β-Hexachlorocyclohexane Safety Data Sheets
SAFETY DATA SHEETS
According to the UN GHS revision 8
SECTION 1: Identification
1.1 GHS Product identifier
| Product name | (1α,2β,3α,4β,5α,6β)-1,2,3,4,5,6-hexachlorocyclohexane |
|---|
1.2 Other means of identification
| Product number | - |
|---|---|
| Other names | betaisomer; beta-hexachlorocyclohexane; B-BHC |
1.3 Recommended use of the chemical and restrictions on use
| Identified uses | Lindane is used as an insecticide on fruit and vegetable crops, for seed treatment, in forestry, and for livestock and pet treatment. Lindane is no longer produced in the United States (however, it is still formulated in this country), and aerial application of the chemical is prohibited. Lindane is also used topically for the treatment of head and body lice and scabies; it is available in 1 percent preparations as a lotion, cream, or shampoo. |
|---|---|
| Uses advised against | no data available |
1.4 Supplier's details
| Company | Echemi.com |
|---|---|
| Address | Echemi.com |
| Telephone | Echemi.com |
1.5 Emergency phone number
| Emergency phone number | Echemi.com |
|---|---|
| Service hours | Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours). |
SECTION 2: Hazard identification
2.1 Classification of the substance or mixture
Acute toxicity - Category 3, Oral
Acute toxicity - Category 4, Dermal
Carcinogenicity, Category 2
Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1
Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1
2.2 GHS label elements, including precautionary statements
| Pictogram(s) |    |
|---|---|
| Signal word | Danger |
| Hazard statement(s) | H301 Toxic if swallowed H312 Harmful in contact with skin H351 Suspected of causing cancer H400 Very toxic to aquatic life H410 Very toxic to aquatic life with long lasting effects |
| Precautionary statement(s) | |
| Prevention | P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P203 Obtain, read and follow all safety instructions before use. P273 Avoid release to the environment. |
| Response | P301+P316 IF SWALLOWED: Get emergency medical help immediately. P321 Specific treatment (see ... on this label). P330 Rinse mouth. P302+P352 IF ON SKIN: Wash with plenty of water/... P317 Get medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P318 IF exposed or concerned, get medical advice. P391 Collect spillage. |
| Storage | P405 Store locked up. |
| Disposal | P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal. |
2.3 Other hazards which do not result in classification
no data available
SECTION 3: Composition/information on ingredients
3.1 Substances
| Chemical name | Common names and synonyms | CAS number | EC number | Concentration |
|---|---|---|---|---|
| (1α,2β,3α,4β,5α,6β)-1,2,3,4,5,6-hexachlorocyclohexane | (1α,2β,3α,4β,5α,6β)-1,2,3,4,5,6-hexachlorocyclohexane | 319-85-7 | 206-271-3 | 100% |
SECTION 4: First-aid measures
4.1 Description of necessary first-aid measures
If inhaled
Fresh air, rest. Seek medical attention if you feel unwell.
Following skin contact
Wear protective gloves when administering first aid. Remove contaminated clothes. Rinse and then wash skin with water and soap. Seek medical attention if you feel unwell.
Following eye contact
Rinse with plenty of water (remove contact lenses if easily possible).
Following ingestion
Rinse mouth. Give a slurry of activated charcoal in water to drink, but NOT if convulsions occur. Refer immediately for medical attention.
4.2 Most important symptoms/effects, acute and delayed
ACUTE/CHRONIC HAZARDS: Highly toxic. May cause irritation on contact. Hazardous decomposition products. (NTP, 1992)
Excerpt from ERG Guide 151 [Substances - Toxic (Non-combustible)]: Highly toxic, may be fatal if inhaled, swallowed or absorbed through skin. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution. (ERG, 2016)
ACUTE/CHRONIC HAZARDS: Highly toxic carcinogen. May cause irritation on contact. Hazardous decomposition products. (NTP, 1992)
Lindane is a stimulant of the nervous system, causing violent convulsions that are rapid in onset and generally followed by death or recovery within 24 hours. The probable human oral lethal dose is 50-500 mg/kg, or between 1 teaspoon and 1 ounce for a 150-lb (70 kg) person. (EPA, 1998)
ACUTE/CHRONIC HAZARDS: Carcinogen. Toxic. Irritant. Hazardous decomposition product. (NTP, 1992)
4.3 Indication of immediate medical attention and special treatment needed, if necessary
Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary . Anticipate seizures and treat if necessary . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal . Lindane and Related Compounds
SECTION 5: Fire-fighting measures
5.1 Suitable extinguishing media
This compound is not very flammable but any fire involving this compound may produce dangerous vapors. You should evacuate the area. All firefighters should wear full-body protective clothing and use self-contained breathing apparatuses. You should extinguish any fires involving this chemical with a dry chemical, carbon dioxide, foam, or halon extinguisher. (NTP, 1992)
5.2 Specific hazards arising from the chemical
Excerpt from ERG Guide 151 [Substances - Toxic (Non-combustible)]: Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Containers may explode when heated. Runoff may pollute waterways. (ERG, 2016)
Excerpt from ERG Guide 151 [Substances - Toxic (Non-combustible)]: Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Containers may explode when heated. Runoff may pollute waterways. (ERG, 2016)
Excerpt from ERG Guide 151 [Substances - Toxic (Non-combustible)]: Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Containers may explode when heated. Runoff may pollute waterways. (ERG, 2016)
When heated to decomposition, this compound emits toxic fumes of chlorine, hydrochloric acid, and phosgene. (EPA, 1998)
Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]: Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.). Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. For electric vehicles or equipment, ERG Guide 147 (lithium ion batteries) or ERG Guide 138 (sodium batteries) should also be consulted. (ERG, 2016)
5.3 Special protective actions for fire-fighters
In case of fire in the surroundings, use appropriate extinguishing media. In case of fire: keep drums, etc., cool by spraying with water.
SECTION 6: Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures
Personal protection: filter respirator for organic gases and particulates adapted to the airborne concentration of the substance, chemical protection suit including self-contained breathing apparatus and protective gloves. Do NOT let this chemical enter the environment. Sweep spilled substance into sealable non-metallic containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.
6.2 Environmental precautions
Personal protection: filter respirator for organic gases and particulates adapted to the airborne concentration of the substance, chemical protection suit including self-contained breathing apparatus and protective gloves. Do NOT let this chemical enter the environment. Sweep spilled substance into sealable non-metallic containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.
6.3 Methods and materials for containment and cleaning up
Liquids containing lindane should be absorbed in vermiculite, dry sand, earth, or a similar material. Lindane
SECTION 7: Handling and storage
7.1 Precautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
7.2 Conditions for safe storage, including any incompatibilities
Well closed. Store in an area without drain or sewer access. Provision to contain effluent from fire extinguishing. Separated from bases, metals and food and feedstuffs.Store in dry place. ... avoid exposure ... to extreme heat, strong alkalis, and powdered metals.
SECTION 8: Exposure controls/personal protection
8.1 Control parameters
Occupational Exposure limit values
MAK: (inhalable fraction): 0.1 mg/m3; peak limitation category: II(8); skin absorption (H); carcinogen category: 4; pregnancy risk group: D
Biological limit values
no data available
8.2 Appropriate engineering controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
8.3 Individual protection measures, such as personal protective equipment (PPE)
Eye/face protection
Wear face shield or eye protection in combination with breathing protection if powder.
Skin protection
Protective gloves. Protective clothing.
Respiratory protection
Avoid inhalation of dust.
Thermal hazards
no data available
SECTION 9: Physical and chemical properties and safety characteristics
| Physical state | PHYSICAL DESCRIPTION: Slightly musty odor. (NTP, 1992) |
|---|---|
| Colour | Crystals from benzene, alcohol, or xylene |
| Odour | Slight musty odor |
| Melting point/freezing point | â¥300ºC |
| Boiling point or initial boiling point and boiling range | 288ºC at 760mmHg |
| Flammability | Noncombustible Solid, but may be dissolved in flammable liquids. |
| Lower and upper explosion limit/flammability limit | no data available |
| Flash point | 157.5ºC |
| Auto-ignition temperature | Not flammable (USCG, 1999) |
| Decomposition temperature | no data available |
| pH | no data available |
| Kinematic viscosity | no data available |
| Solubility | less than 1 mg/mL at 75° F (NTP, 1992) |
| Partition coefficient n-octanol/water | 3.8 |
| Vapour pressure | 0.14 mm Hg at 104° F (NTP, 1992) |
| Density and/or relative density | 1.59g/cm3 |
| Relative vapour density | (air = 1): 10 |
| Particle characteristics | no data available |
SECTION 10: Stability and reactivity
10.1 Reactivity
Decomposes on contact with hot surfaces or flames. This produces toxic and corrosive fumes including chlorine (see ICSC 0126), hydrogen chloride (see ICSC 0163) and phosgene (see ICSC 0007). Reacts with bases and powdered metals.
Decomposes on heating and on burning. This produces toxic and corrosive fumes including chlorine (see ICSC 0126), hydrogen chloride (see ICSC 0163) and phosgene (see ICSC 0007). Reacts with bases. This produces toxic and corrosive fumes including hydrogen chloride and trichlorobenzenes (see ICSCs 0344, 1049 and 1222).
Decomposes on contact with hot surfaces or flames. This produces toxic and corrosive fumes including chlorine (see ICSC 0126), hydrogen chloride (see ICSC 0163) and phosgene (see ICSC 0007). Reacts with bases and powdered metals.
Decomposes on contact with hot surfaces or flames. This produces toxic and corrosive fumes including chlorine (see ICSC 0126), hydrogen chloride (see ICSC 0163) and phosgene (see ICSC 0007). Reacts with bases and powdered metals.
10.2 Chemical stability
Considerable stability in acids, unstable in alkaline condition. from table
10.3 Possibility of hazardous reactions
Not flammable.DELTA-BHC may be incompatible with strong oxidizing and reducing agents. Incompatible with some amines, nitrides, azo/diazo compounds, with alkali metals, and with epoxides.
10.4 Conditions to avoid
no data available
10.5 Incompatible materials
Incompatible with alkaline materials.
10.6 Hazardous decomposition products
When heated to decomposition it emits toxic fumes of /hydrogen chloride, HCl, and phosgene/.
SECTION 11: Toxicological information
Acute toxicity
- Oral: LD50 Rat oral 6 g/kg
- Inhalation: LC50 Rat inhalation 1.56 mg/L
- Dermal: no data available
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
CLASSIFICATION: C; possible human carcinogen. BASIS FOR CLASSIFICATION: Increases in benign liver tumors in CF1 mice fed beta-HCH. HUMAN CARCINOGENICITY DATA: Inadequate.
Reproductive toxicity
Limited information is available regarding the reproductive or developmental effects of lindane in humans. The one available study reported increased levels (not statistically significant) of follicle stimulating hormone and decreased levels of testosterone in men occupationally exposed to lindane. It is not known whether these hormonal changes could result in diminished reproductive capability. Animal studies have reported reproductive effects, such as decreased sperm count, increased testicular weight, and disruption of spermatogenesis from oral exposure to lindane. Disrupted ovarian cycling and reduced ovulation rate were reported in female animals exposed to lindane by gavage (experimentally placing the chemical in the stomach). Lindane has not been reported to cause developmental effects, such as birth defects, in animals via oral exposure.
STOT-single exposure
The substance may cause effects on the central nervous system. This may result in convulsions.
STOT-repeated exposure
The substance may have effects on the central nervous system, liver and kidney. This substance is possibly carcinogenic to humans. Animal tests show that this substance possibly causes toxic effects upon human reproduction.
Aspiration hazard
A harmful concentration of airborne particles can be reached quickly when dispersed.
SECTION 12: Ecological information
12.1 Toxicity
- Toxicity to fish: LC50 Danio rerio (Zebra danio) 1780 ug/L/24 hr (95% confidence limit: 1320-3590 ug/L); static /formulated product
- Toxicity to daphnia and other aquatic invertebrates: LC50 Daphnia magna (Water flea) 1.64 mg/L/24 hr (95% confidence limit: 1.15-1.78 mg/L); static
- Toxicity to algae: no data available
- Toxicity to microorganisms: no data available
12.2 Persistence and degradability
AEROBIC: beta-Hexachlorocyclohexane is expected to be recalcitrant under aerobic conditions(SRC). No biodegradation of beta-hexachlorocyclohexane was observed in contaminated soil from Hengelo, Netherlands over a 100 day incubation period(1). No biodegradation of beta-hexachlorocyclohexane was observed in contaminated moist soils or slurries over a 40 week incubation period(2) and no biodegradation of beta-hexachlorocyclohexane was observed in hexachlorocyclohexane contaminated moist soils or slurries over a 23 week incubation period(3). Approximately 30 percent biodegradation was observed for beta-hexachlorocyclohexane after 570 days in a field test in Japan using agricultural plots(4). The half-life of beta-hexachlorocyclohexane on cropped and uncropped soils was reported as 184 and 100 days, respectively(5). Pure cultures of Pseudomonas sp, isolated from sugarcane soil, completely biodegraded beta-hexachlorocyclohexane under aerobic conditions in 72 hours(6).
12.3 Bioaccumulative potential
An avg log BCF of 2.8 (BCF = 631) was reported for beta-hexachlorocyclohexane(SRC) in various fish in a flowing water simulator(1). According to a classification scheme(2), this BCF value suggests that bioconcentration in aquatic organisms is high(SRC).
12.4 Mobility in soil
Experimentally determined log Koc values of 3.4-4.1 were reported in 2 oil contaminated soils(1). According to a classification scheme(2), these Koc values suggest that beta-hexachlorocyclohexane is expected to have low mobility in soil(SRC).
12.5 Other adverse effects
no data available
SECTION 13: Disposal considerations
13.1 Disposal methods
Product
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Contaminated packaging
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
SECTION 14: Transport information
14.1 UN Number
| ADR/RID: UN1230 (For reference only, please check.) | IMDG: UN1230 (For reference only, please check.) | IATA: UN1230 (For reference only, please check.) |
14.2 UN Proper Shipping Name
| ADR/RID: METHANOL (For reference only, please check.) | IMDG: METHANOL (For reference only, please check.) | IATA: METHANOL (For reference only, please check.) |
14.3 Transport hazard class(es)
| ADR/RID: 3 (For reference only, please check.) | IMDG: 3 (For reference only, please check.) | IATA: 3 (For reference only, please check.) |
14.4 Packing group, if applicable
| ADR/RID: II (For reference only, please check.) | IMDG: II (For reference only, please check.) | IATA: II (For reference only, please check.) |
14.5 Environmental hazards
| ADR/RID: Yes | IMDG: Yes | IATA: Yes |
14.6 Special precautions for user
no data available
14.7 Transport in bulk according to IMO instruments
no data available
SECTION 15: Regulatory information
15.1 Safety, health and environmental regulations specific for the product in question
| Chemical name | Common names and synonyms | CAS number | EC number |
|---|---|---|---|
| (1α,2β,3α,4β,5α,6β)-1,2,3,4,5,6-hexachlorocyclohexane | (1α,2β,3α,4β,5α,6β)-1,2,3,4,5,6-hexachlorocyclohexane | 319-85-7 | 206-271-3 |
| European Inventory of Existing Commercial Chemical Substances (EINECS) | Listed. | ||
| EC Inventory | Listed. | ||
| United States Toxic Substances Control Act (TSCA) Inventory | Listed. | ||
| China Catalog of Hazardous chemicals 2015 | Listed. | ||
| New Zealand Inventory of Chemicals (NZIoC) | Not Listed. | ||
| Philippines Inventory of Chemicals and Chemical Substances (PICCS) | Not Listed. | ||
| Vietnam National Chemical Inventory | Not Listed. | ||
| Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) | Listed. | ||
| Korea Existing Chemicals List (KECL) | Not Listed. | ||
SECTION 16: Other information
Information on revision
| Creation Date | July 15, 2019 |
|---|---|
| Revision Date | July 15, 2019 |
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
Other Information
This substance is a component of the insecticide hexachlorocyclohexane (isomer mixture).Carrier solvents used in commercial formulations may change physical and toxicological properties.Do NOT take working clothes home.Do NOT use in the vicinity of a fire or a hot surface, or during welding.Occupational Exposure Limits : MAK value is for technical mixture of alpha and beta isomers (0.5 mg/m³=(Conc.alpha-HCH divided by 5) + Conc beta-HCH))See ICSCs 0053, 0487 and 0795.
Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.
β-Hexachlorocyclohexane is included in Insecticides category.
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