Clonorchiasis sinensis of bile duct, commonly known as liver fluke, was first found in the bile duct of a Chinese overseas in Kolkata, India in 1874 and confirmed in China in 1908. In 1975, eggs of Clonorchiasis sinensis were found in ancient corpses from the Western Han Dynasty and the Warring States period in Jiangling County, Hubei Province, proving that the disease has been prevalent in my country for at least 2,300 years. Clonorchiasis sinensis is almost universal in the world, mainly distributed in Asian countries such as China, Japan, North Korea, South Korea, and Vietnam. At present, 26 provinces, municipalities, autonomous regions, and special administrative regions in my country have this disease or are prevalent. Due to poor eating habits, the number of infected people in Guangdong Province is the highest, exceeding 5 million, accounting for half of the total number of infected people in the country. Adult parasites in the bile duct system cause chonorchiasis of bile duct. Mild cases may be asymptomatic, while severe cases cause cholecystitis, cholangitis, bile duct stones, bile duct tumors, malnutrition, and growth and development disorders.