Depression is a mood disorder. Many women have mild mood disorders several years before menopause. Most of them appear periodically a few days before menstruation and naturally relieve after menstruation, which is called premenstrual syndrome. These patients may have an increased risk of perimenopausal depression. In addition, sleep interruptions caused by hot flashes and night sweats can significantly affect the mood of the next day, leading to irritability, depression, and inattention. Women face huge changes in their physiology, psychology, and social roles during the menopausal transition. Physiologically, during the transition from childbearing age to old age, ovarian function declines from vigorous, sex hormones are gradually lacking, and menopausal symptoms and a series of health problems such as osteoporosis, hyperlipidemia, cardiovascular disease, and Alzheimer's disease may occur; psychologically, they face the change of children's family formation and family structure, or lose confidence due to loss of fertility and body shape; at work, as they are approaching retirement age, they will return to an unemployed family life from a familiar and busy position for decades, and their social roles will change. If they lack the courage to adapt to new situations and explore new environments, they may experience obvious anxiety and depression; with age, the above-mentioned elderly diseases are also increasing, and the psychological pressure brought about by this cannot be ignored. The emotional problems caused by the huge physiological, psychological and social role changes during the menopausal transition period may, in turn, increase the burden on the family and society. The emotional problems caused by menopause have been increasingly valued by obstetrics and gynecology, psychiatry and other fields. Reasonable treatment will significantly improve the quality of life of women in this period, reduce the burden on society and family, and lay a solid foundation for a better life in old age.