Levamisole Hydrochloride Pills

This product is the levorotatory form of tetramisole, which can selectively inhibit succinate dehydrogenase in the muscles of the worm, so that fumaric acid cannot be reduced to succinic acid, thereby affecting the anaerobic metabolism of the muscles of the worm and reducing energy production. When the worm comes into contact with it, it can depolarize the nerves and muscles, and the muscles will continue to contract and cause paralysis; the drug's mimetic cholinergic effect is conducive to the excretion of the worm. Its activity is about 1 to 2 times that of tetramisole (racemic form), but its toxic side effects are lower. In addition, the drug may have an inhibitory effect on the microtubule structure of the worm. Levamisole also has immunomodulatory and immune excitation functions.

The content of levamisole hydrochloride (C11H12N2S·HCl) in this product should be 90.0% to 110.0% of the labeled amount.

This product is small white pills.

Used to treat ascariasis, hookworms, and pinworms. This product has a high single-dose efficacy and can be used for group treatment. This product is effective against adult worms and microfilariae of Bancroftian filariasis, Malayan filariasis, and Onchocerca volvulus, but the long-term efficacy is poor.

Oral. 1. For deworming: 1.5-2.5 mg/kg for adults, take it all at once on an empty stomach or before bedtime, and 2-3 mg/kg for children. 2. For deworming: 1.5-2.5 mg/kg, once a night, for 3 consecutive days. 3. For the treatment of filariasis: 4-6 mg/kg, divided into 2-3 doses, for 3 consecutive days.

Generally mild. Symptoms include nausea, vomiting, abdominal pain, etc. A few may experience taste disorders, fatigue, dizziness, headache, joint pain, confusion, insomnia, fever, flu-like symptoms, low blood pressure, vasculitis, rash, photosensitivity dermatitis, etc. Occasionally, proteinuria is seen. In some cases, granulocytopenia and thrombocytopenia may be seen. In some cases, agranulocytosis (often reversible) may even occur. It often occurs in patients with rheumatism or tumors. It can also cause immediate and Arthus allergic reactions, which may be atopic reactions caused by stimulating T cells. Individual cases may experience ataxia, paresthesia or blurred vision.

It is contraindicated for patients with impaired liver and kidney function, active hepatitis, early pregnancy, or pre-existing schistosomiasis.

Precautions for children: Not yet clear. Precautions for pregnancy and lactation: Not allowed in early pregnancy. Precautions for the elderly: Not yet clear.

(1) It can be used in combination with pyrantel to treat severe hookworm infections and improve the effectiveness of expelling American hookworms. (2) It can be used in combination with thiabendazole to treat mixed intestinal nematode infections. (3) It can be used sequentially with diethylcarbamazine citrate to treat filarial infections. (4) It should not be used in combination with tetrachloroethylene to avoid increasing its toxicity.

Keep sealed.

2 mg

24 months

Liaoning Haiyi Pharmaceutical Co., Ltd.

• Founded in:

  2014-05-15

• Address:

  No. 6-5 Central Avenue, Xinmin City

• Tax NO.:

  912101810996314936

• Registered Funds:

  79.52 million yuan

• Email:

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