Phenyl glycidyl ether Safety Data Sheets
SAFETY DATA SHEETS
According to the UN GHS revision 8
SECTION 1: Identification
1.1 GHS Product identifier
| Product name | 2,3-epoxypropyl phenyl ether |
|---|
1.2 Other means of identification
| Product number | - |
|---|---|
| Other names | Glycidyl Phenyl Ether; 2-(phenoxymethyl)oxirane; Oxirane, (phenoxymethyl)- |
1.3 Recommended use of the chemical and restrictions on use
| Identified uses | Process regulators |
|---|---|
| Uses advised against | no data available |
1.4 Supplier's details
| Company | Echemi.com |
|---|---|
| Address | Echemi.com |
| Telephone | Echemi.com |
1.5 Emergency phone number
| Emergency phone number | Echemi.com |
|---|---|
| Service hours | Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours). |
SECTION 2: Hazard identification
2.1 Classification of the substance or mixture
Skin irritation, Category 2
Skin sensitization, Category 1
Acute toxicity - Category 4, Inhalation
Specific target organ toxicity â single exposure, Category 3
Germ cell mutagenicity, Category 2
Carcinogenicity, Category 1B
Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 3
2.2 GHS label elements, including precautionary statements
| Pictogram(s) |   |
|---|---|
| Signal word | Danger |
| Hazard statement(s) | H315 Causes skin irritation H317 May cause an allergic skin reaction H332 Harmful if inhaled H335 May cause respiratory irritation H341 Suspected of causing genetic defects H350 May cause cancer H412 Harmful to aquatic life with long lasting effects |
| Precautionary statement(s) | |
| Prevention | P264 Wash ... thoroughly after handling. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P272 Contaminated work clothing should not be allowed out of the workplace. P271 Use only outdoors or in a well-ventilated area. P203 Obtain, read and follow all safety instructions before use. P273 Avoid release to the environment. |
| Response | P302+P352 IF ON SKIN: Wash with plenty of water/... P321 Specific treatment (see ... on this label). P332+P317 If skin irritation occurs: Get medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P333+P317 If skin irritation or rash occurs: Get medical help. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P317 Get medical help. P319 Get medical help if you feel unwell. P318 IF exposed or concerned, get medical advice. |
| Storage | P403+P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up. |
| Disposal | P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal. |
2.3 Other hazards which do not result in classification
no data available
SECTION 3: Composition/information on ingredients
3.1 Substances
| Chemical name | Common names and synonyms | CAS number | EC number | Concentration |
|---|---|---|---|---|
| 2,3-epoxypropyl phenyl ether | 2,3-epoxypropyl phenyl ether | 122-60-1 | 204-557-2 | 100% |
SECTION 4: First-aid measures
4.1 Description of necessary first-aid measures
If inhaled
Fresh air, rest.
Following skin contact
Remove contaminated clothes. Rinse and then wash skin with water and soap.
Following eye contact
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Following ingestion
Rinse mouth.
4.2 Most important symptoms/effects, acute and delayed
Exposure Routes: inhalation, skin absorption, ingestion, skin and/or eye contact Symptoms: Irritation eyes, skin; upper respiratory system; skin sensitization; narcosis; possible hematopoietic, reproductive effects; [potential occupational carcinogen] Target Organs: Eyes, skin, central nervous system, hematopoietic system, reproductive system (NIOSH, 2016)
4.3 Indication of immediate medical attention and special treatment needed, if necessary
Absorption, Distribution and Excretion
Phenyl glycidyl ether percutaneous absorption rates were 13.5 mg/sq cm/hr in rats & 4.2 mg/sq cm/hr for rabbits.
SECTION 5: Fire-fighting measures
5.1 Suitable extinguishing media
Dry chemical, carbon dioxide, or alcohol foam.
5.2 Specific hazards arising from the chemical
This chemical is probably combustible. (NTP, 1992)
5.3 Special protective actions for fire-fighters
Use water spray, foam, powder, carbon dioxide.
SECTION 6: Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures
Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Collect leaking and spilled liquid in covered containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.
6.2 Environmental precautions
Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Collect leaking and spilled liquid in covered containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.
6.3 Methods and materials for containment and cleaning up
Do NOT let this chemical enter the environment. Collect leaking liquid in covered containers. Absorb remaining liquid in sand or inert absorbent and remove to safe place.
SECTION 7: Handling and storage
7.1 Precautions for safe handling
NO open flames. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
7.2 Conditions for safe storage, including any incompatibilities
Store in an area without drain or sewer access. Separated from strong oxidants, strong bases, strong acids and amines. Cool. Keep in the dark.Store in an area without drain or sewer access. Seperated from strong oxidants, strong bases, strong acids and amines. Cool. Keep in the dark.
SECTION 8: Exposure controls/personal protection
8.1 Control parameters
Occupational Exposure limit values
TLV: 0.1 ppm as TWA; (skin); (SEN); A3 (confirmed animal carcinogen with unknown relevance to humans).MAK: skin absorption (H); sensitization of skin (SH); carcinogen category: 2
Biological limit values
no data available
8.2 Appropriate engineering controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
8.3 Individual protection measures, such as personal protective equipment (PPE)
Eye/face protection
Wear safety goggles or eye protection in combination with breathing protection.
Skin protection
Protective gloves. Protective clothing.
Respiratory protection
Use ventilation, local exhaust or breathing protection.
Thermal hazards
no data available
SECTION 9: Physical and chemical properties and safety characteristics
| Physical state | Liquid. |
|---|---|
| Colour | Colorless. |
| Odour | no data available |
| Melting point/freezing point | 3.5 °C. |
| Boiling point or initial boiling point and boiling range | 245 °C. |
| Flammability | Class IIIB Combustible Liquid: Fl.P. at or above 200°F. |
| Lower and upper explosion limit/flammability limit | Combustible |
| Flash point | 120 °C. |
| Auto-ignition temperature | 430 °C. |
| Decomposition temperature | no data available |
| pH | no data available |
| Kinematic viscosity | no data available |
| Solubility | 1 to 5 mg/mL at 64° F (NTP, 1992) |
| Partition coefficient n-octanol/water | log Pow = 1.61. Temperature:25 °C. |
| Vapour pressure | 0.013 hPa. Temperature:25 °C. |
| Density and/or relative density | 1.111. Temperature:21 °C. |
| Relative vapour density | 5.2 (vs air) |
| Particle characteristics | no data available |
SECTION 10: Stability and reactivity
10.1 Reactivity
100 ppm; NIOSH considers phenyl glycidyl ether to be a potential occupational carcinogen.
The substance can presumably form explosive peroxides. The substance polymerizes under the influence of acids, bases and amines. Reacts violently with strong oxidants. This generates fire and explosion hazard.
10.2 Chemical stability
no data available
10.3 Possibility of hazardous reactions
PHENYL GLYCIDYL ETHER, an ether, can act as a base. They form salts with strong acids and addition complexes with Lewis acids. The complex between diethyl ether and boron trifluoride is an example. Ethers may react violently with strong oxidizing agents. In other reactions, which typically involve the breaking of the carbon-oxygen bond, ethers are relatively inert.
10.4 Conditions to avoid
no data available
10.5 Incompatible materials
Incompatibilities: Contact with strong oxidizing agents may cause fires and explosions. Contact with amines, strong acids, and strong bases may cause polymerization with the liberation of heat and spattering. Exposure to light and air may result in the formation of explosive peroxides.
10.6 Hazardous decomposition products
Energy of decomposition (in range 360-450 deg C) measured as 0.626 kJ/g.
SECTION 11: Toxicological information
Acute toxicity
- Oral: LD50 - rat - 4 260 mg/kg bw.
- Inhalation: LC100 - rat (male) - 323 ppm.
- Dermal: LD50 - rabbit (male) - 1 666 mg/kg bw.
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
Evaluation: No epidemiological data relevant to the carcinogenicity of phenyl glycidyl ether were available. There is sufficient evidence in experimental animals for the carcinogenicity of phenyl glycidyl ether. Overall evaluation: Phenyl glycidyl ether is possibly carcinogenic to humans (Group 2B).
Reproductive toxicity
no data available
STOT-single exposure
The substance is irritating to the eyes, skin and respiratory tract.
STOT-repeated exposure
Repeated or prolonged contact may cause skin sensitization. This substance is possibly carcinogenic to humans.
Aspiration hazard
A harmful contamination of the air will be reached rather slowly on evaporation of this substance at 20°C; on spraying or dispersing, however, much faster.
SECTION 12: Ecological information
12.1 Toxicity
- Toxicity to fish: LC50 - Carassius auratus - 43 mg/L - 96 h.
- Toxicity to daphnia and other aquatic invertebrates: no data available
- Toxicity to algae: no data available
- Toxicity to microorganisms: no data available
12.2 Persistence and degradability
AEROBIC: A 5-day theoretical BOD of 6% was measured for phenyl glycidyl ether using a standard dilution method and an effluent from a biological sanitary waste treatment plant as the inoculum(1). A 5-day theoretical BOD of 0% was measured using a BOD dilution method and an acclimated sewage inoculum(2). Phenyl glycidyl ether, present at 100 mg/L, reached 33% of its theoretical BOD in 4 weeks using an activated sludge inoculum at 30 mg/L and the Japanese MITI test(3).
12.3 Bioaccumulative potential
An estimated BCF of 8 was calculated for phenyl glycidyl ether(SRC), using a water solubility of 2,400 mg/L(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).
12.4 Mobility in soil
The Koc of phenyl glycidyl ether is estimated as 60(SRC), using a water solubility of 2,400 mg/L(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that phenyl glycidyl ether is expected to have high mobility in soil.
12.5 Other adverse effects
no data available
SECTION 13: Disposal considerations
13.1 Disposal methods
Product
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Contaminated packaging
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
SECTION 14: Transport information
14.1 UN Number
| ADR/RID: Not dangerous goods. (For reference only, please check.) | IMDG: Not dangerous goods. (For reference only, please check.) | IATA: Not dangerous goods. (For reference only, please check.) |
14.2 UN Proper Shipping Name
| ADR/RID: Not dangerous goods. (For reference only, please check.) | IMDG: Not dangerous goods. (For reference only, please check.) | IATA: Not dangerous goods. (For reference only, please check.) |
14.3 Transport hazard class(es)
| ADR/RID: Not dangerous goods. (For reference only, please check.) | IMDG: Not dangerous goods. (For reference only, please check.) | IATA: Not dangerous goods. (For reference only, please check.) |
14.4 Packing group, if applicable
| ADR/RID: Not dangerous goods. (For reference only, please check.) | IMDG: Not dangerous goods. (For reference only, please check.) | IATA: Not dangerous goods. (For reference only, please check.) |
14.5 Environmental hazards
| ADR/RID: No | IMDG: No | IATA: No |
14.6 Special precautions for user
no data available
14.7 Transport in bulk according to IMO instruments
no data available
SECTION 15: Regulatory information
15.1 Safety, health and environmental regulations specific for the product in question
| Chemical name | Common names and synonyms | CAS number | EC number |
|---|---|---|---|
| 2,3-epoxypropyl phenyl ether | 2,3-epoxypropyl phenyl ether | 122-60-1 | 204-557-2 |
| European Inventory of Existing Commercial Chemical Substances (EINECS) | Listed. | ||
| EC Inventory | Listed. | ||
| United States Toxic Substances Control Act (TSCA) Inventory | Listed. | ||
| China Catalog of Hazardous chemicals 2015 | Listed. | ||
| New Zealand Inventory of Chemicals (NZIoC) | Listed. | ||
| Philippines Inventory of Chemicals and Chemical Substances (PICCS) | Listed. | ||
| Vietnam National Chemical Inventory | Listed. | ||
| Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) | Listed. | ||
| Korea Existing Chemicals List (KECL) | Listed. | ||
SECTION 16: Other information
Information on revision
| Creation Date | July 15, 2019 |
|---|---|
| Revision Date | July 15, 2019 |
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
Other Information
Do NOT take working clothes home.Check for peroxides prior to distillation; eliminate if found.
Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.
Phenyl glycidyl ether is included in Nitrogen Compounds category.
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