Humans have been exposed to cotton dust since the early days of civilization when they used cotton and other plant fiber agricultural products to spin yarn and weave cloth. The emergence of a large number of textile industries following industrialization has attracted people's attention to the health effects of occupational exposure to cotton dust. The basic production processes of large cotton and linen textile factories, such as unpacking, blending, and combing, all generate a large amount of cotton dust, which is the main source of occupational exposure. People who are exposed to cotton dust for the first time or occasionally exposed to high concentrations of cotton dust may develop "mill fever", which is manifested by chills, muscle and joint pain, dry cough, fatigue, and fever several hours after exposure to cotton dust, similar to the early symptoms of influenza. It is now known that this is actually organic dust toxicity syndrome (ODTS). A small number of workers who are exposed to cotton dust experience decreased pulmonary ventilation function half an hour after the initial exposure, and the symptoms progressively worsen during the work week, which may be accompanied by wheezing, which is consistent with occupational asthma.