Nitrofen Safety Data Sheets

Acute toxicity - Category 4, Oral

Carcinogenicity, Category 1B

Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1

Reproductive toxicity, Category 1B

If inhaled

Following skin contact

Following eye contact

Following ingestion

SYMPTOMS: Symptoms of exposure to this compound may include irritation of the skin and eyes. ACUTE/CHRONIC HAZARDS: This compound is toxic by ingestion. It may cause irritation of the skin and eyes. When heated to decomposition it emits toxic fumes of nitrogen oxides and chlorine. (NTP, 1992)

Flash point data for this chemical are not available; however, it is probably combustible. (NTP, 1992)

Use water spray, powder, foam, carbon dioxide.

Sweep spilled substance into covered containers. Carefully collect remainder. Then store and dispose of according to local regulations. Do NOT let this chemical enter the environment. Personal protection: P3 filter respirator for toxic particles.

Sweep spilled substance into covered containers. Carefully collect remainder. Then store and dispose of according to local regulations. Do NOT let this chemical enter the environment. Personal protection: P3 filter respirator for toxic particles.

PRECAUTIONS FOR "CARCINOGENS": A high-efficiency particulate arrestor (HEPA) or charcoal filters can be used to minimize amt of carcinogen in exhausted air ventilated safety cabinets, lab hoods, glove boxes or animal rooms ... Filter housing that is designed so that used filters can be transferred into plastic bag without contaminating maintenance staff is avail commercially. Filters should be placed in plastic bags immediately after removal ... The plastic bag should be sealed immediately ... The sealed bag should be labelled properly ... Waste liquids ... should be placed or collected in proper containers for disposal. The lid should be secured & the bottles properly labelled. Once filled, bottles should be placed in plastic bag, so that outer surface ... is not contaminated ... The plastic bag should also be sealed & labelled. ... Broken glassware ... should be decontaminated by solvent extraction, by chemical destruction, or in specially designed incinerators. Chemical Carcinogens

NO open flames. Closed system, dust explosion-proof electrical equipment and lighting. Prevent deposition of dust. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Separated from food and feedstuffs. Well closed.PRECAUTIONS FOR "CARCINOGENS": Storage site should be as close as practical to lab in which carcinogens are to be used, so that only small quantities required for ... expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion-proof refrigerator or freezer (depending on chemicophysical properties ...) that bears appropriate label. An inventory ... should be kept, showing quantity of carcinogen & date it was acquired ... Facilities for dispensing ... should be contiguous to storage area. Chemical Carcinogens

Occupational Exposure limit values

Biological limit values

Eye/face protection

Skin protection

Respiratory protection

Thermal hazards

On combustion, forms toxic fumes.

Darkens under exposure to light

FLAMMABLEDust explosion possible if in powder or granular form, mixed with air.NITROFEN is a nitrated and halogenated ether derivative.

no data available

no data available

When heated to decomp it emits very toxic fumes of hydrogen chloride and nitrogen oxides.

Acute toxicity

• Oral: LD50 Rabbit oral 780 mg/kg bw
• Inhalation: LC50 Rat inhalation 205 mg/L /1 hr
• Dermal: no data available

Skin corrosion/irritation

Serious eye damage/irritation

Respiratory or skin sensitization

Germ cell mutagenicity

Carcinogenicity

Reproductive toxicity

STOT-single exposure

STOT-repeated exposure

Aspiration hazard

• Toxicity to fish: no data available
• Toxicity to daphnia and other aquatic invertebrates: no data available
• Toxicity to algae: EC50; Species: Scenedesmus subspicatus (Green Algae); Conditions: freshwater, static; Concentration: 1800 ug/L for 49-79 min, population decrease /100% purity formulation
• Toxicity to microorganisms: no data available

Nitrofen degraded slowly under aerobic and anaerobic conditions with a sewage inoculum, but only in the presence of an external source of carbon and energy; after 88 days of incubation 6% and 4% degradation occurred under aerobic and anaerobic conditions, respectively(1). Four unspecified products were formed in the aerobic experiment, all more hydrophilic than the parent compound(1). The corresponding amine was identified as a biodegradation product of nitrofen(2). Nitrofen, present at 100 mg/L, reached 2% of its theoretical BOD in 4 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test(3). Nitrofen was degraded slowly by soil microorganisms during the first week and persisted more than 4 weeks when it was the sole source of carbon(4). When other sources of carbon were added, degradation occurred in 3 weeks(4). After 16 weeks of incubation in laboratory experiments, 15 and 38% of the initial concentration (10 ppm) of nitrofen remained in sandy loam (0.7% organic matter, pH 7.0) and muck (36.7% organic matter, pH 7.0) soils, respectively, 94% and 82% nitrofen remained in the same soils that were sterilized(5). Nitrofen slowly but completely biodegraded to carbon dioxide in typical soils likely proceeding through diphenyl ether cleavage(6). In a river die-away test using Asahi River (Japan) water, 1% of the nitrofen remained after 50 days incubation at 20 deg C(7).

The BCF of nitrofen in orange-red killifish (Oryzias latipes), exposed for 10 weeks to 50 and 5.0 ug/L was 2900-5370 and 2720-4220, respectively(1). Nitrofen bioconcentrated in algae, snails, mosquito larvae, and fish in a 3-day model aquatic ecosystem; <20% of the herbicide was found as metabolites(2). A 33-day model terrestrial-aquatic ecosystem in which 1.29 kg/ha of nitrofen was injected into paddy sand containing rice seedlings(2). The BCFs for fish, mosquito larvae, snails, and algae in this experiment were 1550, 3190, 2770, and 405, respectively(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is very high(SRC), provided the compound is not metabolized by the organism(SRC).

Using a structure estimation method based on molecular connectivity indices(1), the Koc of nitrofen can be estimated to be 7,800(SRC). According to a classification scheme(2), this estimated Koc value suggests that nitrofen is expected to be immobile in soil(SRC). Results of soil thin layer chromatography tests showed that nitrofen is immobile in soil(3). Similarly results were obtained in column leaching studies with both Plainfield sand and muck soils and indicate that leaching of nitrofen from arable soils will be negligible(4). In field experiments in sandy loam, heavy clay, and silty clay soils, <5% of the applied nitrofen was recovered from the 5-10 cm soil level, indicating that minimal leaching had occurred(5).

no data available

Product

Contaminated packaging

no data available

no data available

Information on revision

Abbreviations and acronyms

• CAS: Chemical Abstracts Service
• ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
• RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
• IMDG: International Maritime Dangerous Goods
• IATA: International Air Transportation Association
• TWA: Time Weighted Average
• STEL: Short term exposure limit
• LC50: Lethal Concentration 50%
• LD50: Lethal Dose 50%
• EC50: Effective Concentration 50%

References

• IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
• HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
• IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
• eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
• CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
• ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
• ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
• Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
• ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Other Information

If the substance is formulated with solvent(s) also consult the card(s) (ICSC) of the solvent(s).Carrier solvents used in commercial formulations may change physical and toxicological properties.Do NOT take working clothes home.