Amyloidosis is a group of clinical syndromes caused by various reasons. It is not an independent clinical disease, but a group of protein deposition diseases driven by tissue structure. The disease was first discovered by Wirchow in 1854. In the past 20 years, as amyloid substances were extracted from tissues of patients with various diseases, their corresponding chemical components were further analyzed and understood, and the diagnosis rate was significantly improved. In fact, amyloidosis is not uncommon in clinical practice. Its characteristics are that amyloid protein substances are deposited in blood vessel walls and tissues, causing various lesions, mainly involving organs and tissues such as the heart, kidneys, liver, spleen, gastrointestinal tract, joints, muscles and skin. Deposition can occur locally or systemically, and the course of the disease can be benign or malignant. The deposition of amyloid substances is often a partial manifestation of underlying diseases. The related disease states may be inflammation, autoimmune diseases, genetic diseases and tumors. The symptoms are determined by the original disease and the location and amount of amyloid deposition.