Toluene 2,4-diisocyanate Safety Data Sheets

Skin irritation, Category 2

Eye irritation, Category 2

Skin sensitization, Category 1

Acute toxicity - Category 2, Inhalation

Specific target organ toxicity – single exposure, Category 3

Respiratory sensitization, Category 1

Carcinogenicity, Category 2

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 3

If inhaled

Following skin contact

Following eye contact

Following ingestion

Can cause death. Contact with skin may cause allergic eczema. Substance is very corrosive to eyes. Chronic exposure may cause chronic lung disease. As a vapor TDI is a powerful irritant to the respiratory tract. Chronic loss of respiratory function may occur. Acute asthmatic bronchitis or frank asthma may occur. A splash in the eyes of workmen has caused keratitis and conjunctivitis. This compound causes inflammation of the skin, also chemical pneumonitis and pulmonary edema. (EPA, 1998)

When heated to decomposition it emits very toxic fumes of cyanide and nitrogen oxides. Reacts violently with amines, alcohol, bases and warm water causing fire and explosion hazards. Avoid strong oxidizers, water, acids, bases, amines, etc., cause foam and splatter. Avoid heating. Hazardous polymerization may occur. Concentrated alkaline compound such as sodium hydroxide or tertiary amines may cause run-away polymerization. Slow, not hazardous polymerization may occur above 235F. (EPA, 1998)

Use powder, carbon dioxide, water in large amounts. In case of fire: keep drums, etc., cool by spraying with water. NO direct contact with water. Combat fire from a sheltered position.

Evacuate danger area! Consult an expert! Special emergency response required.

Evacuate danger area! Consult an expert! Personal protection: complete protective clothing including self-contained breathing apparatus. Collect leaking and spilled liquid in covered containers as far as possible. Treat remaining liquid with a mixture of ammonia (4-8%), detergent (2%), and water. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. If solid: sweep spilled substance into containers.

Spillage: Neutralize with special mixt (50% water, 45% alc, 5% concn ammonia water), collect leaking liq in sealable containers (extra personal protection: self-contained breathing apparatus).

NO open flames. NO contact with water. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Store between 20°C and 25°C. Separated from food and feedstuffs. See Chemical Dangers. Dry. Keep in a well-ventilated room.Store in a cool, dry, well-ventilated location. Separate from acids, alkalies, oxidizing materials, amines, and water. Immediately remove and properly dispose of any spilled material.

Occupational Exposure limit values

Biological limit values

Eye/face protection

Skin protection

Respiratory protection

Thermal hazards

2.5 ppm; NIOSH considers toluene-2,4-diisocyanate to be a potential occupational carcinogen.

The substance may polymerize under the influence of bases, tertiary amines and acyl chlorides. This generates fire or explosion hazard. On combustion, forms toxic gases and vapours including nitrogen oxides and isocyanates. Reacts readily with water, acids and alcohols. This generates pressure-rise explosion hazard.

Darkens on exposure to sunlight.

Combustible liquid.TOLUENE-2,4-DIISOCYANATE is explosive in the form of vapor when exposed to heat, flame or sparks. Undergoes potentially violent polymerization reaction with strong bases or acyl chlorides. Reacts with water to liberate carbon dioxide. Potential explosion if stored in polyethylene containers due to absorption of water through the plastic. Emits very toxic fumes of oxides of nitrogen when heated to decomposition [Lewis, 3rd ed., 1993, p. 1251].

no data available

Strong oxidizers, water, acids, bases, and amines (may cause foam and spatter); alcohols [Note: Reacts slowly with water to form carbon dioxide and polyureas].

When heated to decomposition, it emits highly toxic fumes of ... /nitrogen oxides/.

Acute toxicity

• Oral: LD50 - rat (male) - 5 110 mg/kg bw.
• Inhalation: LC50 - rat (male/female) - 66 ppm.
• Dermal: LD50 - rabbit (male/female) - > 9 400 mg/kg bw.

Skin corrosion/irritation

Serious eye damage/irritation

Respiratory or skin sensitization

Germ cell mutagenicity

Carcinogenicity

Reproductive toxicity

STOT-single exposure

STOT-repeated exposure

Aspiration hazard

• Toxicity to fish: LC50 - Oncorhynchus mykiss (previous name: Salmo gairdneri) - 133 mg/L - 96 h.
• Toxicity to daphnia and other aquatic invertebrates: EC50 - Daphnia magna - 12.5 mg/L - 48 h.
• Toxicity to algae: EC50 - Skeletonema costatum - 3 230 mg/L - 96 h.
• Toxicity to microorganisms: EC50 - activated sludge - > 100 mg/L - 3 h.

AEROBIC: Various process wastewaters from a petrochemical complex were subjected to biodegradability tests. Biodegradation tests on 2,4-toluene diisocyanate revealed 15% COD removal and 23% TOC removal of applied concentration(1). 2,4-Toluene diisocyanae present at 100 mg/L, reached 0% of its theoretical BOD in four weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test(2).

2,4-Toluene diisocyanate hydrolyzes rapidly in aqueous solution(1); therefore, bioconcentration will not be environmentally important(SRC).

2,4-Toluene diisocyanate hydrolyzes rapidly in aqueous solution(1); therefore, leaching and adsorption to sediment will not be environmentally important(SRC).

no data available

Product

Contaminated packaging

no data available

no data available

Information on revision

Abbreviations and acronyms

• CAS: Chemical Abstracts Service
• ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
• RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
• IMDG: International Maritime Dangerous Goods
• IATA: International Air Transportation Association
• TWA: Time Weighted Average
• STEL: Short term exposure limit
• LC50: Lethal Concentration 50%
• LD50: Lethal Dose 50%
• EC50: Effective Concentration 50%

References

• IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
• HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
• IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
• eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
• CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
• ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
• ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
• Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
• ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Other Information

Technical toluene diisocyanate is either 100% 2,4- or a mixture of 2,4- and 2,6-isomers. TDI is a common name. CAS number of the mixture is 26471-62-5.Depending on the degree of exposure, periodic medical examination is suggested.The symptoms of asthma often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation are therefore essential.Anyone who has shown symptoms of asthma due to this substance should avoid all further contact.The odour warning when the exposure limit value is exceeded is insufficient.