Chlorobenzilate Safety Data Sheets

Acute toxicity - Category 4, Oral

Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1

If inhaled

Following skin contact

Following eye contact

Following ingestion

SYMPTOMS: Symptoms of exposure to this compound include central nervous system stimulation, vomiting, diarrhea, paresthesia, excitement, giddiness, fatigue, tremors, convulsions, pulmonary edema, hypothermia, headache, loss of appetite muscular weakness, apprehensive mental state, myocardial toxicity, impotence, infertility and coma. It may also cause hyperexcitability, narcosis, central nervous system depression, kidney damage and liver damage. Other symptoms include muscle pains, ataxia, mild delirium and fever. It may also cause skin irritation. Testicular damage can occur. ACUTE/CHRONIC HAZARDS: This compound is moderately toxic by inhalation. It may be absorbed through the respiratory tract, gastrointestinal tract and skin. It may cause irritation of the skin. When heated to decomposition it emits toxic fumes of chlorides. (NTP, 1992)

Flash point data for this chemical are not available; however, it is probably combustible. (NTP, 1992)

Use water spray, powder, foam, carbon dioxide.

Personal protection: P2 filter respirator for harmful particles. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.

Personal protection: P2 filter respirator for harmful particles. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.

SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a POTW is acceptable only after review by the governing authority. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must meet Hazardous Material Criteria for disposal.

NO open flames. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Separated from food and feedstuffs, strong oxidants, bases and strong acids.PRECAUTIONS FOR "CARCINOGENS": Storage site should be as close as practicable to lab in which carcinogens are to be used, so that only small quantities required for ... expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion-proof refrigerator or freezer (depending on chemicophysical properties ...) that bears appropriate label. An inventory ... should be kept, showing quantity of carcinogen & date it was acquired ... Facilities for dispensing ... should be contiguous to storage area. Chemical Carcinogens

Occupational Exposure limit values

Biological limit values

Eye/face protection

Skin protection

Respiratory protection

Thermal hazards

Decomposes on heating. This produces toxic and corrosive fumes. Reacts with strong acids, bases and strong oxidants. This generates fire hazard.

no data available

This chemical may burn but does not easily ignite.CHLOROBENZILATE is hydrolyzed by alkalis and strong acids. Incompatible with lime (NTP, 1992).

no data available

Strong acids , strong bases, lime.

Emits toxic fumes of /hydrogen chloride/ when heated to decomposition.

Acute toxicity

• Oral: LD50 Rat oral 2784-3880 mg/kg
• Inhalation: no data available
• Dermal: LD50 Rabbit percutaneous >10,000 mg/kg

Skin corrosion/irritation

Serious eye damage/irritation

Respiratory or skin sensitization

Germ cell mutagenicity

Carcinogenicity

Reproductive toxicity

STOT-single exposure

STOT-repeated exposure

Aspiration hazard

• Toxicity to fish: LC50; Species: Oncorhynchus mykiss (Rainbow trout, weight 0.8g); Conditions: freshwater, static, 13 deg C, pH 7.1, hardness 44 mg/L CaCO3; Concentration: 750 ug/L for 24 hr /95.5% purity, technical material
• Toxicity to daphnia and other aquatic invertebrates: no data available
• Toxicity to algae: no data available
• Toxicity to microorganisms: no data available

AEROBIC: The rate at which chlorobenzilate degrades in microbial growth media increases when citrate is incorporated(1). This may be due to a reductive decarboxylation process that the citrate stimulates(1). The half-life of chlorobenzilate in two fine sandy soils was estimated to be 1.5-5 weeks following application of 0.5-1.0 ppm; removal was probably microbial(2). It is decarboxylated to 4,4'-dichlorobenzophenone by a yeast isolated from insecticide treated soil under anaerobic conditions(3,4). In 22 days, 40, 29, and 39% of the (14)C-ring-labeled chlorobenzilate added to sediment-free water samples from 3 fresh water lakes was converted to organic products; no (14)CO2 evolution was detected(5). Addition of sediment to the water samples from the three lakes gave (14)CO2 yields 3.6, 0.0, and 18.3%(5). Chlorobenzilate was metabolized in water from another freshwater lake only when glucose and inorganic nutrients were added and mineralized to (14)CO2 only when sediment was also added to the water(5). Chlorobenzilate, present at 100 mg/L, reached 0% of its theoretical BOD in 4 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test(6). Half-lives for chlorobenzilate in Lukang silty clay loam and Pincheng clay ranged from 15.1 days at 10 deg C to 10.8 days at 25 deg C; and 169.1 days at 10 deg C to 29.5 days at 25 deg C, respectively(7).

Measured BCF values for carp (Cyprinus carpio) ranged from 224 to 586 and 256 to 709 at concentrations of 20 ug/L and 2 ug/L, respectively(1). According to a classification scheme(2), these BCFs suggest the potential for bioconcentration in aquatic organisms is high(SRC).

The Koc of chlorobenzilate is estimated as 1,500(SRC), using a log Kow of 4.74(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that chlorobenzilate is expected to have low mobility in soil. Kd values of 26 and 7.6 have been reported for Lukang and Pincheng soils, respectively, at 20 deg C; at 40 deg C, the Kd values reported were 41 and 5.3, respectively(4).

no data available

Product

Contaminated packaging

no data available

no data available

Information on revision

Abbreviations and acronyms

• CAS: Chemical Abstracts Service
• ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
• RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
• IMDG: International Maritime Dangerous Goods
• IATA: International Air Transportation Association
• TWA: Time Weighted Average
• STEL: Short term exposure limit
• LC50: Lethal Concentration 50%
• LD50: Lethal Dose 50%
• EC50: Effective Concentration 50%

References

• IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
• HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
• IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
• eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
• CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
• ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
• ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
• Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
• ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Other Information

The substance is combustible but no flash point is available in literature.Carrier solvents used in commercial formulations may change physical and toxicological properties.Insufficient data are available on the effect of this substance on human health, therefore utmost care must be taken.