Clinical Usage and Compatibility of Doxycycline Hydrochloride

Doxycycline hydrochloride, also known as doxycycline hydrochloride and deoxyoxytetracycline, is a tetracycline antibiotic with broad-spectrum antibacterial activity, but its antibacterial activity is 2-10 times higher than that of oxytetracycline. This is a commonly used medicine for breeding, and it is used frequently. It is often used for the treatment of avian mycoplasma and swine respiratory diseases, especially for the treatment of mixed infection of mycoplasma and bacteria. In summary, there are "many" bacteria, "four" diseases, and "one" worm.

Commonly used in these 4 cases

1. Bacterial diseases: mostly used in the respiratory tract, such as pleuropneumonia, swine pneumonia and other diseases, the effect of doxycycline hydrochloride + florfenicol + antipyretic drugs is good; actinomycetes: that is, various parts of the pig can grow Large pustules, except for Streptococcus pyogenes,

There is also a situation caused by actinomycetes. Generally, doxycycline hydrochloride is more effective;

2. Common "body" diseases:

(1) Mycoplasma is asthma, and doxycycline hydrochloride + florfenicol (or Zhiyuanjing) works well.

(2) Chlamydia, the first one is the sow abortion, the pearly afterbirth should be considered, and the treatment effect is better with doxycycline hydrochloride; the second kind of conjunctivitis, the eye drops with tetracycline-type drug eye drops have better effect.

(3) Treponema (swine dysentery, etc.) and Rickettsia are used less, so I won't say more.

3. Insects: It is blood protozoa, which is what we often call diseases such as erythropoiesis, and the effect of doxycycline hydrochloride administration is better.

4. Oxytetracycline is generally used in the prevention and treatment of sows, with fewer side effects and more moderate effects; doxycycline hydrochloride is mostly used in suckling piglets, which often appear after seven days, with yellow and white bands and leucorrhea. Ashes such as feces; fat pigs often have a fever rebound in dog days, repeatedly.

How to use doxycycline hydrochloride to double the effect?

1. The formula of florfenicol + doxycycline hydrochloride is very common, but do you know the ratio that can double the drug effect? So what is the ratio of doxycycline hydrochloride? Doxyl hydrochloride The correct ratio of cycline and florfenicol is 2:1. Everyone must dispense the medicine according to this ratio, otherwise the effect will not come out.

2. Specific algorithm: first calculate the dosage of doxycycline hydrochloride, and then divide the dosage of doxycycline hydrochloride by 2 to obtain the dosage of florfenicol.

3. The specific dosage: in the case of treatment, 1g of doxycycline hydrochloride water is mixed with 6-8 catties, and the dosage is calculated according to this amount, otherwise the effect will be very poor. Why do you need to increase the amount here? Here is a general knowledge for everyone, all tetracyclines should be used in the process of use.

Precautions:

1. The toxicity of this product is relatively small in this class of drugs, and generally does not cause bacterial flora imbalance, but it cannot be used in large doses for a long time;

2. Equine animals are sensitive to this product. Intravenous injection can cause poisoning or death. It is not suitable for intravenous injection.

3. Note that doxycycline hydrochloride injection is more painful, pay attention to stress;

Why is the treatment of erythropoiesis the first choice?

According to foreign data, because the biological characteristics of eperythrozoon are inconsistent with other conventional bacteria, it was initially classified as a member of the Microsporidia family (1974). Later classified as rickettsite. However, because it is not an intracellular obligate parasite, it is small, has no cell wall, is highly resistant, and is sensitive to tetracycline. Later, after sequencing, it was found that the genetic sequence of the pathogen was very similar to that of Rickettsia, but it was closer to the sequence of Mycoplasma. In recent years, the name of Mycoplasma suis has been widely used in western countries, because doxycycline hydrochloride has better curative effect on rickettsial and mycoplasma diseases, so tetracyclines may be more effective in the treatment of porcine eperythrozoon disease. In the process of treating eperythrozoonosis with tetracyclines, we found that doxycycline hydrochloride among the tetracyclines had the best effect.

Doxycycline Hydrochloride Combined with Carbaspirin Calcium in the Treatment of Respiratory Diseases in Livestock and Poultry

1. Doxycycline hydrochloride is a tetracycline broad-spectrum antibacterial and anti-mycoplasma drug. Its aqueous solution is acidic and is well absorbed by oral administration. It is easily soluble in water, and is easily affected by metal ions in water to form complexes, forming a red solution and reducing the efficacy of the drug. Therefore, in the selection of the drug, it is very important to select a product with formulation technology and ensure good stability.

2. In the clinical treatment of livestock and poultry, doxycycline hydrochloride is mainly used to treat respiratory tract infections caused by sensitive bacteria and mycoplasma. Among many pathogenic microorganisms, doxycycline is especially effective for trachea and bronchitis caused by Gram-negative bacteria and mycoplasma.

The main reasons for the better effect of doxycycline hydrochloride on trachea and bronchitis in livestock and poultry:

⑴ wide antibacterial spectrum, strong antibacterial effect. In addition to its good effect on gram-positive bacteria and gram-negative bacteria, it can inhibit respiratory mycoplasma, rickettsia and other pathogens that are resistant or insensitive to other drugs.

(2) Doxycycline hydrochloride is absorbed quickly after oral administration, it can exert its maximum effect in about 3 hours, and maintain its effect in the body for a long time.

(3) Doxycycline hydrochloride has certain antitussive, expectorant and asthmatic effects. These effects have been confirmed by animal experiments and are all characteristics that other antibiotics do not have.

These unique advantages of the above-mentioned doxycycline hydrochloride, as well as the plasma concentration of doxycycline hydrochloride to maintain an effective effect in livestock and poultry are longer than those of the currently commonly used clinical respiratory drugs, which further explains "why is doxycycline hydrochloride in the treatment of livestock and poultry? This is the reason for the better efficacy in trachea and bronchitis.”

3. Carbasalate calcium is an antipyretic and anti-inflammatory drug.

⑴It is a chelate of calcium acetylsalicylate (calcium salt of aspirin) and urea. Soluble in water, the aqueous solution is acidic. This product has significant antipyretic, analgesic, anti-inflammatory effects, rapid oral absorption, rapid onset of action, and high bioavailability. It can be widely combined with plasma proteins and is rapidly distributed to body tissues and organs such as trachea, bronchi and lungs.

(2) Carbaspirin calcium can inhibit the reaction of antigen-antibody conjugates in allergic reactions, and can improve the clinical symptoms such as redness, swelling, heat, pain and other symptoms in the process of inflammation, and reduce inflammatory exudation.

In the process of inhibiting the body's pathological response, carbasalate calcium can reduce inflammatory exudation by inhibiting the reaction of antigen-antibody conjugates in allergic reactions, and can inhibit the production of endotoxin and the increase in plasma protein caused by venous exudation. Inflammation and swelling, etc.

It can be seen from the physicochemical and pharmacological characteristics of the above two drugs that in the treatment of respiratory diseases of livestock and poultry, doxycycline and carbasalate calcium are formulated together and prescribed for the treatment of respiratory diseases caused by multiple causes of livestock and poultry. , better than doxycycline alone.

The prescription can enhance the antibacterial and anti-mycoplasma effects of doxycycline in rapidly controlling disease pathological deterioration and effective treatment, and the synergistic administration of the two drugs can significantly improve the therapeutic effect of doxycycline on respiratory diseases of livestock and poultry.