Pyrethrins Safety Data Sheets

Acute toxicity - Category 4, Oral

Acute toxicity - Category 4, Dermal

Acute toxicity - Category 4, Inhalation

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1

If inhaled

Following skin contact

Following eye contact

Following ingestion

Exposure Routes: inhalation, ingestion, skin and/or eye contact Symptoms: Erythema, dermatitis, papules, pruritus, rhinorrhea (discharge of thin mucus); sneezing; asthma Target Organs: respiratory system, skin, central nervous system (NIOSH, 2016)

Excerpt from ERG Guide 171 [Substances (Low to Moderate Hazard)]: Some may burn but none ignite readily. Containers may explode when heated. Some may be transported hot. For UN3508, be aware of possible short circuiting as this product is transported in a charged state. (ERG, 2016)

Use water spray, powder, foam, carbon dioxide.

Personal protection: filter respirator for organic gases and particulates adapted to the airborne concentration of the substance. Ventilation. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

Personal protection: filter respirator for organic gases and particulates adapted to the airborne concentration of the substance. Ventilation. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

If pyrethrum is spilled, the following steps should be taken: 1) Ventilate area of spill. 2) For small quantities, sweep onto paper or other suitable material, place in an appropriate container and burn in a safe place (such as a fume hood). Large quantities may be reclaimed; however, if this is not practical, dissolve in a flammable solvent (such as alcohol) and atomize in a suitable combustion chamber.

NO open flames. NO contact with oxidizing agents. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Separated from strong oxidants and food and feedstuffs. Well closed. Provision to contain effluent from fire extinguishing.Pyrethrins with piperonyl butoxide topical preparations should be stored in well-closed containers at a temperature less than 40 deg C, preferably between 15-30 deg C. Pyrethrins

Occupational Exposure limit values

Biological limit values

Eye/face protection

Skin protection

Respiratory protection

Thermal hazards

Decomposes on heating. This produces smoke and irritating fumes. Reacts with strong oxidants. This generates fire and explosion hazard.

Pyrethrums are highly unstable in the presence of light, moisture, and air. Whole flowers decompose more slowly than ground flowers or dust. Stored powders lose about 20% of their potency in one year. The potency of the pyrethrums can best be preserved in sealed, lightproof containers kept at lower temperatures.

Combustible when exposed to heat or flame.PYRETHRINS decompose rapidly in base; may generate heat with caustic solutions. May also react with acids to liberate heat. Generate flammable hydrogen with alkali metals and hydrides.

no data available

Incompatible with lime and ordinary soaps because acids & alkalies speed up processes of hydrolysis. Pyrethrins

When heated to decomposition it emits acrid smoke and irritating fumes.

Acute toxicity

• Oral: LD50 Rat oral 584 to 900 mg/kg (irrespective of grade or solvent)
• Inhalation: LC50 Rat inhalation 3.4 mg/l/4 hr Pyrethrins
• Dermal: LD50 Rat percutaneous greater than 1500 mg/kg

Skin corrosion/irritation

Serious eye damage/irritation

Respiratory or skin sensitization

Germ cell mutagenicity

Carcinogenicity

Reproductive toxicity

STOT-single exposure

STOT-repeated exposure

Aspiration hazard

• Toxicity to fish: LC50; Species: Oncorhynchus mykiss (Rainbow Trout) length 33 mm (30-38 mm), weight 0.3 g (0.2-0.4 g); Conditions: freshwater, static, 13 deg C, pH 7.1, alkalinity 35 mg/L CaCO3; Concentration: 56 ug/L for 24 hr (95% confidence interval: 49-64 ug/L) /24.6% pyrethrum formulation
• Toxicity to daphnia and other aquatic invertebrates: EC50; Species: Daphnia magna (Water Flea) age < or =24 hr; Conditions: freshwater, flow through; Concentration: 11.6 ug/L for 48 hr (95% confidence interval: 9.6-14.2 ug/L); Effect: intoxication, immobilization /57.49% purity
• Toxicity to algae: no data available
• Toxicity to microorganisms: no data available

AEROBIC: Pyrethrum is a mixture of pyrethrin compounds and specific biodegradation data are not available(SRC). However, the pyrethrin class of insecticides is degraded readily by ambient microorganisms; therefore, pyrethrum is expected to biodegrade readily(1,2).

An estimated BCF of 290 was calculated in fish for pyrethrum(SRC), using an estimated log Kow of 6.15(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is high(SRC).

Using a structure estimation method based on molecular connectivity indices(1), the Koc of pyrethrum can be estimated to be 10,000(SRC). According to a classification scheme(2), this estimated Koc value suggests that pyrethrum is expected to be immobile in soil.

no data available

Product

Contaminated packaging

no data available

no data available

Information on revision

Abbreviations and acronyms

• CAS: Chemical Abstracts Service
• ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
• RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
• IMDG: International Maritime Dangerous Goods
• IATA: International Air Transportation Association
• TWA: Time Weighted Average
• STEL: Short term exposure limit
• LC50: Lethal Concentration 50%
• LD50: Lethal Dose 50%
• EC50: Effective Concentration 50%

References

• IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
• HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
• IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
• eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
• CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
• ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
• ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
• Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
• ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Other Information

Pyrethrum is a mixture of pyrethrin I and II, cinerin I and II, and jasmolin I and II.Carrier solvents used in commercial formulations may change physical and toxicological properties.Do NOT take working clothes home.Anyone who has shown symptoms of asthma due to this substance should avoid all further contact.The symptoms of asthma often do not become manifest until a few hours have passed and they are aggravated by physical effort.Rest and medical observation are therefore essential.Immediate administration of an appropriate inhalation therapy by a doctor or a person authorized by him/her, should be considered.