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Hydrocortisone

Hydrocortisone structure

CAS No:
50-23-7
Formula:
C21H30O5
Chemical Name:
Hydrocortisone
Synonyms:
Hydrocortisone Acetate Impurity?A;Prednisolone Impurity 1（Prednisolone EP Impurity A）;Prednisolone EP Impurity A;21-Trihydroxypregn-4-ene-3;compoundf(kendall);Cortanal;Cort-Dome;Cortenema

Description

crystalline white powder

ChEBI: A C21-steroid that is pregn-4-ene substituted by oxo groups at positions 3 and 20 and hydroxy groups at positions 11, 17 and 21. Cortisol is a corticosteroid hormone or glucocorticoid produced by zona fasciculata of the adrenal cortex, which is a part of the adrenal gland. It is usually referred to as the "stress hormone" as it is involved in response to stress and anxiety, controlled by corticotropin-releasing hormone (CRH). It increases blood pressure and blood sugar, and reduces immun responses

Hydrocortisone, 11β,17,21-trihydroxypregn-4-ene-3,20-dione, is the primary natural GCin humans. Despite the large number of synthetic GCs, hydrocortisone,its esters, and its salts remain a mainstay ofmodern adrenocortical steroid therapy and the standard forcomparison of all other GCs and MCs . It isused for all the indications mentioned previously.

Poison by

Recrystallise hydrocortisone from EtOH or isoPrOH. It is bitter tasting and has UV with max at 242 nm (log 4.20). Its solubility at 25o is: H2O (0.28%), EtOH (1.5%), MeOH (0.62%), Me2CO (0.93%), CHCl3 (0.16%), propylene glycol (1.3%) and Et2O (0.35%). It gives an intense green colour with conc H2SO4. [Wendler et al. J Am Chem Soc 72 5793 1950, Beilstein 8 IV 3422.]

Hydrocortisone Basic Attributes

Molecular Weight：

362.47

BRN：

1354819

EC Number：

200-020-1

TSCA：

TSCA listed

Color/Form：

White

HScode：

29372100

Characteristics

Density：

1.0812 (rough estimate)

Melting Point：

211-214 °C(lit.)

Boiling Point：

414.06°C (rough estimate)

Refractive Index：

1.6120 (estimate)

Water Solubility：

319.7mg/L(25 ºC)

Toxicity：

LD50 subcutaneous in mouse: > 500mg/kg

PH：

5.0- 7.0

Henrys Law Constant：

1.7×102mol/(m3Pa) at 25℃, HSDB (2015)

Critical Temperature & Pressure：

-20°C

Safety Information

wgk germany：

hazard class code：

safety instructions：

36/37

RTECS Number：

GM8925000

Storage features：

Store at RT

Hazard Statements：

62-63

Exposure Prevention：

Hydrocortisone is the principal glucocorticoid hor- mone produced by the adrenal cortex and is used topi- cally or systemically. It belongs to the allergenic A group. Marker of allergy is tixocortol pivalate.

Drug Information

Health Hazards：

Cortisol Increases (1) protein catabolism (excepting liver) gluconeogenesis; (2) carbohydrate anabolism (liver); (3) blood sugar; (4) glucose absorption; (5) brain excitation; (6) spread of infections; (7)urinary glucose and nitrogen; (8) stress tolerance; (9) lactation; (10) water diuresis.Regulates general adaptation syndrome, water balance, blood pressure, and hormone release.Decreases (1) fat anabolism; (2) growth rate; (3) inflammation; (4) eosinophils; (5) lymphocytes; (6) antigen sensitivity; (7) respiratory quotient; (8) ketosis; (9) wound healing; (10) skin pigmentation; (11)RBC hemolysis.

Hydrocortisone Use and Manufacturing

Principle glucocorticoid hormone produced by adrenal cortex. An anti-inflammatory hormone.

glucocorticoid, antiinflammatory

Cortisol, or Hydrocortisone, is a steroid hormone, more specifically a glucocorticoid, produced by the zona fasciculata of the adrenal gland. Cortisol is released in response to stress and a low level of blood glucocorticoids. Its primary functions are to increase blood sugar through gluconeogenesis; suppress the immune system; and aid in fat, protein and carbohydrate metabolism.

Material

Progesterone

Drug Function and Efficacy

This product is a glucocorticoid with anti-inflammatory, immunosuppressive, antitoxin and anti-shock effects. (1) Anti-inflammatory effect: It has an effect on inflammation caused by various causes except viruses. Glucocorticoids reduce and prevent tissue response to inflammation, thereby reducing the symptoms of inflammation. They can also inhibit the repair of tissues in the later stages of inflammation and reduce sequelae. (2) Immunosuppressive effect: It prevents or inhibits cell-mediated immune responses, delayed allergic reactions, and reduces the expansion of primary immune responses. (3) Anti-toxic and anti-shock effects: Glucocorticoids can improve the body's tolerance, reduce cell damage, and play a role in protecting the body. It also has the effects of dilating blood vessels, enhancing myocardial contractility, and improving microcirculation.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Hydrocortisone injection
Ingredients	Hydrocortisone.
Indication	1. Non-steroidal anti-inflammatory analgesics can enhance the effect of this product on gastrointestinal ulcers. 2. It can enhance the hepatotoxicity of acetaminophen. 3. When used in combination with amphotericin B or carbonic anhydrase inhibitors, it can aggravate hypokalemia. Long-term use with carbonic anhydrase inhibitors can easily lead to hypocalcemia and osteoporosis. 4. When used in combination with protein anabolic hormones, it can increase the incidence of edema and aggravate acne. 5. When used in combination with anticholinergics (such as atropine) for a long time, it can cause increased intraocular pressure. 6. Tricyclic antidepressants can aggravate the mental symptoms caused by this product. 7. When used in combination with hypoglycemic drugs such as insulin, the dosage of hypoglycemic drugs should be appropriately adjusted because this product can increase blood sugar in diabetic patients. 8. Thyroid hormones can increase the metabolic clearance rate of this product, so when used in combination with thyroid hormones or antithyroid drugs, the dosage of the latter should be appropriately adjusted. 9. When used in combination with contraceptives or estrogen preparations, the therapeutic effects and adverse reactions of this product can be enhanced. 10. When used in combination with cardiac glycosides, it can increase the toxicity of digitalis and the occurrence of arrhythmias. 11. When used in combination with potassium-excreting diuretics, it can cause severe hypokalemia and weaken the sodium-excreting and diuretic effects of diuretics due to water and sodium retention. 12. When used in combination with ephedrine, its metabolic clearance can be enhanced. 13. When used in combination with immunosuppressants, it can increase the risk of infection and may induce lymphoma or other lymphoproliferative diseases. 14. It can increase the metabolism and excretion of isoniazid in the liver, and reduce the blood concentration and efficacy of isoniazid. 15. It can promote the metabolism of mexiletine in the body and reduce its blood concentration. 16. When used in combination with salicylates, it can reduce the concentration of plasma salicylate. 17. When used in combination with growth hormone, it can inhibit the latter's growth-promoting effect.
Specifications	2ml: 10mg
Manufacturer	Wuhan Binhu Shuanghe Pharmaceutical Co., Ltd.

Hydrocortisone tablets
Ingredients	The main ingredient is: hydrocortisone, its chemical name: 11beta;,17alpha;,21-trihydroxypregnane-4-ene-3,20-dione.
Indication	1. Non-steroidal anti-inflammatory analgesics can enhance the effect of this product on gastrointestinal ulcers. 2. It can enhance the hepatotoxicity of acetaminophen. 3. When used in combination with amphotericin B or carbonic anhydrase inhibitors, it can aggravate hypokalemia. Long-term use with carbonic anhydrase inhibitors can easily lead to hypocalcemia and osteoporosis. 4. When used in combination with protein anabolic hormones, it can increase the incidence of edema and aggravate acne. 5. Long-term use with anticholinergics (such as atropine) can cause increased intraocular pressure. 6. Tricyclic antidepressants can aggravate the mental symptoms caused by this product. 7. When used in combination with hypoglycemic drugs such as insulin, the dosage of hypoglycemic drugs should be appropriately adjusted because this product can increase blood sugar in diabetic patients. 8. Thyroid hormones can increase the metabolic clearance rate of this product, so when used in combination with thyroid hormones or antithyroid drugs, the dosage of the latter should be appropriately adjusted. 9. When used in combination with contraceptives or estrogen preparations, the therapeutic effects and adverse reactions of this product can be enhanced. 10 When used in combination with cardiac glycosides, it can increase the toxicity of digitalis and the occurrence of arrhythmias. 11 When used in combination with potassium-excreting diuretics, it can cause severe hypokalemia and weaken the sodium-excreting and diuretic effects of diuretics due to water and sodium retention. 12 When used in combination with ephedrine, its metabolic clearance can be enhanced. 13 When used in combination with immunosuppressants, it can increase the risk of infection and may induce lymphoma or other lymphoproliferative diseases. 14 It can increase the metabolism and excretion of isoniazid in the liver, and reduce the blood concentration and efficacy of isoniazid. 15 It can promote the metabolism of mexiletine in the body and reduce the blood concentration. 16 When used in combination with salicylates, it can reduce the concentration of plasma salicylate. 17 When used in combination with growth hormone, it can inhibit the latter's growth-promoting effect.
Specifications	10mg
Manufacturer	Shanghai Quanyu Biotechnology Queshan Pharmaceutical Co., Ltd.

Hydrocortisone injection
Ingredients	Hydrocortisone.
Indication	1. Non-steroidal anti-inflammatory analgesics can enhance the effect of this product on gastrointestinal ulcers. 2. It can enhance the hepatotoxicity of acetaminophen. 3. When used in combination with amphotericin B or carbonic anhydrase inhibitors, it can aggravate hypokalemia. Long-term use with carbonic anhydrase inhibitors can easily lead to hypocalcemia and osteoporosis. 4. When used in combination with protein anabolic hormones, it can increase the incidence of edema and aggravate acne. 5. When used in combination with anticholinergics (such as atropine) for a long time, it can cause increased intraocular pressure. 6. Tricyclic antidepressants can aggravate the mental symptoms caused by this product. 7. When used in combination with hypoglycemic drugs such as insulin, the dosage of hypoglycemic drugs should be appropriately adjusted because this product can increase blood sugar in diabetic patients. 8. Thyroid hormones can increase the metabolic clearance rate of this product, so when used in combination with thyroid hormones or antithyroid drugs, the dosage of the latter should be appropriately adjusted. 9. When used in combination with contraceptives or estrogen preparations, the therapeutic effects and adverse reactions of this product can be enhanced. 10. When used in combination with cardiac glycosides, it can increase the toxicity of digitalis and the occurrence of arrhythmias. 11. When used in combination with potassium-excreting diuretics, it can cause severe hypokalemia and weaken the sodium-excreting and diuretic effects of diuretics due to water and sodium retention. 12. When used in combination with ephedrine, its metabolic clearance can be enhanced. 13. When used in combination with immunosuppressants, it can increase the risk of infection and may induce lymphoma or other lymphoproliferative diseases. 14. It can increase the metabolism and excretion of isoniazid in the liver, and reduce the blood concentration and efficacy of isoniazid. 15. It can promote the metabolism of mexiletine in the body and reduce its blood concentration. 16. When used in combination with salicylates, it can reduce the concentration of plasma salicylate. 17. When used in combination with growth hormone, it can inhibit the latter's growth-promoting effect.
Specifications	2ml:10mg

See More Related Drugs

Registered Holders

CURIA SPAIN SAU

United States
Active
EUROAPI FRANCE

France
Active
Tianjin Jinjin Pharmaceutical Co., Ltd.

China
Active

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Guide of Hydrocortisone

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Material
Drug Function and Efficacy
Related Drugs
Registered Holders
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Hydrocortisone

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