast extract in Searsville Pond water was 2.3X10+10 mL/cell-hour, and in Waconda Bay water was 12X10+10 mL/cell-hour(1). Analogous compound 2,4-dinitrotoluene was used as the sole carbon source and mineralized in natural surface water that had been acclimated to 120 ppm 2,4-dinitrotoluene; after a 2-3 day lag period, >90% of 10 ppm 2,4-dinitrotoluene was transformed in aerated water after 6 days of incubation(2). Mixed dinitrotoluene isomers, present at 100 mg/L, reached 0% of its theoretical BOD in 2 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test that suggests the compound is not readily biodegradable(3).

An estimated BCF of 13 was calculated for 2,5-dinitrotoluene(SRC), using an estimated log Kow of 2.18(1) and a regression-derived equation(1). The BCF for dinitrotoluene (mixed isomers) has been measured to be low (BCF values of 0.6 to 21.2) in carp (Carprinus carpio)(2). According to a classification scheme(2), these BCF values suggest the potential for bioconcentration in aquatic organisms is low.

Using a structure estimation method based on molecular connectivity indices(1), the Koc for 2,5-dinitrotoluene can be estimated to be 575(SRC). According to a classification scheme(2), this estimated Koc value suggests that 2,5-dinitrotoluene is expected to have medium mobility in soil.

no data available

Product

Contaminated packaging

no data available

no data available

Information on revision

Abbreviations and acronyms

• CAS: Chemical Abstracts Service
• ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
• RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
• IMDG: International Maritime Dangerous Goods
• IATA: International Air Transportation Association
• TWA: Time Weighted Average
• STEL: Short term exposure limit
• LC50: Lethal Concentration 50%
• LD50: Lethal Dose 50%
• EC50: Effective Concentration 50%

References

• IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
• HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
• IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
• eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
• CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
• ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
• ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
• Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
• ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Other Information

Combustion in a confined space may turn into detonation.Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available.Do NOT take working clothes home.See ICSCs 0726, 0727, 0728 and 0729.