Hyaluronic Acid
Overview
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Hyaluronic acid, also known as HA. It is widely found in the human body and has the highest content in tissues such as the umbilical cord and joint synovial fluid. It is the main component of connective tissues such as human intercellular substance, vitreous body, and joint synovial fluid. This substance plays an important physiological function in the body of retaining water, maintaining extracellular space, regulating osmotic pressure, lubricating, and promoting cell repair. It has excellent water retention, lubricity, viscoelasticity, biodegradability and biocompatibility, and is used in medicine, food, beauty and skin care.ENTER
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HA PROPERTIES
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BIOLOGICAL PROPERTIES
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HA is a linear, non-branched polymer composed of disaccharides repeatedly and alternately connected: ß(1,4)-N-acetyl-D-glucosamine and ß(1,3)-D-glucuronic acid . Unlike other glycosaminoglycans (GAGs) that are high in ECM, such as heparin and chondroitin sulfate, HA is non-sulfated. The length of the HA chain ranges from ~0.200 to 10 MDA, and the most common size ranges from 2 to 5 MDa6,7,8.MORE
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HA dissolves in water to form a viscoelastic solution. As the concentration increases, the viscosity of the solution increases (10 mg/ml viscosity is 5000 times that of water. However, under the action of shear stress, the viscosity drops rapidly while maintaining elasticity. This feature This makes HA an ideal bio-lubricant. The actual structure of HA in ECM varies, but it is usually a random coil with extended structure and significant intrinsic rigidity. The hydrogen bonds between adjacent sugars constitute the biological properties of HA. The most important force. However, the in vitro physical properties of HA are also significantly affected by ionic strength.MORE
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Professional Perspect - Bloomage Biotech
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1934
HA was first separated from the vitreous body of a bull's eye and named after the vitreous body (= hyaluronic acid) and uronic acid.
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1930-40
HA is isolated from synovial fluid, skin, umbilical cord, tumor and male chicken crown.
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1951
The chemical structure of HA is determined
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1970s
Cartilage proteoglycan proved to have a special interaction with HA
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1993
Discovery and cloning of group A streptococcal hyaluronic acid synthase
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1999
First purification of active hyaluronic acid synthase
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Currently
HA is now mainly produced by bacterial fermentation
Functions of Hyaluronic Acid
Moisturizing skin
Anti-Aging
Nourish the skin
Promote wound healing
Lubricate joints, anti-bacterial and anti-inflammatory
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Pharmaceutical
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Cosmetics
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Food
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Viscoelasticity supplement therapy (medicine for improving knee arthritis, osteoarthritis and frozen shoulder). Viscoelastic filling (soft tissue filler). Viscoelastic barrier (anti-adhesion after operation). Viscoelastic protection (ophthalmic viscoelastic agent, contact lens protector). Drug carrier. -
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Used in skin care, hair, makeup, cleaning and other products. -
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Used in health foods such as capsules, tablets, granules, oral liquids, or ordinary foods such as beverages and candies.
Sodium Hyaluronate
Sodium Hyaluronate 95% from Shandong Focuschem BioTech Co., Ltd.: Food Grade Sodium Hyaluronate 95% has been widely used in the industry of nutraceuticals in US and EU. The oral sodium hyaluronate can support Hyaluronic Acid leveles in the body. Sodium Hyaluronate 95% can be digested and absorbed, making the skin moist, smooth, soft and elastic; delaying aging and preventing the occurrence of arthritis and brain atrophy.
- Top 5 Manufacturers
- Global Sales Amount
- Production Capacity
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Hyaluronic acid industry in China
China is the world's largest producer and marketer of hyaluronic acid, and the top 5 hyaluronic acid manufacturers in global sales are all Chinese companies. Among them, Huaxi Biotech accounts for about 36% of the global sales, and Focus Biotech accounts for 12%. -
Hyaluronic acid industry in China
From the perspective of raw materials, the global sales of hyaluronic acid raw materials in 2018 were 500 tons, of which food grade and cosmetics grade accounted for 46% and 50% respectively. In 2014-18, the compound growth rate of the sales of food grade, cosmetic grade, and pharmaceutical grade raw materials was 29.4%, 18.0%, and 22.1%, respectively, maintaining a relatively high growth rate. -
Hyaluronic acid industry in China
From the perspective of production capacity, Huaxi, the world's leading raw material sales company, has a production capacity of 420 tons, and a focus biological production capacity of 420 tons. Also, there are plans to expand production, so the production capacity is expected to be further increased in the future.
Market Outlook
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In 2018, China accounted for 86% of the global hyaluronic acid raw material production capacity, with a market size of approximately 3.07 billion yuan. In the next few years, the global hyaluronic acid raw material market will still maintain a compound growth rate of 18%. It is estimated that the global sales of hyaluronic acid raw materials will reach 1,150 tons in 2023.From the perspective of raw materials, the global sales of hyaluronic acid raw materials in 2018 were 500 tons, of which food grade and cosmetics grade accounted for 46% and 50% respectively. In 2014-18, the compound growth rate of the sales of food grade, cosmetic grade, and pharmaceutical grade raw materials was 29.4%, 18.0%, and 22.1%, respectively, maintaining a relatively high growth rate.ENTER
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Molecular Weight and Application
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Beauty and Skin Care
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Medical Beauty
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Food/Health Food
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- Macromolecular Hyaluronic Acid
- Medium-molecular Hyaluronic Acid
- Small Molecule Hyaluronic Acid
- Small Segments of Hyaluronic Acid
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Macromolecular hyaluronic acid - molecular weight 1,800,000 ~ 2,200,000
Very viscous, forming a breathable film on the skin to lock in moisture. Because of the high viscosity, it will make the skin feel firm, but evaporate after a long time. -
Medium-molecular hyaluronic acid - molecular weight 1,000,000 ~ 1,800,000
Moisturizing power is longer than that of large molecules, but it is still very large and will not be absorbed by the skin. -
Small molecule hyaluronic acid - molecular weight 400,000 ~ 1,000,000
Relatively strong permeability, can enhance blood circulation, promote metabolism, and perform deeper moisturizing. -
Hydrolyzed and digested small segments of hyaluronic acid
The molecular weight is several thousand to ten thousand or even smaller, and the size is small, and it can penetrate deeper into the skin. It also has the effect of quickly hydrating and repairing damage.
